Rationalizing Unusual Kinetics in C-H Activations

Reaction Kinetics

This webinar explores a graphical analysis approach to rationalize unusual kinetics in C-H activations. The Reaction Progress Kinetic Analysis (RPKA) methodology is discussed.

Typically, traditional methods of initial rate measurements require many experiments run under artificially high concentrations of reaction components, potentially diminishing the practicality and utility of kinetic analysis.

In contrast, Reaction Progress Kinetic Analysis (RPKA) extracts a maximum amount of kinetic information from a minimal number of experiments run under synthetically relevant conditions. Simple graphical manipulations of reaction progressions probe catalyst stability and reveal kinetic driving forces of reaction components by visual inspection. The RPKA methodology is used in the context of palladium-catalyzed C-H olefinations of arylacetic acids to explain anomalous rate behavior including the inhibitory action of several off-cycle catalytic species.

This webinar is for chemists, engineers and researchers interested in reaction kinetics, as well as anyone who finds it difficult or time consuming to determine the kinetics and reaction behavior of chemistry.

Guest Presenter: Professor Ryan Baxter

Dr. Baxter received a B.Sc. with Honors from the University of Wisconsin and a Ph.D. focusing on organometallic cross-coupling reactions from the University of Michigan.  Dr. Baxter completed an NIH post-doctoral fellowship working with Professors Donna Blackmond and Phil Baran at The Scripps Research Institute using kinetic analysis to study and develop novel radical reactions. Dr. Baxter is currently an Assistant Professor of Chemistry and Chemical Biology at the University of California - Merced. 

Rationalizing Unusual Kinetics in C-H Activations
Professor Ryan Baxter