ReactRaman In-Situ Analysis
Understand Reaction Kinetics, Polymorph Transitions, and Mechanisms to Optimize Process Variables
In-situ Raman spectrometers enable scientists to measure reaction and process trends in real time, providing highly specific information about kinetics, polymorph transitions, mechanisms, and the influence of critical process parameters (CPP). With ReactRaman™, users directly track the concentration of both solid and liquid reactants, intermediates, products, and crystal forms as they change over the course of the experiment.
ReactRaman provides critical information to scientists as they research, develop, and optimize reactions and processes.
A high-performance in-situ Raman spectrometer, coupled with an intuitive, integrated software platform ensures reliable and high-quality reaction information from every experiment.
From data collection to analysis, ReactRaman with iC Raman software brings compositional analysis to every lab. Automated parameter selection provides accurate data collection, enabling scientists to get confident results. Right first time, every time, in every process for every user.
Comprehensive Reaction Understanding
In order to understand chemical reactions, chemists use Raman spectrometers to address the following:
- When does the reaction start? When does the reaction stop?
- What polymorph is being produced?
- What are the reaction kinetics, mechanisms, or crystallization processes?
- Did it react as expected? Did any byproducts form, and why?
- What happens if reaction temperature, dosing rates, or mixing rates change?
Continuous monitoring with in-situ Raman spectrometers allows users to trend components over time for a 'molecular video' of the reaction — making it easy to answer critical questions for reaction and process optimization.
Safety in Every Lab
With safety interlocks and 4 visual indicators, users work safely and easily identify when the laser is in use. ReactRaman and iC Raman will activate the laser only when all of the following interlocks are satisfied:
- SmartConnect™ Raman probe with electronic verification ensures connection to the spectrometer unit and safe operation
- Sampling optic is securely attached to the probe head
- Fiber conduit is intact
- Front panel laser key is in the ON position
- Remote interlock enagaged (i.e., for door or reactor lid)
Small Footprint, Big Performance
Class-leading performance with excellent stability and sensitivity in a compact, stackable package.
Deployment can be anywhere in the lab for batch or flow. A single robust connector guarantees alignment every time and inherent safety ensures worry-free measurements.
Flexible and Versatile Raman Spectrometers
In-Situ Raman Probes
Probe- and flow-based sampling technologies enable scientists to study liquid and solid phase chemistry in batch or continuous setups. Fit-for-purpose materials enable a wide range of temperatures, pressures, and chemistries.
Reaction Analysis Experts
As a company, METTLER TOLEDO has over 30 years of dedicated reaction analysis experience. This is our focus and our passion. We built this expertise into fit-for-purpose Raman spectrometers.
ReactRaman spectrometers work in a wide range of chemistries and conditions. Common Raman spectroscopy applications include:
Polymorph Detection in Carbamazepine
Reveal process mechanisms
In this example, ReactRaman follows the conversion of Carbamazepine anhydrate to the dihydrate form while showing the full transformation time.
Provide insight into distinguishing polymorphs
At times, polymorphs cannot be identified visibly. ReactRaman provides molecular information to help users understand more from their crystallization processes.
Measure form stability
Conversion of polymorphs can be monitored providing insight into stability of products.
Track progress for better yield and purity
Confirmation of optimal reaction or crystallization endpoint.
Quickly determine kinetics
First order reaction kinetics in one experiment.
An Integrated Approach for Comprehensive Understanding and Control
The ReactRaman spectrometer is part of an integrated family of products, which includes:
- ReactIR in-situ FTIR spectrometer
- EasyViewer particle size analyzer to view and measure particles in situ and in real time
- EasyMax, OptiMax, and RX-10 chemical synthesis reactors
Designed specifically for chemical and process development, these tools are combined with the iC Software Suite to provide comprehensive process understanding and control.
Raman Spectrometer FAQs
What is a Raman probe?
A Raman probe is a device used in Raman spectroscopy, a technique for analyzing the chemical composition of a sample by measuring the scattered light from its molecules. The probe typically consists of a laser, a lens system to focus the laser onto the sample, and a detector to measure the scattered light. The Raman effect, also known as Raman scattering, which is the basis of the technique, is the inelastic scattering of light by a sample, resulting in a shift in the wavelength of the scattered light. This shift is characteristic of the chemical bonds in the sample and can be used to identify the molecules present.
How do you use a Raman probe?
