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Krystallisering og bundfældning

Krystallisering og bundfældning

Optimer krystalstørrelse, -udbytte og -renhed

Krystallisering og bundfældning
Procesudvikling ved krystallisering
Casestuier og litteratur og krystallisering

Mikroskopi til krystaller, partikler og dråber

Applikationer

Applikationsvejledning til krystalliseringsudvikling og opskalering

Optimization of Crystal Properties and Process Performance

Scientist recrystallize high value chemical compounds to obtain a crystal product with desired physical properties at optimal process efficiency. Seven steps are required to design the ideal recrystallization process from choosing the right solvent to obtaining a dry crystal product. This recrystallization guide explains step-by-step the procedure of developing a recrystallization process. It explains what information is required at each stage of recrystallization and outlines how to control critical process parameter

Solubility and Metastable Zone Width (mzw) Determination
Byggeblokkene i krystallisering

Opløselighedskurver er almindeligt anvendte for at illustrere forholdet mellem opløselighed, temperatur og type af opløsningsmiddel. Ved at plotte temperatur vs. opløselighed, kan forskerne skabe de nødvendige rammer for at udvikle den ønskede krystalliseringsproces. Når et passende opløsningsmiddel er valgt, bliver opløselighedskurven et vigtigt værktøj til udvikling af en effektiv krystalliseringsproces.

Crystal Nucleation and Growth
Den drivende kraft for krystalkimdannelse og vækst

Forskere og ingeniører får kontrol over krystalliseringsprocesser ved omhyggelig justering af niveauet af overmætning under processen. Overmætning er den drivende kraft ved kimdannelse i krystallisering og vækst og vil i sidste ende bestemme den endelige fordeling af krystalstørrelser.

Measure Crystal Size Distribution
Gør krystalliseringen bedre med inline partikelstørrelse, og -form, samt måling af partikeltal

In-process sondebaserede teknologier anvendes til at spore partikelstørrelse og formændringer ved fuld koncentration uden at fortynding eller ekstraktion er nødvendig. Ved at spore hastigheden og graden af ​​ændring i partikler og krystaller i realtid, kan de korrekte procesparametre til ydeevne ved krystallisering optimeres.

Crystallization Seeding Protocol
Design and Optimize Seeding Protocol for Improved Batch Consistency

Seeding is one of the most critical steps in optimizing crystallization behavior. When designing a seeding strategy, parameters such as: seed size, seed loading (mass), and seed addition temperature must be considered. These parameters are generally optimized based on process kinetics and the desired final particle properties, and must remain consistent during scale-up and technology transfer.

Particle Engineering and Wet Milling
Control Particle Size With High Shear Wet Milling

Milling of dry powders can cause significant yield losses and can generate dust, creating health and safety hazards. In response to this, wet milling produces particles with a specifically designed size distribution. It is now common to employ high shear wet milling to break large primary crystals and agglomerates into fine particles.

Anti-Solvent Addition on Supersaturation
How Solvent Addition Can Control Crystal Size and Count

In an antisolvent crystallization, the solvent addition rate, addition location and mixing impact local supersaturation in a vessel or pipeline. Scientists and engineers modify crystal size and count by adjusting antisolvent addition protocol and the level of supersaturation.

Temperature Effects Crystallization Size and Shape
Supersaturation Control Optimizes Crystal Size and Shape

Crystallization kinetics are characterized in terms of two dominant processes, nucleation kinetics and growth kinetics, occurring during crystallization from solution. Nucleation kinetics describe the rate of formation of a stable nuclei. Growth kinetics define the rate at which a stable nuclei grows to a macroscopic crystal. Advanced techniques offer temperature control to modify supersaturation and crystal size and shape.

Temperature Effects Crystallization Size and Shape
Scaling-Up Agitation, Dosing, and Crystallization

Changing the scale or mixing conditions in a crystallizer can directly impact the kinetics of the crystallization process and the final crystal size. Heat and mass transfer effects are important to consider for cooling and antisolvent systems respectively, where temperature or concentration gradients can produce inhomogeneity in the prevailing level of supersaturation.

