- Application of a Semiautomated Crystallizer to Study Oiling-Out and Agglomeration Events—A Case Study in Industrial Crystallization Optimization. Xiaowen Zhao, Nicola J. Webb, Mark P. Muehlfeld, Alan L. Stottlemyer and Matthew W. Russell Cite this: Org. Process Res. Dev. 2021, 25, 3, 564–575, Publication Date: March 4, 2021 https://doi.org/10.1021/acs.oprd.0c00494
- Effective Control of Crystal Size via an Integrated Crystallization, Wet Milling, and Annealing Recirculation System. Wei Meng, Eric Sirota, Hanzhou Feng, Jonathan P. McMullen, Lorenzo Codan, and Aaron S. Cote, Cite This: Org. Process Res. Dev. 2020, 24, 2639−2650
- Safe Scale-up of an Oxygen-Releasing Cleavage of Evans Oxazolidinone with Hydrogen Peroxide, Andrew W. Glace, Benjamin M. Cohen, Darryl D. Dixon, Gregory L. Beutner, Dale Vanyo, Fulya Akpinar, Victor Rosso, Kenneth J. Fraunhoffer, Albert J. DelMonte, Edgar Santana, Christopher Wilbert, Frank Gallo, and William Bartels, Cite This: Org. Process Res. Dev. 2020, 24, 172−182
- A Convenient and Safer Synthesis of Diaminoglyoxime, Eric C. Johnson, Jesse J. Sabatini, and Nathaniel B. Zuckerman, Cite this: Org. Process Res. Dev. 2017, 21, 12, 2073–2075, Publication Date: November 29, 2017, https://doi.org/10.1021/acs.oprd.7b00329
RX-10 Reactor Control System
Automate Your Jacketed Lab Reactor
The RX-10™ chemical reactor control system automates jacketed laboratory reactors to ensure excellent reaction control and data-rich experimentation in every lab where process development and scale-up are important activities. The RX-10 allows you to control and record real-time data of essential reaction parameters such as temperature, mixing, dosing, and sampling.
The RX-10 reactor control manages third-party heating and cooling systems, stirrers, liquid dosing, autosamplers, and process analytical technology (PAT) tools in jacketed laboratory reactors while capturing important data and information. Scientists can reliably manage reactors on scales from milliliters to multiple liters by using an intuitive touchscreen interface that provides a unique user experience and lowers training costs and human error. The time required to combine and analyze analytical data, display and recognize significant reaction events, and provide intelligent reports is decreased with RX-10 reactor control.
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Jacketed Lab Reactor Intuitive UI
An intuitive, user-friendly touch screen seamlessly enables control and automation of your jacketed lab reactor (JLR) by programming thermostat temperature, stirring, liquid dosing, and sampling while integrating process analytical technology for data-rich experiments, day and night.
Extend control with computer-based software for remote monitoring, analysis, and reporting. JLR control systems allow scientists, process chemists, and engineers to automate tasks and workflows to perform more successful experiments, make informed decisions faster, and increase productivity.
The RX-10 provides an automation solution for reactor volumes larger than 1L and for various applications such as high-temperature or high-pressure needs.
Flexible and Simple Setup
RX-10 reactor control system is designed for plug-and-play operation and facilitates the quick connection to third-party accessories such as cryostats, stirring equipment, sensors, dosing, or sampling units—without configuration or need for larger investments.
Easy integration of sensors facilitates the use of additional measuring tools to gain more knowledge per reaction leading to better decisions. With SmartConnect™ technology, sensors and probes used with the JLR are recognized automatically. Existing sensors such as temperature probes, mass-flow sensors, and pressure sensors can be retrofitted for use with SmartConnect.
Connect Reactors with Third-Party Sensors
Extend jacketed lab reactor systems for automated control and data capture of third party devices including sensors, dosing, and sampling solutions with the Easy Control Box (ECB) accessory (purchased separately).
ECB provides dosing control capabilities and easily connects commercially available pumps and balances for automated preprogrammed gravimetric or volumetric dosing. The accessory has plug-and-play functionality with SmartConnect technology sensors. Control elements are automatically recognized making the configuration of the reactor systems a simple task.
Triple Your Productivity with Automation Features
Experiments can run and data can be captured without the scientist being present in the lab. Use your reactor safely day and night, thanks to the pre-programming and safety capabilities of the RX-10. Unattended task sequences or advanced recipes can be set up through the touchscreen or the powerful iC software suite.
The iC software and the touchscreen offer bi-directional control meaning scientists may apply both local and PC control from elsewhere to increase productivity, 24 hours a day. Experiment time available per day triples from 8 hours to 24 hours with the use of the RX-10 reactor control system.
