Process Analytical Technology PAT | R&D, Scale-up & Manufacturing

Process Analytical Technology (PAT)

PAT is Changing Chemical Process Development, Scale-up, and Manufacturing

Process Analytical Technology (PAT)

Process Analytical Technology in R&D
Process Analytical Technology (PAT)
In Situ Reaction Analysis Tools
Inline Particle Characterization
Heat Flow Calorimetry in PAT

Applikasjoner

Measure Crystal Size Distribution
Bedre krystallisering med inline måling av partikkelstørrelse, form og antall

Sondebasert teknologi i prosesser brukes til å spore partikkelstørrelse og formendringer ved full konsentrasjon, uten at det er nødvendig med fortynning eller raffinering. Ved å spore hastigheten og graden av endringer i partikler og krystaller i sanntid, kan de riktige prosessparameterne for krystalliseringsytelse optimeres.

Krystallisering og utfelling
Optimer krystallstørrelse, utvinning og renhet

Optimering og oppskalering av krystallisering og utfelling for å produsere et produkt som konsekvent overholder målene for renhet, resultat, form og partikkelstørrelse kan være en av de største utfordringene for prosessutvikling.

Chemical Process Development & Scale-Up
Design Robust and Sustainable Chemical Processes For Faster Transfer To Pilot Plant and Production

Design Robust and Sustainable Chemical Processes For Faster Transfer To Pilot Plant and Production

urenhetsprofilering
Continuous Automated Reaction Sampling Improves Productivity and Understanding for Chemists

Knowledge of impurity kinetics and mechanism of formation is important in determining reaction end-point in chemical and process development studies. Accurate, reproducible, and representative reactions samples are necessary for these studies.

kjemisk reaksjonskinetikk
Study Chemical Reaction Rates and Measure Kinetics Inline

Flow Chemistry
Improve Safety, Reduce Cycle Time, Increase Quality and Yield

Continuous flow chemistry opens options with exothermic synthetic steps that are not possible in batch reactors, and new developments in flow reactor design provide alternatives for reactions that are mixing limited in batch reactors. This can often result in better product quality and higher yield.  When coupled with Process Analytical Technology (PAT), flow chemistry allows for rapid analysis, optimization, and scale-up of a chemical reaction.

Grignard Reaction Mechanisms
Understand and Control Exothermic Events

Grignard reactions are one of the most important reaction classes in organic chemistry. Grignard reactions are useful for forming carbon-carbon bonds. Grignard reactions form alcohols from ketones and aldehydes, as well as react with other chemicals to form a myriad of useful compounds. Grignard reactions are performed using a Grignard reagent, which is typically a alkyl-, aryl- or vinyl- organomagnesium halide compound. To ensure optimization and safety of Grignard reactions in research, development and production, in situ monitoring and understanding reaction heat flow is important.

Formulations and Product Development
Develop Solid and Liquid Formulations With Desired Disintegration and Dissolution Profiles

Develop Solid and Liquid Formulations With Desired Disintegration and Dissolution Profiles

Measure Crystal Size Distribution

Sondebasert teknologi i prosesser brukes til å spore partikkelstørrelse og formendringer ved full konsentrasjon, uten at det er nødvendig med fortynning eller raffinering. Ved å spore hastigheten og graden av endringer i partikler og krystaller i sanntid, kan de riktige prosessparameterne for krystalliseringsytelse optimeres.

Krystallisering og utfelling

Optimering og oppskalering av krystallisering og utfelling for å produsere et produkt som konsekvent overholder målene for renhet, resultat, form og partikkelstørrelse kan være en av de største utfordringene for prosessutvikling.

Chemical Process Development & Scale-Up

Design Robust and Sustainable Chemical Processes For Faster Transfer To Pilot Plant and Production

urenhetsprofilering

Knowledge of impurity kinetics and mechanism of formation is important in determining reaction end-point in chemical and process development studies. Accurate, reproducible, and representative reactions samples are necessary for these studies.

