Hydroformylation, or oxo synthesis/process, is important for the production of olefins to aldehydes and aldehydes from alkenes. Hydroformylation reactions are performed at high pressure and can be challenging to sample due to the extreme reaction conditions, as well as the toxic, flammable, and reactive raw materials and reagents.
In a hydroformylation, the catalyst is typically an expensive part of the process. Air oxidation of the active species is the first step in losing the valuable metal catalyst. In some cases, converting the catalyst back to active form can be accomplished, but at a cost to production and resources.
The ability to monitor the catalyst for activity and selectivity is key. Real-time in situ FTIR spectroscopy (ReactIR) enables the reaction to be followed without the need for sampling. It provides in-depth knowledge about the catalyst by monitoring the metal carbonyl bands in the 2200-1900cm-1 region where few other species absorb. The H2/CO ratio also affects the amount of active catalyst. Investigating different gas ratios and environments provides the ability to gain insight into the catalyst mechanism and selectivity. Catalyst intermediates can also be observed to elucidate their impact on product yield and purity.
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Bob Cooley, GlaxoSmithKline
Gain insights into difficult chemistryGain insights into reaction performance and variableswhen conditions prohibit or complicate extractive sampling...
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'How to do more with less?' is a constant topic in chemical development laboratories as researchers need to quickly and cost-effectively deliver chemi...
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The use of Fourier Transform Infrared (FTIR) spectroscopy to understand the effect of catalyst, substrate, and carbenoid precursor on the rate and eff...
There is an increasing demand to run reactions at elevated pressures. Due to the nature of pressure chemistry, the reaction mass typically consists of...
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