- Plug-in your ReactRaman
- Connect your Raman probe or sampling technology
- Place the Raman probe into your reaction
Corrosion-resistant materials are used in our in-situ Raman probes to increase the lifespan and reliability of the probe. These materials are able to withstand exposure to harsh chemical environments and protect the probe from damage, reducing the need for frequent replacement or maintenance. Additionally, using corrosion-resistant materials can also improve the accuracy and precision of the measurements taken by the probe.
What is Raman spectroscopy?
Is Raman or FTIR better for my application?
Raman and FTIR spectrometers offer molecular information about the structure and composition of chemical and biological samples. Because of the fundamental principles that govern each technology, both can yield complementary information. However, frequently one technology is a better choice, depending on the nature of the application.
Raman Spectrometer Resources
Raman Spectrometers in Journal Publications
Below is a selection of publications featuring Raman spectrometers
- Yang, L., Zhang, Y., Liu, P., Wang, C., Qu, Y., Cheng, J., & Yang, C. (2022). Kinetics and population balance modeling of antisolvent crystallization of polymorphic indomethacin. Chemical Engineering Journal, 428, 132591. https://doi.org/10.1016/j.cej.2021.132591
- Marzijarani, N. S., Fine, A., Dalby, S. M., Gangam, R., Poudyal, S., Behre, T., Ekkati, A. R., Armstrong, B. A., Shultz, C. S., Dance, Z. E. X., & Stone, K. H. (2021). Manufacturing Process Development for Belzutifan, Part 4: Nitrogen Flow Criticality for Transfer Hydrogenation Control. Organic Process Research & Development, 26(3), 533–542. https://doi.org/10.1021/acs.oprd.1c00231
- Wu, Y., Zhang, H., Wang, N., Chen, T., & Liu, Y. (2021). A Study on the Crystal Transformation Relationships of Valacyclovir Hydrochloride Polymorphs: Sesquihydrate, Form I, and Form II. Crystal Research and Technology, 2100084. https://doi.org/10.1002/crat.202100084
- Fang, C., Gong, J., Wu, S., Wang, J., & Gao, Z. (2020). Ultrasound-assisted intensified crystallization of L-glutamic acid: Crystal nucleation and polymorph transformation. Ultrasonics Sonochemistry, 68, 105227. https://doi.org/10.1016/j.ultsonch.2020.105227
- Østergaard, I., De Diego, H. L., Qu, H., & Nagy, Z. K. (2020). Risk-Based Operation of a Continuous Mixed-Suspension-Mixed-Product-Removal Antisolvent Crystallization Process for Polymorphic Control. Organic Process Research & Development, 24(12), 2840–2852. https://doi.org/10.1021/acs.oprd.0c00368
- Wang, Y. X., Yu, J., Wang, Y., Chen, Z., Dong, L., Cai, R., Hong, M., Long, X., & Yang, S. (2020). In situ templating synthesis of mesoporous Ni–Fe electrocatalyst for oxygen evolution reaction. RSC Advances, 10(39), 23321–23330. https://doi.org/10.1039/d0ra03111a
- Zhang, S., Zhou, L., Yang, W., Xie, C., Yang, X., Hou, B., Hao, H., Zhou, L., Bao, Y., & Yin, Q. (2020). An Investigation into the Morphology Evolution of Ethyl Vanillin with the Presence of a Polymer Additive. Crystal Growth & Design, 20(3), 1609–1617. https://doi.org/10.1021/acs.cgd.9b01341
- Mei, C., Deshmukh, S. S., Cronin, J. T., Cong, S., Chapman, D. P., Lazaris, N., Sampaleanu, L. M., Schacht, U., Drolet-Vives, K., Ore, M. O., Morin, S., Carpick, B., Balmer, M., & Kirkitadze, M. (2019). Aluminum Phosphate Vaccine Adjuvant: Analysis of Composition and Size Using Off-Line and In-Line Tools. Computational and Structural Biotechnology Journal, 17, 1184–1194. https://doi.org/10.1016/j.csbj.2019.08.003
- Nagy, B., Farkas, A., Gyürkés, M., Komaromy-Hiller, S., Démuth, B., Szabó, B. T., Nusser, D., Nagy, Z. K., & Marosi, G. (2017). In-line Raman spectroscopic monitoring and feedback control of a continuous twin-screw pharmaceutical powder blending and tableting process. International Journal of Pharmaceutics, 530(1–2), 21–29. https://doi.org/10.1016/j.ijpharm.2017.07.041
- Hänchen, M., Prigiobbe, V., Baciocchi, R., & Mazzotti, M. (2008). Precipitation in the Mg-carbonate system—effects of temperature and CO2 pressure. Chemical Engineering Science, 63(4), 1012–1028. https://doi.org/10.1016/j.ces.2007.09.052