Flow Chemistry

Continuous flow chemistry opens options with exothermic synthetic steps that are not possible in batch reactors, and new developments in flow reactor design provide alternatives for reactions that are mixing limited in batch reactors. This can often result in better product quality and higher yield.  When coupled with Process Analytical Technology (PAT), flow chemistry allows for rapid analysis, optimization, and scale-up of a chemical reaction.

Grignard Reaction Mechanisms

Grignard reactions are one of the most important reaction classes in organic chemistry. Grignard reactions are useful for forming carbon-carbon bonds. Grignard reactions form alcohols from ketones and aldehydes, as well as react with other chemicals to form a myriad of useful compounds. Grignard reactions are performed using a Grignard reagent, which is typically a alkyl-, aryl- or vinyl- organomagnesium halide compound. To ensure optimization and safety of Grignard reactions in research, development and production, in situ monitoring and understanding reaction heat flow is important.

Formulations and Product Development

Develop Solid and Liquid Formulations With Desired Disintegration and Dissolution Profiles

Publikasjoner

White Papers

Effective Crystallization Process Development
The quality of a crystallization process greatly influences the quality of the final product. Our new white paper introduces you to the fundamentals o...
How to Optimize a Crystallization Step Using Simple Image Analysis
By quickly identifying unnecessary hold times and determining how cooling rate influences crystal growth and nucleation, the cycle time for an interme...
Process FTIR For Safe Operation of Sodium Borohydride Reduction
John O'Reilly of Roche Ireland discusses sustainable Process Analytical Technology (PAT) system using Process FTIR for the safe operation of a sodium...
In Situ Monitoring of Chemical Reactions
'How to do more with less?' is a constant topic in chemical development laboratories as researchers need to quickly and cost-effectively deliver chemi...
Rapid Analysis of Continuous Reaction Optimization Experiments
The white paper - Rapid Analysis of Continuous Reaction Optimization Experiments - discusses how to optimize chemical reactions.
Effective Design of Experiment Studies
This paper describes the Design of Experiments (DoE) approach and how it is used to identify the relationship between parameters, defining optimal set...
Risks From Rising Temperature
In chemical process scale-up, understanding temperature change and the associated heat that is accumulated by the reaction are critical to process saf...
PAT for Emulsions
Use PAT for emulsions and suspension characterization without the need for sampling or sample prep.
Monitor Tablet & Granule Disintegration
The role of in-process particle measurement to complement traditional API dissolution studies is presented. The use of particle size and count measure...
Particle Size Analysis for Process Optimization
This white paper introduces some of the most common particle size analysis approaches and how they can be deployed for the effective delivery of high...

On-Demand Webinars

Breaking Barriers to Manufacturing Innovation
Frederic Buono discusses how Boehringer Ingelheim uses continuous flow technology to break barriers in manufacturing innovation.
Crystallization Image Analysis
Presented by Prof. Zoltan Nagy of Purdue University, this talk provides an overview of recent advances of applications for in situ imaging and image a...
Flow and Batch Chemistry Monitoring
Charles Goss presents examples illustrating how GlaxoSmithKline (GSK) monitors flow and batch chemistry unit operations in both laboratory and pilot p...
Liquid-Liquid Phase Separation
This presentation describes a strategy employed to design and develop robust, scalable crystallization processes that avoids Liquid-Liquid Phase Separ...
New Tools For Continuous Flow Chemistry
Andrea Adamo of MIT and Zaiput Flow Technologies discusses new tools for continuous flow chemistry advancement.
Agglomeration & Crystallization Using Particle Measurement
This presentation details how using data from in situ particle vision and measurement tools can be used to determine particle size and shape trends re...
Lubrizol Process Development and Scale-up
This webinar focuses on how to improve process development and scale-up by leveraging calorimetry and in situ process analysis. In order to provide t...
Merck Chemical Process Development
Shane Grosser discusses how Merck's Process Development Intensification Laboratory develops new tools and methods to increase the speed and decrease t...

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