Process Analytical Technology PAT | R&D, Scale-up & Manufacturing

Process Analytical Technology (PAT)

PAT is Changing Chemical Process Development, Scale-up, and Manufacturing

Process Analytical Technology (PAT)

Process Analytical Technology in R&D
Process Analytical Technology (PAT)
In Situ Reaction Analysis Tools
Inline Particle Characterization
Heat Flow Calorimetry in PAT

Applikationer

Measure Crystal Size Distribution
Förbättra kristallisationen med inlinemätning av partikelstorlek, form och antal

Sondbaserade teknologier som används medan processen pågår tillämpas för att spåra storleks- och formförändringar för partiklar vid full koncentration utan behov av utspädning eller extraktion. Genom att spåra hastighet och förändringsgrad för partiklar och kristaller i realtid, kan de korrekta processparametrarna för kristallationsprestandan optimeras.

kristallisation och kristallisering
Optimera kristallstorlek, avkastning och renhetsgrad

En av de största utmaningarna inom processutveckling kan vara optimering och uppskalning av Kristallisering och utfällning.

Chemical Process Development & Scale-Up
Design Robust and Sustainable Chemical Processes For Faster Transfer To Pilot Plant and Production

Design Robust and Sustainable Chemical Processes For Faster Transfer To Pilot Plant and Production

Impurity Profiling of Chemical Reactions
Continuous Automated Reaction Sampling Improves Productivity and Understanding for Chemists

Knowledge of impurity kinetics and mechanism of formation is important in determining reaction end-point in chemical and process development studies. Accurate, reproducible, and representative reactions samples are necessary for these studies.

Chemical Reaction Kinetics Studies
Study Chemical Reaction Rates and Measure Kinetics Inline

In situ chemical reaction kinetics studies provide an improved understanding of reaction mechanism and pathway by providing concentration dependences of reacting components in real-time. Continuous data over the course of a reaction allows for the calculation of rate laws with fewer experiments due to the comprehensive nature of the data.  Reaction Progression Kinetics Analysis (RPKA) uses in situ data under synthetically relevant concentrations and captures information throughout the whole experiment ensuring that the complete reaction behavior can be accurately described.

Flow Chemistry
Improve Safety, Reduce Cycle Time, Increase Quality and Yield

Continuous flow chemistry opens options with exothermic synthetic steps that are not possible in batch reactors, and new developments in flow reactor design provide alternatives for reactions that are mixing limited in batch reactors. This can often result in better product quality and higher yield.  When coupled with Process Analytical Technology (PAT), flow chemistry allows for rapid analysis, optimization, and scale-up of a chemical reaction.

Grignard Reaction Mechanisms
Understand and Control Exothermic Events

Grignard reactions are one of the most important reaction classes in organic chemistry. Grignard reactions are useful for forming carbon-carbon bonds. Grignard reactions form alcohols from ketones and aldehydes, as well as react with other chemicals to form a myriad of useful compounds. Grignard reactions are performed using a Grignard reagent, which is typically a alkyl-, aryl- or vinyl- organomagnesium halide compound. To ensure optimization and safety of Grignard reactions in research, development and production, in situ monitoring and understanding reaction heat flow is important.

Formulations and Product Development
Develop Solid and Liquid Formulations With Desired Disintegration and Dissolution Profiles

Develop Solid and Liquid Formulations With Desired Disintegration and Dissolution Profiles

Measure Crystal Size Distribution

Sondbaserade teknologier som används medan processen pågår tillämpas för att spåra storleks- och formförändringar för partiklar vid full koncentration utan behov av utspädning eller extraktion. Genom att spåra hastighet och förändringsgrad för partiklar och kristaller i realtid, kan de korrekta processparametrarna för kristallationsprestandan optimeras.

kristallisation och kristallisering

En av de största utmaningarna inom processutveckling kan vara optimering och uppskalning av Kristallisering och utfällning.

Chemical Process Development & Scale-Up

Design Robust and Sustainable Chemical Processes For Faster Transfer To Pilot Plant and Production

Impurity Profiling of Chemical Reactions

Knowledge of impurity kinetics and mechanism of formation is important in determining reaction end-point in chemical and process development studies. Accurate, reproducible, and representative reactions samples are necessary for these studies.

