Krystallisering og utfelling
Krystallisering og utfelling

Krystallisering og utfelling

Optimer krystallstørrelse, utvinning og renhet

Krystallisering og utfelling
Krystalliseringsprosessutvikling
Case-studier i krystallisering

Mikroskopi for krystaller, partikler og dråper

Applikasjoner

Application Guide to Crystallization Development and Scale-up

Optimization of Crystal Properties and Process Performance

Scientist recrystallize high value chemical compounds to obtain a crystal product with desired physical properties at optimal process efficiency. Seven steps are required to design the ideal recrystallization process from choosing the right solvent to obtaining a dry crystal product. This recrystallization guide explains step-by-step the procedure of developing a recrystallization process. It explains what information is required at each stage of recrystallization and outlines how to control critical process parameter

Solubility and Metastable Zone Width (mzw) Determination
Krystalliseringens byggeklosser

Oppløselighetskurver brukes ofte til å illustrere forholdet mellom løselighet, temperatur og type løsemiddel. Ved å plotte temperatur mot løselighet kan forskere opprette rammeverket som trengs for å utvikle ønsket krystalliseringsprosess. Så snart et egnet løsemiddel er valgt, blir oppløselighetskurven et kritisk verktøy for utviklingen av en effektiv krystalliseringsprosess.

overmetningskrystallisering
Drivkraften bak krystallkjernedannelse og -vekst

Forskere og teknikere tar kontroll over krystalliseringsprosesser ved å nøye justere overmetningsnivået under prosessen. Overmetning er drivkraften for kjernedannelse og vekst i krystallisering og vil til syvende og sist avgjøre den endelige krystallstørrrelsedistribusjonen.

Measure Crystal Size Distribution
Bedre krystallisering med inline måling av partikkelstørrelse, form og antall

Sondebasert teknologi i prosesser brukes til å spore partikkelstørrelse og formendringer ved full konsentrasjon, uten at det er nødvendig med fortynning eller raffinering. Ved å spore hastigheten og graden av endringer i partikler og krystaller i sanntid, kan de riktige prosessparameterne for krystalliseringsytelse optimeres.

Crystallization Seeding Protocol
Design and Optimize Seeding Protocol for Improved Batch Consistency

Seeding is one of the most critical steps in optimizing crystallization behavior. When designing a seeding strategy, parameters such as: seed size, seed loading (mass), and seed addition temperature must be considered. These parameters are generally optimized based on process kinetics and the desired final particle properties, and must remain consistent during scale-up and technology transfer.

Particle Engineering and Wet Milling
Control Particle Size With High Shear Wet Milling

Milling of dry powders can cause significant yield losses and can generate dust, creating health and safety hazards. In response to this, wet milling produces particles with a specifically designed size distribution. It is now common to employ high shear wet milling to break large primary crystals and agglomerates into fine particles.

Anti-Solvent Addition on Supersaturation
How Solvent Addition Can Control Crystal Size and Count

In an antisolvent crystallization, the solvent addition rate, addition location and mixing impact local supersaturation in a vessel or pipeline. Scientists and engineers modify crystal size and count by adjusting antisolvent addition protocol and the level of supersaturation.

Temperature Effects Crystallization Size and Shape
Supersaturation Control Optimizes Crystal Size and Shape

Crystallization kinetics are characterized in terms of two dominant processes, nucleation kinetics and growth kinetics, occurring during crystallization from solution. Nucleation kinetics describe the rate of formation of a stable nuclei. Growth kinetics define the rate at which a stable nuclei grows to a macroscopic crystal. Advanced techniques offer temperature control to modify supersaturation and crystal size and shape.

Temperature Effects Crystallization Size and Shape
Scaling-Up Agitation, Dosing, and Crystallization

Changing the scale or mixing conditions in a crystallizer can directly impact the kinetics of the crystallization process and the final crystal size. Heat and mass transfer effects are important to consider for cooling and antisolvent systems respectively, where temperature or concentration gradients can produce inhomogeneity in the prevailing level of supersaturation.

Chemical Process Development & Scale-Up
Design Robust and Sustainable Chemical Processes For Faster Transfer To Pilot Plant and Production

Design Robust and Sustainable Chemical Processes For Faster Transfer To Pilot Plant and Production

kjemisk reaksjonskinetikk
Study Chemical Reaction Rates and Measure Kinetics Inline

Polymorphism Identification and Control
Understand Polymorphism and the Impact of Process Parameters

Polymorphism is a common phenomenon with many crystalline solids in the pharmaceutical and fine chemical industry. Scientists deliberately crystallize a desired polymorph to improve isolation properties, help overcome downstream process challenges, increase bioavailability or to prevent patent conflicts. Identifying polymorphic and morphological transformations in-situ and in real time eliminates unexpected process upset, out of specification product and costly reprocessing of material.

Scientist recrystallize high value chemical compounds to obtain a crystal product with desired physical properties at optimal process efficiency. Seven steps are required to design the ideal recrystallization process from choosing the right solvent to obtaining a dry crystal product. This recrystallization guide explains step-by-step the procedure of developing a recrystallization process. It explains what information is required at each stage of recrystallization and outlines how to control critical process parameter

Solubility and Metastable Zone Width (mzw) Determination

Oppløselighetskurver brukes ofte til å illustrere forholdet mellom løselighet, temperatur og type løsemiddel. Ved å plotte temperatur mot løselighet kan forskere opprette rammeverket som trengs for å utvikle ønsket krystalliseringsprosess. Så snart et egnet løsemiddel er valgt, blir oppløselighetskurven et kritisk verktøy for utviklingen av en effektiv krystalliseringsprosess.

overmetningskrystallisering

Forskere og teknikere tar kontroll over krystalliseringsprosesser ved å nøye justere overmetningsnivået under prosessen. Overmetning er drivkraften for kjernedannelse og vekst i krystallisering og vil til syvende og sist avgjøre den endelige krystallstørrrelsedistribusjonen.

