Chemical Reaction Kinetics Studies - METTLER TOLEDO

Chemical Reaction Kinetics Studies

Study Chemical Reaction Rates and Measure Kinetics Inline

Kinetics, Mechanism and Pathway
Kinetics in C-H Activations
ReactIR with iC Kinetics software

Applikationer

Applications Related to Chemical Reaction Kinetics Studies

Organisk syntes
Screening och optimering av katalys, hydrering, polymersyntes och andra reaktiva kemiska synteser

Kemister som arbetar inom syntetisk organisk kemi upptäcker och utvecklar innovativa kemiska reaktioner och processer.

kristallisation och kristallisering
Optimera kristallstorlek, avkastning och renhetsgrad

En av de största utmaningarna inom processutveckling kan vara optimering och uppskalning av Kristallisering och utfällning.

Impurity Profiling of Chemical Reactions
Continuous Automated Reaction Sampling Improves Productivity and Understanding for Chemists

Knowledge of impurity kinetics and mechanism of formation is important in determining reaction end-point in chemical and process development studies. Accurate, reproducible, and representative reactions samples are necessary for these studies.

Mass Transfer and Reaction Rate
Mixing in a Chemical Reactor and the Effect on Reaction Kinetics and Scale-up

Mixing is the reduction or elimination of inhomogeneity of phases that are either miscible or immiscible. Process scale-up and optimization require that the impact of mixing on the reaction rate be quantified. Automated, controlled experiments can be run in parallel in a laboratory reactor system to establish a mass transfer correlation, and provide a means to quickly adjust the gas/ liquid interface area and reactor volume. This achieves the desired conditions required for the scale-up or scale-down of a process.

Heat Transfer and Process Scale-up
How Heat Transport in Agitated Vessels Affects Process Scale-up

Scaling-up a chemical process from lab to manufacturing gives useful results only with accurate heat transfer coefficients. Measuring the jacket and reactor temperature (during the release of a well-defined amount of heat) allows researchers to accurately compute the thermal resistance which is used to model the heat transfer and make critical predictions for reactors at larger scale. Reaction calorimetry is essential to determine parameters that impact the heat transfer and the heat transfer coefficients to develop models to maximize the bandwidth of a manufacturing plant. 

Chemical Process Safety
Determine the Safety of Chemical Processes Prior to Scale-up

How can I be sure that my chemical process is safe? It is critical to understand the risks inherent in moving a chemical process to a larger scale before manufacturing begins. The use of reaction calorimetry is an essential part of process development studies, providing detailed information about the rate of heat production. This allows researchers to optimize the temperature and dosing profiles to maximize process safety at all times, and reduce to a minimum the risks involved.

Chemical Process Development & Scale-Up
Design Robust and Sustainable Chemical Processes For Faster Transfer To Pilot Plant and Production

Design Robust and Sustainable Chemical Processes For Faster Transfer To Pilot Plant and Production

Flow Chemistry
Improve Safety, Reduce Cycle Time, Increase Quality and Yield

Continuous flow chemistry opens options with exothermic synthetic steps that are not possible in batch reactors, and new developments in flow reactor design provide alternatives for reactions that are mixing limited in batch reactors. This can often result in better product quality and higher yield.  When coupled with Process Analytical Technology (PAT), flow chemistry allows for rapid analysis, optimization, and scale-up of a chemical reaction.

Organisk syntes

Kemister som arbetar inom syntetisk organisk kemi upptäcker och utvecklar innovativa kemiska reaktioner och processer.

kristallisation och kristallisering

En av de största utmaningarna inom processutveckling kan vara optimering och uppskalning av Kristallisering och utfällning.

Impurity Profiling of Chemical Reactions

Knowledge of impurity kinetics and mechanism of formation is important in determining reaction end-point in chemical and process development studies. Accurate, reproducible, and representative reactions samples are necessary for these studies.

Mass Transfer and Reaction Rate

Mixing is the reduction or elimination of inhomogeneity of phases that are either miscible or immiscible. Process scale-up and optimization require that the impact of mixing on the reaction rate be quantified. Automated, controlled experiments can be run in parallel in a laboratory reactor system to establish a mass transfer correlation, and provide a means to quickly adjust the gas/ liquid interface area and reactor volume. This achieves the desired conditions required for the scale-up or scale-down of a process.

