What is Important to Understand & Monitor?
Hydrogenation is one of the leading chemical reactions. In a single step, a hydrogenation reaction allows the formation of C-C simple bonds from alkenes and alkynes, C-O bonds from ketones, and aldehyde or esters, and C-N (amines) from imines or nitriles, etc. Hydrogenation is influenced by several factors including type of catalyst, catalyst concentration, solvent, substrate purity, temperature, and pressure. When considering catalyst performance, four parameters are typically considered: yield, selectivity, TON/TOF, activity, and stability. By collecting analytical data continuously throughout each experiment, chemists remove barriers to get the best understanding from each reaction. Understanding reaction initiation, mechanism, conversion, and endpoint, as well as impurity or byproduct profile, enables faster decisions about what changes to chemical conditions or process parameters need to be made.