FTIR Spectroscopy with In Situ ReactIR For Reaction Analysis

    FTIR Spectroscopy with In Situ Reaction Monitoring

    Understand Reaction Kinetics, Pathway and Mechanism with Real Time FTIR Spectroscopy

    In Situ FTIR Spectroscopy for Lab and Process
    ReactIR in situ Fourier Transform Infrared (FTIR) spectroscopy delivers the performance, sampling versatility and intuitive reaction analysis software for information and understanding about chemistry.  ReactIR in situ FTIR Spectroscopy provides real-time reaction monitoring in both lab and process environments.  Attenuated Total Reflection (ATR) provides data about conversion, intermediates, reaction initiation, and endpoint.

    Products and Specs

    Chemical Reaction Monitoring in real time

     
    Products and Specs
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    For Use In
    Material No.: 14000003
    See details
    For Use InLaboratory
    SoftwareiC IR
    DetectorLN2 NCT;SE MCT
    Optical Range (Base Unit)4000 – 650 cm-1
    Purge RequirementNo
    Dimensions (WxHxD)180 mm x 274 mm x 249 mm
    Weight20 lb (9 kg)
    CommunicationUSB 2.0
    Resolution4 cm-1 maximum
    Probe Optical Window2500 – 650 cm-1 maximum (Fiber Probe)
    Wetted MaterialsAlloy C22;Diamond or Silicon;Gold
    Probe Pressure (Maximum)69bar (6.3 & 9.5mm Fiber Probe);107bar (Sentinel)
    Probe Temperature (Maximum)180°C (Fiber Probe);200°C (Sentinel)
    Safety CertificationEMC Directive 2004/109/EC, Low Voltage Directive 2006/95/IEC
    Probe pH Range1 – 14 (Diamond);1 – 9 (Silicon)
    Material No.: 14000003
    See details
    For Use InLaboratory
    SoftwareiC IR
    DetectorLN2 NCT;SE MCT
    Optical Range (Base Unit)4000 – 650 cm-1
    Purge RequirementNo
    Dimensions (WxHxD)180 mm x 274 mm x 249 mm
    Weight20 lb (9 kg)
    CommunicationUSB 2.0
    Resolution4 cm-1 maximum
    Probe Optical Window2500 – 650 cm-1 maximum (Fiber Probe)
    Wetted MaterialsAlloy C22;Diamond or Silicon;Gold
    Probe Pressure (Maximum)69bar (6.3 & 9.5mm Fiber Probe);107bar (Sentinel)
    Probe Temperature (Maximum)180°C (Fiber Probe);200°C (Sentinel)
    Safety CertificationEMC Directive 2004/109/EC, Low Voltage Directive 2006/95/IEC
    Probe pH Range1 – 14 (Diamond);1 – 9 (Silicon)
    Material No.: 14170003
    See details
    For Use InLaboratory
    SoftwareiC IR
    DetectorLN2 NCT
    Optical Range (Base Unit)4000 – 650 cm-1
    Purge RequirementYes
    Dimensions (WxHxD)216 mm x 381 mm x 279 mm
    Weight35 lb (16 kg)
    CommunicationUSB cable
    Resolution4 cm-1 maximum
    Probe Optical Window2500 – 650 cm-1 maximum (Fiber Probe);4000 – 650 cm-1 (Sentinel)
    Wetted MaterialsAlloy C22;Diamond or Silicon;Gold
    Probe Pressure (Maximum)107bar (Sentinel);69bar (6.3 & 9.5mm Fiber Probe)
    Probe Temperature (Maximum)180°C (Fiber Probe);200°C (Sentinel)
    Safety CertificationEMC Directive 2004/109/EC, Low Voltage Directive 2006/95/IEC
    Probe pH Range1 – 14 (Diamond);1 – 9 (Silicon)
    Material No.: 14474487
    See details
    For Use InLab, Pilot Plant or Production
    SoftwareiC IR;iC Process
    DetectorDTGS;SE MCT
    Optical Range (Base Unit)4000 – 650 cm-1
    Purge RequirementYes
    Dimensions (WxHxD)457 mm x 523 mm x 310 mm
    Weight37 kg
    CommunicationEthernet TCP/IP
    Resolution4 cm -1 maximum
    Probe Optical Window2500 – 650 cm-1 maximum (Fiber Probe);4000 – 650 cm-1 (Sentinel)
    Wetted MaterialsAlloy C-22;Diamond or Silicon;Gold
    Probe Pressure (Maximum)107bar (Sentinel);69bar (6.3 & 9.5mm Fiber Probe)
    Probe Temperature (Maximum)180°C (Fiber Probe);200°C (Sentinel)
    Safety CertificationArea Classification – NON-HAZARDOUS, MET Mark E112462, UL61010-1 & CSA C22.2 No. 61010-1
    Probe pH Range1 – 14 (Diamond);1 – 9 (Silicon)
    Material No.: 14474485
    See details
    For Use InLab, Pilot Plant or Production
    SoftwareiC IR;iC Process
    DetectorDTGS;SE MCT
    Optical Range (Base Unit)4000 – 650 cm-1
    Purge RequirementYes
    Dimensions (WxHxD)457 mm x 774 mm x 310 mm
    Weight45 kg
    CommunicationLC terminated Ethernet TCP/IP, duplex fiber optic
    Resolution4 cm -1 maximum
    Probe Optical Window2500 – 650 cm-1 maximum (Fiber Probe);4000 – 650 cm-1 (Sentinel)
    Wetted MaterialsAlloy C-22;Diamond or Silicon;Gold
    Probe Pressure (Maximum)107bar (Sentinel);69bar (6.3 & 9.5mm Fiber Probe)
    Probe Temperature (Maximum)180°C (Fiber Probe);200°C (Sentinel)
    Safety CertificationArea Classification – HAZARDOUS, MET Mark E112462, UL61010-1 & CSA C22.2 No. 61010-1;ATEX listing - TRAC12ATEX0001X, Equipment marking - Ex d op pr px [ia IIC] IIB+H2 T4 Gb;NFPA 496, Class I, Division 1, Groups B, T4
    Probe pH Range1 – 14 (Diamond);1 – 9 (Silicon)
    Comparison