Chemical Process Development & Scale-Up
Design Robust and Sustainable Chemical Processes For Faster Transfer To Pilot Plant and Production

Design Robust and Sustainable Chemical Processes For Faster Transfer To Pilot Plant and Production

Chemical Reaction Kinetics Studies
Study Chemical Reaction Rates and Measure Kinetics Inline

In situ chemical reaction kinetics studies provide an improved understanding of reaction mechanism and pathway by providing concentration dependences of reacting components in real-time. Continuous data over the course of a reaction allows for the calculation of rate laws with fewer experiments due to the comprehensive nature of the data.  Reaction Progression Kinetics Analysis (RPKA) uses in situ data under synthetically relevant concentrations and captures information throughout the whole experiment ensuring that the complete reaction behavior can be accurately described.

Polymorphism Identification and Control
Understand Polymorphism and the Impact of Process Parameters

Polymorphism is a common phenomenon with many crystalline solids in the pharmaceutical and fine chemical industry. Scientists deliberately crystallize a desired polymorph to improve isolation properties, help overcome downstream process challenges, increase bioavailability or to prevent patent conflicts. Identifying polymorphic and morphological transformations in-situ and in real time eliminates unexpected process upset, out of specification product and costly reprocessing of material.

Scientist recrystallize high value chemical compounds to obtain a crystal product with desired physical properties at optimal process efficiency. Seven steps are required to design the ideal recrystallization process from choosing the right solvent to obtaining a dry crystal product. This recrystallization guide explains step-by-step the procedure of developing a recrystallization process. It explains what information is required at each stage of recrystallization and outlines how to control critical process parameter

Solubility and Metastable Zone Width (mzw) Determination

Opløselighedskurver er almindeligt anvendte for at illustrere forholdet mellem opløselighed, temperatur og type af opløsningsmiddel. Ved at plotte temperatur vs. opløselighed, kan forskerne skabe de nødvendige rammer for at udvikle den ønskede krystalliseringsproces. Når et passende opløsningsmiddel er valgt, bliver opløselighedskurven et vigtigt værktøj til udvikling af en effektiv krystalliseringsproces.

Crystal Nucleation and Growth

Forskere og ingeniører får kontrol over krystalliseringsprocesser ved omhyggelig justering af niveauet af overmætning under processen. Overmætning er den drivende kraft ved kimdannelse i krystallisering og vækst og vil i sidste ende bestemme den endelige fordeling af krystalstørrelser.

Measure Crystal Size Distribution

In-process sondebaserede teknologier anvendes til at spore partikelstørrelse og formændringer ved fuld koncentration uden at fortynding eller ekstraktion er nødvendig. Ved at spore hastigheden og graden af ​​ændring i partikler og krystaller i realtid, kan de korrekte procesparametre til ydeevne ved krystallisering optimeres.

Crystallization Seeding Protocol

Seeding is one of the most critical steps in optimizing crystallization behavior. When designing a seeding strategy, parameters such as: seed size, seed loading (mass), and seed addition temperature must be considered. These parameters are generally optimized based on process kinetics and the desired final particle properties, and must remain consistent during scale-up and technology transfer.

Particle Engineering and Wet Milling

Milling of dry powders can cause significant yield losses and can generate dust, creating health and safety hazards. In response to this, wet milling produces particles with a specifically designed size distribution. It is now common to employ high shear wet milling to break large primary crystals and agglomerates into fine particles.

Anti-Solvent Addition on Supersaturation

In an antisolvent crystallization, the solvent addition rate, addition location and mixing impact local supersaturation in a vessel or pipeline. Scientists and engineers modify crystal size and count by adjusting antisolvent addition protocol and the level of supersaturation.

Temperature Effects Crystallization Size and Shape

Crystallization kinetics are characterized in terms of two dominant processes, nucleation kinetics and growth kinetics, occurring during crystallization from solution. Nucleation kinetics describe the rate of formation of a stable nuclei. Growth kinetics define the rate at which a stable nuclei grows to a macroscopic crystal. Advanced techniques offer temperature control to modify supersaturation and crystal size and shape.

Temperature Effects Crystallization Size and Shape

Changing the scale or mixing conditions in a crystallizer can directly impact the kinetics of the crystallization process and the final crystal size. Heat and mass transfer effects are important to consider for cooling and antisolvent systems respectively, where temperature or concentration gradients can produce inhomogeneity in the prevailing level of supersaturation.