Heat Transfer and Process Scale-up

Scaling-up a chemical process from lab to manufacturing gives useful results only with accurate heat transfer coefficients. Measuring the jacket and reactor temperature (during the release of a well-defined amount of heat) allows researchers to accurately compute the thermal resistance which is used to model the heat transfer and make critical predictions for reactors at larger scale. Reaction calorimetry is essential to determine parameters that impact the heat transfer and the heat transfer coefficients to develop models to maximize the bandwidth of a manufacturing plant. 

Chemical Process Safety

How can I be sure that my chemical process is safe? It is critical to understand the risks inherent in moving a chemical process to a larger scale before manufacturing begins. The use of reaction calorimetry is an essential part of process development studies, providing detailed information about the rate of heat production. This allows researchers to optimize the temperature and dosing profiles to maximize process safety at all times, and reduce to a minimum the risks involved.

Chemical Process Development & Scale-Up

Design Robust and Sustainable Chemical Processes For Faster Transfer To Pilot Plant and Production

Flow Chemistry

Continuous flow chemistry opens options with exothermic synthetic steps that are not possible in batch reactors, and new developments in flow reactor design provide alternatives for reactions that are mixing limited in batch reactors. This can often result in better product quality and higher yield.  When coupled with Process Analytical Technology (PAT), flow chemistry allows for rapid analysis, optimization, and scale-up of a chemical reaction.

Trycksaker

Publications Related to Chemical Reaction Kinetics Studies

White Papers

Grignard-reaktion uppskalning – 4 steg för att kontrollera utveckling
Exotermiska reaktioner har inneboende risker – särskilt vid uppskalning. Publicerade studier från ledande kemi- och läkemedelsföretag visar att genom...
In situ-övervakning av kemiska reaktioner
”Hur gör man mer med mindre?” är ett konstant ämne på kemikaliska utvecklingslaboratorier då forskare behöver få fram kemiprodukter snabbt och kostnad...
Metal Catalyzed Transformations Using In Situ Spectroscopy
This white paper reviews recent advances in organic chemistry using chemical reaction monitoring.
Kemisk syntes bortom den rundbottnade kolven
Lär dig hur du kan förbättra din organiska syntes!Detta White Paper informationsdokumentet tar upp nya metoder för organisk syntes, bland annat hur ma...
Real-Time Reaction Monitoring
Real time, in situ mid-FTIR reaction monitoring leads to a greater understanding of catalyst activity and robustness. Researchers at the University of...
Process FTIR för säker användning av natriumborohydridreduktion
John O'Reilly från Roche Ireland pratar om hållbar processanalysteknik (PAT) med process FTIR för säker användning av natriumborohydridreduktion.

On-Demand Webinars

Reaction Progress Kinetic Analysis
Professor Donna Blackmond discusses how Reaction Progress Kinetic Analysis (RPKA) methodology simplifies kinetic studies of organic reactions.
Reaction Progress Kinetic Analysis: A Powerful Methodology for Streamlining the Study of Complex Organic Reactions
Professor Donna Blackmond continues the discussion on how Reaction Progress Kinetic Analysis (RPKA) methodology simplifies the kinetic studies of orga...
Reaction Kinetics Progress Analysis Ryan Baxter
This webinar explores a graphical analysis approach to rationalize unusual kinetics in C-H activations. The Reaction Progress Kinetic Analysis (RPKA)...
Development of Continuous Processes
David Ford of Nalas investigated an Oxidative Nitration reaction with a fast and highly exothermic oxidation step using reaction calorimetry and Proce...
Impact of FTIR Studies on the Understanding of Asymmetric Rhodium Catalyzed Carbenoid Reactions
The use of Fourier Transform Infrared (FTIR) spectroscopy to understand the effect of catalyst, substrate, and carbenoid precursor on the rate and eff...
Polymerization Process Monitoring
This presentation discusses polymerization process monitoring and how the value of real-time in situ Fourier Transform Infrared (FTIR) spectroscopy co...
Accelerated Process Development
Process development focused on continuous processes can utilize many of the same tools used in traditional batch processes. Nalas Engineering develops...

Citations

ReactIR Citation List
Continuous measurements from infrared spectroscopy are widely used for obtaining reaction profiles, which are used to calculate reaction rates. This...

Relaterade produkter

Products for Chemical Reaction Kinetics Studies

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