Dynochem
Fit for Purpose Modeling and Simulation
Dynochem® is the world’s leading unit operation modeling and scale-up prediction software for scientists and engineers working in the pharmaceutical and fine chemical industries. With Dynochem, scientists and engineers can simulate the process performance of every reaction, workup, and isolation operation before scale-up from lab to pilot plant and manufacturing. This approach gives a higher success rate for scale-up and smooth digital technology transfer between sites and partners.
Developed with input from industrial partners and users, Dynochem tools are matched against common project goals, workflows, equipment, and data availability.
dynochem chemical reaction modeling software
Right-First-Time Scale-up
Dynochem enables scientists and engineers to predict the process performance on scale-up from lab to pilot plant and manufacturing. Users experience a higher success rate for scale-up and smooth, digital technology transfer between sites.
Used extensively in drug substance process development and into primary manufacturing, Dynochem provides a chemical process simulation and modeling platform for process optimization, troubleshooting, and calculating right-first-time scaleup parameters
Extensive Model Library
Dynochem Resources is a comprehensive library of API reaction, workup, and isolation models, which delivers powerful simulations to all levels of users in every project. An extensive library of user knowledge and know-how makes it possible to learn from the community, building further expertise in modeling.
Dynochem template models include:
- Mixing and heat transfer in stirred tank reactors
- Reactions in batch and semi-batch reactors
- Binary and ternary...
Optimization with Fewer Experiments
Combining data with equipment characteristics enables the calculation of optimal process conditions and equipment utilization in batch and flow operations. Using these methods in tandem makes it possible to deliver better processes using fewer experiments.
Expert Support
A global team of expert scientists and engineers delivers project support and training to users around the world to ensure their success. A regular series of training and seminar events provides the opportunity to network with users across industries and learn best practices from peers and Dynochem experts.
Access to Full Knowledge Base
With Dynochem, you get access to our full Knowledge Base with a wealth of content including:
- Template models
- Training material
- Guidance documents
- Links to hundreds of peer-reviewed journal articles using Scale-up Suite tools for modeling success
Free training sessions are also available so you get the most out of your software.
Dynochem FAQs
What does Dynochem do?
Dynochem software offers dynamic chemical process simulation and optimization by combining data with equipment characteristics and powerful predictive models. The calculation of optimal process conditions and equipment utilization makes it possible to deliver better processes using fewer overall experiments.
An extensive library of template models is available to all users. The application of models is supported by free training, expert guidance, and project support. Some of the most commonly used Dynochem applications include:
- Solvent temperature-dependent properties and solvent interaction predictions
- Mixing and Heat Transfer assessment and characterization tools for STRs and PFRs
- Simulation of heating or cooling a reactor to quickly calculate the time required to bring a reactor to the recipe temperature for a reaction, crystallization, or other operation
- Reaction models for homogeneous and heterogeneous reactions in batch and flow chemistry operations
- Crystallization models to predict particle size distribution (PSD)
- Dynamic models of batch solvent swap operations in continuous and put-and-take modes to predict the amount of fresh solvent required on scale-up and the operation time
- Tools to characterize key filtration process parameters and predict scale-up performance from lab to plant filtration equipment and between filtration and centrifugation operations
How can this help in process development?
With Dynochem, teams of chemists and chemical engineers in process development and primary manufacturing can scale up, troubleshoot, and optimize reaction, workup, and isolation stages with confidence. Common projects where Dynochem is used include:
- Ensure adequate mixing and mixing equivalence on scale-up
- Predict thermal process safety and effect of addition rates and heat transfer on Time to Maximum Rate (TMR) and Maximum Temperature of Synthesis Reaction (MTSR)
- Robust crystallization design from standard solubility experiments to optimize seeding strategy, cooling profile, and anti-solvent addition rate to promote crystal growth
- De-bottleneck and optimize filtration and centrifugation equipment selection and operation
- Design continuous manufacturing equipment and operating conditions to fit process chemistry needs
What is the difference between Dynochem and iC Safety?
The key difference is that Dynochem predictions are based on a kinetic model, which allows great flexibility in determining the behavior of your process in different equipment setups, and thus allows the optimization of a safe process in silico. In comparison, iC Safety is based on determining standard metrics like MAT and DTad from RC1 data and using this to determine the Stoessel safety class. It won't directly allow you to predict, for example, what conditions would allow you to run the process safely when transferring to a large-scale vessel. The two approaches are complementary, however, and both are very robust!
What template models does Dynochem include?
Dynochem template models include:
- Mixing and Heat Transfer in stirred tank reactors
- Reactions in batch and semi-batch reactors
- Binary and Ternary phase equilibria
- Batch distillation and solvent swap
- Crystallization
- Filtration & centrifugation
- Drying
Common operations in continuous processing such as:
- Mixing and Heat Transfer in PFRs
- Reactions in CSTRs and PFRs
- Crystallization in CSTRs
- Counter-current extraction
- Wiped-film evaporator