Measure Crystal Size Distribution

Sondebasert teknologi i prosesser brukes til å spore partikkelstørrelse og formendringer ved full konsentrasjon, uten at det er nødvendig med fortynning eller raffinering. Ved å spore hastigheten og graden av endringer i partikler og krystaller i sanntid, kan de riktige prosessparameterne for krystalliseringsytelse optimeres.

Crystallization Seeding Protocol

Seeding is one of the most critical steps in optimizing crystallization behavior. When designing a seeding strategy, parameters such as: seed size, seed loading (mass), and seed addition temperature must be considered. These parameters are generally optimized based on process kinetics and the desired final particle properties, and must remain consistent during scale-up and technology transfer.

Particle Engineering and Wet Milling

Milling of dry powders can cause significant yield losses and can generate dust, creating health and safety hazards. In response to this, wet milling produces particles with a specifically designed size distribution. It is now common to employ high shear wet milling to break large primary crystals and agglomerates into fine particles.

Anti-Solvent Addition on Supersaturation

In an antisolvent crystallization, the solvent addition rate, addition location and mixing impact local supersaturation in a vessel or pipeline. Scientists and engineers modify crystal size and count by adjusting antisolvent addition protocol and the level of supersaturation.

Temperature Effects Crystallization Size and Shape

Crystallization kinetics are characterized in terms of two dominant processes, nucleation kinetics and growth kinetics, occurring during crystallization from solution. Nucleation kinetics describe the rate of formation of a stable nuclei. Growth kinetics define the rate at which a stable nuclei grows to a macroscopic crystal. Advanced techniques offer temperature control to modify supersaturation and crystal size and shape.

Temperature Effects Crystallization Size and Shape

Changing the scale or mixing conditions in a crystallizer can directly impact the kinetics of the crystallization process and the final crystal size. Heat and mass transfer effects are important to consider for cooling and antisolvent systems respectively, where temperature or concentration gradients can produce inhomogeneity in the prevailing level of supersaturation.

Chemical Process Development & Scale-Up

Design Robust and Sustainable Chemical Processes For Faster Transfer To Pilot Plant and Production

Polymorphism Identification and Control

Polymorphism is a common phenomenon with many crystalline solids in the pharmaceutical and fine chemical industry. Scientists deliberately crystallize a desired polymorph to improve isolation properties, help overcome downstream process challenges, increase bioavailability or to prevent patent conflicts. Identifying polymorphic and morphological transformations in-situ and in real time eliminates unexpected process upset, out of specification product and costly reprocessing of material.

Publikasjoner

Crystallization and Precipitation Engineering Case Studies

White Papers

How to Optimize a Crystallization Step Using Simple Image Analysis
By quickly identifying unnecessary hold times and determining how cooling rate influences crystal growth and nucleation, the cycle time for an interme...
Forstå krystallisering med in situ-mikroskopi
Dynamiske mekanismer, som er nøkkelen til å forstå krystalliseringsprosesser, kan nå observeres med in situ-mikroskopi. En whitepaper forklarer hvorda...
Effective Crystallization Process Development
The quality of a crystallization process greatly influences the quality of the final product. Our new white paper introduces you to the fundamentals o...
Strategies To Control Crystal Size Distribution
This white paper discusses strategies to optimize crystal size distribution during process development and manufacturing.
Improve Industrial Crystallization
Industrial crystallization is an important separation and purification step in the chemical industry. A white paper shows how inline particle technol...
Seeding a Crystallization Process
Seeding is a key step in optimizing a crystallization process, ensuring a consistent filtration rate, yield, polymorphic form and particle size distri...
Scale-up of Batch Crystallization From Lab to Plant
Real-time monitoring of crystallization is shown to provide benefits leading to improved methods for process development, optimization and scale-up. T...
Best Practices For Crystallization Development
This white paper demonstrates the methodology chemists use to optimize critical crystallization parameters such as: Temperature profile Addition rates...
Particle Size Analysis for Process Optimization
This white paper introduces some of the most common particle size analysis approaches and how they can be deployed for the effective delivery of high...

Webinarer

PAT-basert design med kontinuerlig krystallisering
En PAT-aktivert (prosessanalytisk teknologi) designmetodikk som muliggjør rask evaluering av ulike typer kontinuerlig pluggstrøm- og MSMPR-krystallise...
Eliminating Micronization Using Fine Particle Crystallization
Crystal engineering is applied when the crystal size distribution is too large to meet downstream specifications. By designing the crystallization to...
Calibration Free Supersaturation Assessment
The quantitative use of in situ ATR-FTIR for real time supersaturation assessment has been extremely well defined within the literature. However, thes...
metastable zone width (MSZW) crystallization
The webinar focuses on a semi-quantitative method for the optimization and scale-up of hydrodynamically limited anti-solvent crystallization process....
Improving Crystallization and Precipitation
This webinar introduces case studies and highlights best practices used to overcome crystallization and precipitation challenges. The focus will be on...

Bruksmerknader

In-Process Characterization of Antisolvent Crystallization
Ensure fast and efficient scale-up by optimizing crystallization early in development. Target particle size specifications to speed up downstream proc...
Polymorph and Pseudo-polymorph Transition in-process monitoring of habit change
Improve purity by ensuring total polymorphic form conversion. Enhance process robustness by monitoring crystallization processes in real time. Charact...

Relaterte produkter

Technology for Crystallization Development and Scale-up

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