1. Nucleation
Achieve consistent primary nucleation and avoid secondary nucleation events.
2. Growth
Enhance growth over nucleation to increase crystal size.
3. Oiling Out
Determine the phase diagram and avoid conditions where oiling out occurs.
4. Agglomeration
Avoid agglomeration through solvent selection and parameter control.
5. Breakage
Avoid unwanted breakage and addition and control desired wet-milling.
6. Seeding
Optimize seeding protocol to deliver desired particle properties.
7. Polymorph Transformation
Navigate the phase diagram to produce the desired form.