In-Situ, Real-Time Analytics Tools
For Reaction Process Understanding to Make Better, Faster Decisions
For every experiment, all process data can be automatically collected from laboratory reactors and sensors, along with data from in-situ PAT instruments including pH, particle size analysis, FTIR spectroscopy, Raman spectroscopy, and unattended chemical reaction sampling.
Probe-based instruments in combination with RX-10 provide true insights into the reaction as it is occurring inside the reactor. In-situ reaction analysis enables chemists to continuously monitor their chemistry and reaction events. This provides a molecular video tracking of chemical bonds in real-time, that delivers critical information on reaction kinetics, mechanism, and path...
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Data Integrity and Traceability
All process data is collected, processed, reported, and securely stored to prevent information loss. Optional iC Data Center™ software makes sure that 100% of captured data is automatically stored in a safe place—no additional activity on the part of the operator is required.
The software suite reduces the time needed to merge process and analytical data, visualize and identify key reaction events and create smart reports. Automated reporting creates an MS Word and/or MS Excel report at the end of every experiment.
Automated reporting leads to better history logs, communication, and decisions for improved process development and optimization. Reports that are 100% accurate out-of-the-box can be attached to the traditional experiment documentation. Reduce transcription errors and lower documentation efforts while improving traceability for FDA filings.
RX-10 Reactor Control System
Supported Thermostats:
Huber, Julabo, and Lauda models with RS232 port
Supported Stirrer Motors:
Ika, Heidolph, ChemGlass, and J-KEM models with RS232 port
SmartConnect Port: Pt100, -10 to 10V, 0 to 20mA
Dimensions (LxHxW): 70 mm x 215 mm x 152 mm
Weight: 2.88 kg
Power Requirements: 100 – 240 VAC, 50/60Hz
Cable Length: 1 or 3m cable options
RX-10 Reactor Control System Testimonials
Dr. Carsten Griebel
Grünenthal
"The RX-10 unit is a versatile solution to optimize scale-up processes. In our lab, it has closed the gap between EasyMax/OptiMax synthesis workstations and multiliter JLR vessels. As main benefits, it provides a consistent lab workflow to the user and gives documentation of experiments along the whole scale-up workflow."
Andy Huygaerts
Janssen Pharmaceuticals
"Since we installed the RX-10, our jacketed lab reactors are used much more frequently. It is now easy and intuitive to program, manage and store data, and interpret experimental results. Safety limits on reactors reduce risk for the whole lab... In short, RX-10 makes our jobs easier and safer."
Gregor Schock
Grünenthal
"The RX-10 is a universal Jacketed Lab Reactor (JLR) control unit that works truly plug-and-play. My favorite function: It enables basic lab operations such as temperature, agitation, and dosing control as well as data capturing on existing equipment. A simple entry door into the world of lab automation!"
Reactor Control System FAQs
What is a reactor control system?
Synthesis reactors and automated lab reactors provide an innovative platform for chemical synthesis, development, and the kilo lab. These chemical synthesis and process development tools open new possibilities to discover synthetic pathways, explore conditions, and optimize reaction parameters. Depending on the operating volume and the goal of the investigation, researchers choose between different versions of synthesis reactors or automated lab reactor control systems.
The reactor control system coordinates the monitoring and control of temperature, dosage, and mixing through the use of reactor flux and thermal power measurements, reactivity control devices, and a collection of control system programs.
Will the RX-10 lab reactor control work with third-party accessories and sensors?
Yes, third-party accessories from Huber, Julabo, Lauda, Ika, and ChemGlass quickly connect to the RX-10 reactor control system. SmartConnect plug-and-play sensor port allows the connection of supported sensors and probes within minutes.
Do you offer fully automated synthesis workstations?
Yes, the intuitive EasyMax and OptiMax chemical synthesis reactors use an innovative, reliable heating and cooling technique. This ensures that the reaction temperature can be controlled quickly, accurately, and reproducibly without bulky cryostats. EasyMax and OptiMax provide safe, unattended control of reactions 24/7, and with an extensive reactor portfolio, they provide a sustainable investment for any chemistry lab. Information-rich data for every experiment provides researchers with the ability to make faster decisions leading to shorter development times and lower R&D costs.
How can I automate my jacketed lab reactor?
RX-10 reactor control system allows you to automate your jacketed lab reactor (JLR) setup, control and monitor chemical reactions, and perform unattended additions and sampling of reagents directly to/from your JLR. Simply connect your third-party accessories, sensors, and probes to the RX-10 and use the user-friendly intuitive touchscreen or PC-based software to control each device from a single interface.
- Preprogram multistep recipes
- Automate temperature and stirring control of your jacketed lab reactor during exothermic events
- Link peripherals such as stirrers, pumps, sensors, and probes