Chemical Process Development & Scale-Up

Design Robust and Sustainable Chemical Processes For Faster Transfer To Pilot Plant and Production

Chemical Reaction Kinetics Studies

In situ chemical reaction kinetics studies provide an improved understanding of reaction mechanism and pathway by providing concentration dependences of reacting components in real-time. Continuous data over the course of a reaction allows for the calculation of rate laws with fewer experiments due to the comprehensive nature of the data.  Reaction Progression Kinetics Analysis (RPKA) uses in situ data under synthetically relevant concentrations and captures information throughout the whole experiment ensuring that the complete reaction behavior can be accurately described.

Polymorphism Identification and Control

Polymorphism is a common phenomenon with many crystalline solids in the pharmaceutical and fine chemical industry. Scientists deliberately crystallize a desired polymorph to improve isolation properties, help overcome downstream process challenges, increase bioavailability or to prevent patent conflicts. Identifying polymorphic and morphological transformations in-situ and in real time eliminates unexpected process upset, out of specification product and costly reprocessing of material.

Publikationer

Casestudier om fremstilling af krystallisering og bundfældning

White Papers

How to Optimize a Crystallization Step Using Simple Image Analysis
By quickly identifying unnecessary hold times and determining how cooling rate influences crystal growth and nucleation, the cycle time for an interme...
Forstå krystallisering med in situ-mikroskopi
Dynamiske mekanismer, der er afgørende for at forstå krystalliseringsprocesser, kan nu observeres med in situ-mikroskopi. Et white paper forklarer, hv...
Effektiv procesudvikling ved krystallisering
Kvaliteten af en krystalliseringsproces har stor indflydelse på kvaliteten af det endelige produkt. Vores nye white paper introducerer dig for grundla...
Strategier til kontrol af krystalstørrelsesfordeling
Dette white paper behandler strategier for at optimere krystalstørrelsesfordeling under procesudvikling og fremstilling.
Opnå bedre industriel krystallisering
Industriel krystallisering er et vigtigt adskillelses- og rensningstrin i den kemiske industri. Et white paper viser, hvordan inline-partielteknologi...
Seeding a Crystallization Process
Seeding is a key step in optimizing a crystallization process, ensuring a consistent filtration rate, yield, polymorphic form and particle size distri...
Scale-up of Batch Crystallization From Lab to Plant
Real-time monitoring of crystallization is shown to provide benefits leading to improved methods for process development, optimization and scale-up. T...
Best Practices For Crystallization Development
This white paper demonstrates the methodology chemists use to optimize critical crystallization parameters such as: Temperature profile Addition rates...
Particle Size Analysis for Process Optimization
This white paper introduces some of the most common particle size analysis approaches and how they can be deployed for the effective delivery of high...

Webseminarer

PAT-baseret design for kontinuerte krystalliseringer
En designmetode med mulighed for PAT (Process Analytical Technology), der giver mulighed for hurtig evaluering af forskellige kontinuerte propstrøms-...
Eliminating Micronization Using Fine Particle Crystallization
Crystal engineering is applied when the crystal size distribution is too large to meet downstream specifications. By designing the crystallization to...
Calibration Free Supersaturation Assessment
The quantitative use of in situ ATR-FTIR for real time supersaturation assessment has been extremely well defined within the literature. However, thes...
metastable zone width (MSZW) crystallization
The webinar focuses on a semi-quantitative method for the optimization and scale-up of hydrodynamically limited anti-solvent crystallization process....
Improving Crystallization and Precipitation
This webinar introduces case studies and highlights best practices used to overcome crystallization and precipitation challenges. The focus will be on...

Applikationsbemærkninger

In-Process Characterization of Antisolvent Crystallization
Ensure fast and efficient scale-up by optimizing crystallization early in development. Target particle size specifications to speed up downstream proc...
Polymorph and Pseudo-polymorph Transition in-process monitoring of habit change
Improve purity by ensuring total polymorphic form conversion. Enhance process robustness by monitoring crystallization processes in real time. Charact...

Relaterede produkter

Teknologi til krystalliseringsudvikling og opskalering

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