Chemical Reaction Kinetics Studies

In situ chemical reaction kinetics studies provide an improved understanding of reaction mechanism and pathway by providing concentration dependences of reacting components in real-time. Continuous data over the course of a reaction allows for the calculation of rate laws with fewer experiments due to the comprehensive nature of the data.  Reaction Progression Kinetics Analysis (RPKA) uses in situ data under synthetically relevant concentrations and captures information throughout the whole experiment ensuring that the complete reaction behavior can be accurately described.

Flow Chemistry

Continuous flow chemistry opens options with exothermic synthetic steps that are not possible in batch reactors, and new developments in flow reactor design provide alternatives for reactions that are mixing limited in batch reactors. This can often result in better product quality and higher yield.  When coupled with Process Analytical Technology (PAT), flow chemistry allows for rapid analysis, optimization, and scale-up of a chemical reaction.

Grignard Reaction Mechanisms

Grignard reactions are one of the most important reaction classes in organic chemistry. Grignard reactions are useful for forming carbon-carbon bonds. Grignard reactions form alcohols from ketones and aldehydes, as well as react with other chemicals to form a myriad of useful compounds. Grignard reactions are performed using a Grignard reagent, which is typically a alkyl-, aryl- or vinyl- organomagnesium halide compound. To ensure optimization and safety of Grignard reactions in research, development and production, in situ monitoring and understanding reaction heat flow is important.

Formulations and Product Development

Develop Solid and Liquid Formulations With Desired Disintegration and Dissolution Profiles

Trycksaker

White Papers

A Guide to Crystallization and Precipitation
The quality of a crystallization process greatly influences the quality of the final product. Our new white paper introduces you to the fundamentals o...
How to Optimize a Crystallization Step Using Simple Image Analysis
By quickly identifying unnecessary hold times and determining how cooling rate influences crystal growth and nucleation, the cycle time for an interme...
Process FTIR för säker användning av natriumborohydridreduktion
John O'Reilly från Roche Ireland pratar om hållbar processanalysteknik (PAT) med process FTIR för säker användning av natriumborohydridreduktion.
In situ-övervakning av kemiska reaktioner
”Hur gör man mer med mindre?” är ett konstant ämne på kemikaliska utvecklingslaboratorier då forskare behöver få fram kemiprodukter snabbt och kostnad...
Snabb analys av kontinuerliga experiment med reaktionsoptimering
Detta white paper – Snabb analys av experiment med reaktionsoptimering – behandlar hur man kan optimera kemiska reaktioner.
Effektiv design av experimentstudier
I detta dokument beskrivs hur Design of Experiments (DoE) fungerar och hur det används för att identifiera relationerna mellan parametrar, fastställer...
Risker med stigande temperaturer
Inom kemisk processuppskalning är det kritiskt för processäkerheten att förstå temperaturändring och den associerade värmen som ackumuleras av reaktio...
PAT for Emulsions
Use PAT for emulsions and suspension characterization without the need for sampling or sample prep.
Monitor Tablet & Granule Disintegration
The role of in-process particle measurement to complement traditional API dissolution studies is presented. The use of particle size and count measure...
Partikelstorleksanalys för processoptimering
Detta white paper presenterar några av de vanligaste metoderna för partikelstorleksanalys och hur de kan användas för att effektivt leverera partikelp...

On-Demand Webinars

Breaking Barriers to Manufacturing Innovation
Frederic Buono discusses how Boehringer Ingelheim uses continuous flow technology to break barriers in manufacturing innovation.
Crystallization Image Analysis
Presented by Prof. Zoltan Nagy of Purdue University, this talk provides an overview of recent advances of applications for in situ imaging and image a...
Flow and Batch Chemistry Monitoring
Charles Goss presents examples illustrating how GlaxoSmithKline (GSK) monitors flow and batch chemistry unit operations in both laboratory and pilot p...
Liquid-Liquid Phase Separation
This presentation describes a strategy employed to design and develop robust, scalable crystallization processes that avoids Liquid-Liquid Phase Separ...
New Tools For Continuous Flow Chemistry
Andrea Adamo of MIT and Zaiput Flow Technologies discusses new tools for continuous flow chemistry advancement.
Agglomeration & Crystallization Using Particle Measurement
This presentation details how using data from in situ particle vision and measurement tools can be used to determine particle size and shape trends re...
Lubrizol processutveckling och utökning av verksamheten
Detta webinar fokuserar på att förbättra processutveckling och uppskalning genom att använda kalometri och in situ-processanalys. För att kunna ge bäs...
Mercks kemiska processutveckling
Shane Grosser pratar om hur Mercks laboratorium för intensifiering av processutveckling tar fram nya verktyg och metoder för att höja hastigheten och...

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