Raman Spectrometers for In-Situ Reaction Analysis

Flexible and Versatile Raman Spectrometers

in situ raman spectrometer workstation

In-Situ Raman Probes

Probe- and flow-based sampling technologies enable scientists to study liquid and solid phase chemistry in batch or continuous setups. Fit-for-purpose materials enable a wide range of temperatures, pressures, and chemistries.

OneClick Raman spectrometer Analytics

One Click Analytics™

Designed specifically for time-resolved reaction analysis, iC Raman™ software combines a peak picking algorithm with functional group intelligence to drastically reduce analysis time. Podrobnosti

Raman spectrometer instrument support

Reaction Analysis Experts

As a company, METTLER TOLEDO has over 30 years of dedicated reaction analysis experience. This is our focus and our passion. We built this expertise into fit-for-purpose Raman spectrometers.

What is a Raman probe?

raman probe definition

A Raman probe is a device used in Raman spectroscopy, a technique for analyzing the chemical composition of a sample by measuring the scattered light from its molecules. The probe typically consists of a laser, a lens system to focus the laser onto the sample, and a detector to measure the scattered light. The Raman effect, also known as Raman scattering, which is the basis of the technique, is the inelastic scattering of light by a sample, resulting in a shift in the wavelength of the scattered light. This shift is characteristic of the chemical bonds in the sample and can be used to identify the molecules present.

How do you use a Raman probe?

how to use a raman probe

  1. Plug-in your ReactRaman
  2. Connect your Raman probe or sampling technology
  3. Place the Raman probe into your reaction

Corrosion-resistant materials are used in our in-situ Raman probes to increase the lifespan and reliability of the probe. These materials are able to withstand exposure to harsh chemical environments and protect the probe from damage, reducing the need for frequent replacement or maintenance. Additionally, using corrosion-resistant materials can also improve the accuracy and precision of the measurements taken by the probe.

What is Raman spectroscopy?

what is raman spectroscopy

what is raman spectroscopy
what is raman spectroscopy

Is Raman or FTIR better for my application?

Raman and FTIR spectrometers offer molecular information about the structure and composition of chemical and biological samples. Because of the fundamental principles that govern each technology, both can yield complementary information. However, frequently one technology is a better choice, depending on the nature of the application.

Learn more about Raman vs. FTIR spectroscopy.

Raman Spectrometers in Journal Publications

Below is a selection of publications featuring Raman spectrometers

  • Yang, L., Zhang, Y., Liu, P., Wang, C., Qu, Y., Cheng, J., & Yang, C. (2022). Kinetics and population balance modeling of antisolvent crystallization of polymorphic indomethacin. Chemical Engineering Journal, 428, 132591. https://doi.org/10.1016/j.cej.2021.132591
  • Marzijarani, N. S., Fine, A., Dalby, S. M., Gangam, R., Poudyal, S., Behre, T., Ekkati, A. R., Armstrong, B. A., Shultz, C. S., Dance, Z. E. X., & Stone, K. H. (2021). Manufacturing Process Development for Belzutifan, Part 4: Nitrogen Flow Criticality for Transfer Hydrogenation Control. Organic Process Research & Development, 26(3), 533–542. https://doi.org/10.1021/acs.oprd.1c00231
  • Wu, Y., Zhang, H., Wang, N., Chen, T., & Liu, Y. (2021). A Study on the Crystal Transformation Relationships of Valacyclovir Hydrochloride Polymorphs: Sesquihydrate, Form I, and Form II. Crystal Research and Technology, 2100084. https://doi.org/10.1002/crat.202100084
  • Fang, C., Gong, J., Wu, S., Wang, J., & Gao, Z. (2020). Ultrasound-assisted intensified crystallization of L-glutamic acid: Crystal nucleation and polymorph transformation. Ultrasonics Sonochemistry, 68, 105227. https://doi.org/10.1016/j.ultsonch.2020.105227
  • Østergaard, I., De Diego, H. L., Qu, H., & Nagy, Z. K. (2020). Risk-Based Operation of a Continuous Mixed-Suspension-Mixed-Product-Removal Antisolvent Crystallization Process for Polymorphic Control. Organic Process Research & Development, 24(12), 2840–2852. https://doi.org/10.1021/acs.oprd.0c00368
  • Wang, Y. X., Yu, J., Wang, Y., Chen, Z., Dong, L., Cai, R., Hong, M., Long, X., & Yang, S. (2020). In situ templating synthesis of mesoporous Ni–Fe electrocatalyst for oxygen evolution reaction. RSC Advances, 10(39), 23321–23330. https://doi.org/10.1039/d0ra03111a
  • Zhang, S., Zhou, L., Yang, W., Xie, C., Yang, X., Hou, B., Hao, H., Zhou, L., Bao, Y., & Yin, Q. (2020). An Investigation into the Morphology Evolution of Ethyl Vanillin with the Presence of a Polymer Additive. Crystal Growth & Design, 20(3), 1609–1617. https://doi.org/10.1021/acs.cgd.9b01341
  • Mei, C., Deshmukh, S. S., Cronin, J. T., Cong, S., Chapman, D. P., Lazaris, N., Sampaleanu, L. M., Schacht, U., Drolet-Vives, K., Ore, M. O., Morin, S., Carpick, B., Balmer, M., & Kirkitadze, M. (2019). Aluminum Phosphate Vaccine Adjuvant: Analysis of Composition and Size Using Off-Line and In-Line Tools. Computational and Structural Biotechnology Journal, 17, 1184–1194. https://doi.org/10.1016/j.csbj.2019.08.003
  • Nagy, B., Farkas, A., Gyürkés, M., Komaromy-Hiller, S., Démuth, B., Szabó, B. T., Nusser, D., Nagy, Z. K., & Marosi, G. (2017). In-line Raman spectroscopic monitoring and feedback control of a continuous twin-screw pharmaceutical powder blending and tableting process. International Journal of Pharmaceutics, 530(1–2), 21–29. https://doi.org/10.1016/j.ijpharm.2017.07.041
  • Hänchen, M., Prigiobbe, V., Baciocchi, R., & Mazzotti, M. (2008). Precipitation in the Mg-carbonate system—effects of temperature and CO2 pressure. Chemical Engineering Science, 63(4), 1012–1028. https://doi.org/10.1016/j.ces.2007.09.052