    Documentation

    FTIR Spectroscopy for Chemical Reaction Monitoring

    Datasheets

    ReactIR 15
    Study reaction progression and gain specific information about reaction initiation, conversion, intermediates and endpoint.
    ReactIR 45m
    A real-time, in situ mid-infrared FTIR system monitors reactive chemistry to track reactants, products and intermediates under actual reaction conditi...
    ReactIR 45P In Situ Process FTIR
    Successfully move processes from lab to pilot plant and production with in situ process FTIR spectroscopy. Gain in-depth reaction understanding, ident...
    ReactIR Sampling Technology
    ReactIR in situ sampling technology assures usability in a wide range of batch and continuous reaction conditions.
    ReactIR Instrument Performance Assurance (IPA) Module
    Validate ReactIR wavenumber accuracy and calibrate to a Polystyrene standard certified by the National Institute of Standards and Technology (NIST) fo...

    ReactIR Citations

    ReactIR Citation List
    Continuous measurements from infrared spectroscopy are widely used for obtaining reaction profiles, which are used to calculate reaction rates. This...

    Brochures

    ReactIR Brochure
    Understand reaction chemistry with ReactIR In Situ FTIR spectroscopy

    Applications

    Chemical Synthesis
    Chemists working in chemical synthesis discover and develop innovative chemical reactions and processes.
    Chemical Process Development & Scale-Up
    Design Robust and Sustainable Chemical Processes For Faster Transfer To Pilot Plant and Production
    Process Analytical Technology (PAT)
    Process Analytical Technology (PAT) is changing the way R&D, scale-up, and manufacturing are performed. PAT transforms productivity, improves safety,...
    Measuring Polymerization Reactions
    Measuring and understanding polymerization reactions, mechanisms, kinetics, reactivity ratios, and activation energies lead researchers to employ in s...
    Fermentation and BioProcessing
    Characterize & Optimize Fermentation & Bioprocesses in Real Time to Maximize Production
    Continuous Flow Chemistry
    Continuous flow chemistry opens options with exothermic synthetic steps that are not possible in batch reactors, and new developments in flow reactor...
    Anti-Solvent Addition on Supersaturation
    In an anti-solvent crystallization, the solvent addition rate, addition location and mixing impact local supersaturation in a vessel or pipeline. Scie...
    Temperature Effects Crystallization Size and Shape
    The cooling profile has a major impact on supersaturation and kinetics of crystallization Process temperature is optimized to match the surface are o...
    Chemical Reaction Kinetics Studies
    In situ chemical reaction kinetics studies provide an improved understanding of reaction mechanism and pathway by providing concentration dependences...

    Related Products and Solutions

    chemical synthesis reactors
    Chemical synthesis reactors increase productivity in the lab
    EasySampler
    EasySampler was designed to eliminate these challenges by providing an automated and robust inline method of taking representative samples from reacti...
    Inline Particle Size Distribution & Particle Shape Analysis
    Understand, Optimize & Control Particle & Droplets With Real-Time In Situ Particle System Characterization
    Reaction Calorimeters RC1
    Reaction Calorimetry For Screening, Process Development, and Process Safety Studies

    Software

    iC IR Software
    Spectroscopic data increases chemical understanding and knowledge of the chemical process, including reaction initiation, endpoint, mechanism, pathway...
    iC Kinetics Software
    Optimize chemical reactions with a fast graphical way to describe the characteristics of a chemical reaction and create a kinetic model. This model c...
    iC Process Software
    Monitor critical control parameters determined in the laboratory to production environment. Supports industry standard communication protocols for in...
    iC Data Center
    Capture, Prepare, Share Experimental Data

    Posters

    Monitoring of Reaction Mechanisms
    Data is collected in the mid-infrared spectral region, which provide a characteristic fingerprint absorbance that is associated with fundamental vibr...

    Services

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    Explore our Services - Tailored to Fit your Equipment

    We support and service your measurement equipment through its entire life-cycle, from installation to preventive maintenance and calibration to equipment repair.

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    FAQ

    FTIR Spectroscopy with ReactIR FAQ

    Why use Mid-Infrared ATR-FTIR Spectroscopy?

    In many instances, reaction understanding requires the construction of accurate reaction profiles for each species that are expressed as concentration versus time, leading to the determination of reaction kinetics.  In Situ Mid-Infrared ATR-FTIR Spectroscopy is an ideal technique to provide this information, as it allows the rapid collection of detailed reaction profiles.


    What advantages does Mid-Infrared ATR-FTIR Spectroscopy bring to reaction analysis?

    Mid-Infrared ATR-FTIR Spectroscopy brings a couple of advantages to reaction analysis.  First, the use of the fingerprint region of the mid-infrared enables the individual tracking of chemical species, which in turn provides clues to the mechanism of the reaction.  Second, Beer's Law gives the connection between the measured absorbance of the reaction species and its concentration.  This relationship means we can use an offline measurement to determine the concentration of an offline sample, and then use that data point to scale the mid-infrared profile.  There is a correlation between the concentration measurement of offline samples and the measured shape of the in situ samples.

    Why use Mid-Infrared ATR-FTIR Spectroscopy instead of alternative techniques?

    Mid-infrared attenuated total reflectance (ATR) technology offers numerous advantages over alternative analytical methods, including other molecular spectroscopy techniques.  Researchers and scientists improve chemical development by leveraging these advantages, including:

    • Immersible for direct insertion into reaction vessel for in situ, continuous, real-time measurements
    • No extractive sampling required, providing the ability to measure chemistry in its natural environment
    • Impervious to bubbles or solids, making it ideal for hydrogenations or any heterogeneous reactions
    • Suitable for aqueous chemistry
    • Non-destructive, preserving the integrity of the chemical reaction
    • Adheres to Beer-Lambert law, enabling both qualitative and quantitative measurements

    Instantaneous information can be gained about a reaction from ReactIR FTIR spectroscopy because it is an in situ technique.  This is a key benefit to obtaining further insights into reaction behavior, particularly where transient species are involved.

    Why is the data generated from Mid-Infrared ATR-FTIR Spectroscopy so important?

    The reason why the data is so important is because of its continuous nature.  With ReactIR FTIR Spectroscopy, data collection is automated, typically generating concentration information every minute, even as fast as four times every second.  This means that rather than running a large number of reactions to understand rate dependencies, just a few experiments can provide the necessary information to determine the driving forces of a reaction supporting reaction mechanistic theory.  This means that research can progress at an accelerated rate.  In addition, the data is often more accurate than data analyzed by offline techniques as there is no possible alteration of the molecules by preparation for analysis, or by exposing it to an enviroment other than that within the reaction vessel.

    What industries use ReactIR FTIR Spectroscopy?

    ReactIR FTIR Spectroscopy is used in the pharmaceutical, chemical, and petrochemical industries as well as in academic research.

    What is ReactIR FTIR Spectroscopy used for in the Pharmaceutical industry?

    • Organic Synthesis
    • Grignard
    • Hydrogenations
    • Crystallization
    • Asymmetric Catalysis
    • Halogenations
    • Enzymatic Catalysis
    • Cross Coupling Reactions
    • Organometallic Chemistry
    • Solution Phase and Heterogeneous Catalysis

    What is ReactIR FTIR Spectroscopy used for in the Chemical industry?

    • Intermediates
    • Surfactants
    • Flavors and Fragrances
    • Coatings/Pigments
    • Agrochemicals
    • Initiators
    • Bulk Chemicals
    • Isocyanate Chemistry
    • EO/PO
    • Highly Oxidizing Reactions
    • Hydroformylation
    • Catalytic Processes
    • Phosgenations
    • Esterifications

    What is ReactIR FTIR Spectroscopy used for in Academic Research?

    • Metal-Mediated Chemistry
    • Catalysis
    • C-H Activation
    • Mechanistic Studies
    • Reaction Kinetics
     
     
     
     
     
     
     
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