Simple, Versatile and Secure Pipetting
1. When was the electronic pipette invented?
Electronic Pipettes are handheld instruments commonly used in academic, biotech, pharmaceutical and other labs to transfer precise amounts of liquid from one container to another. Pipettes range from very basic graduated glass tubes to sophisticated precision instruments capable of aspirating and dispensing liquid in increments as small as a fraction of a microliter. The most common pipette used in life science labs around the world is the single-channel air displacement pipette.
![]() | ![]() | ![]() | ![]() |
Single Channel Electronic Pipette | Electronic Multichannel Pipette | Electronic Adjustable Spacer Multichannel Pipette E4 XLS | Pipetting Accessories |
With the Rainin E4 XLS+ Single Channel Electronic Pipette, METTLER TOLEDO has set the standard for simplicity and performance in electronic pipetting. | Multi-dispense, mixing and other pipetting modes on the E4 XLS+ multichannel pipette are easy to use and minimize setup time for high throughput work. | Reduce up to 98% of your pipetting steps when transferring multiple samples between plates, tubes and other vessels. | Protect your high-performance pipettes with original Rainin parts and accessories. |
Fast navigation Quick, easy controls simplify E4 XLS+ operation. The App Master Versatile range of pipetting modes for any task. Save your Protocols! Save time-store your favorite protocols. Secure GLP/GMP functionality Secure service data, lockable modes, and password. Highly Configurable Configure your pipette for simplicity and security. | Superior channel-to-channel consistency New seals and LTS tips give channel consistency. Simplify repetitive microplate pipetting Multi-dispense and AutoPace do the work for you. Lightweight Lightweight, yet balanced and robust. Lightest Touch LTS tips reduce tip eject forces up to 80%. FPLC in a Tip! PureSpeed funtionality is installed in all E4 XLS+. | Move samples from tubes to plates in no time Easy channel spacing changes for any vessel format. Simplify repetitive microplate pipetting Multi-dispense and AutoPace do the work for you. Fast navigation Quick, easy controls simplify E4 XLS operation. High Performance Designed for years of accuracy and durability. | Wall power supply Charge your E4 XLS while you work. Filters Prevent liquids and aerosols entering the shaft. Reservoirs Sterile polypropylene reagent reservoirs. |
With the Rainin E4 XLS+ Single Channel Electronic Pipette, METTLER TOLEDO has set the standard for simplicity and performance in electronic pipetting.
Multi-dispense, mixing and other pipetting modes on the E4 XLS+ multichannel pipette are easy to use and minimize setup time for high throughput work.
Reduce up to 98% of your pipetting steps when transferring multiple samples between plates, tubes and other vessels.
Protect your high-performance pipettes with original Rainin parts and accessories.
Services

Expert Service – Tailored to Fit Your Pipetting Needs
METTLER TOLEDO supports and services your pipettes through their entire life-cycle, from good pipetting techniques to preventive maintenance and calibration to equipment repair.

Order Pipette Service & Calibration
Support & Repair

Training & Consulting

Publications

Rainin Documentation Center

The Ergonomics of Pipetting

Pipetting Calibration and Technique

Rainin Product Catalog
Superior Products for Peak Performance
For detailed information on Rainin pipettes, tips, specialty products and service offering. Order a free catalog or download a copy online. It features background information on pipetting mechanics, manufacturing and selection.Pipette Tip Finder
Find Rainin BioClean tips for all major pipette brands
Tutorials
E4 XLS, XLS+ pipette: Basic Mode
In Basic, you can:
- Aspirate & dispense a volume
- Control aspiration & dispense speed
Sections in this video:
- Set a Volume
- Set Speed
- View Quick Help
- Aspirate and Dispense
- Turn Off the Pipette
E4 XLS, XLS+ pipette: Manual Mode
In Manual, you can:
- Measure the volume of a sample
- Start or stop aspiration or dispense from any point
- Actuate volume in tiny, precise, motor-controlled steps
Sections in this video:
- Basic Manual Pipetting
- Aspirate or Dispense in Micro Steps
- Measure a Volume
- Set and Use Fixed Volumes
- Use the Cycle Counter
E4 XLS, XLS+ pipette: Multi-Dispense
Using Multi-Dispense, you can:
- Dispense a series of equal or unequal volumes from just one aspiration;
- Fill plates faster, especially with a multichannel pipette;
- And you can reduce hand strain by using timed dispense
Sections in this video:
- Basic Multi-Dispense
- Use and Save a Fixed Volume
- Dispense a Series of Unequal Volumes
- Automatic Dispense with Auto Pace
- Joystick Blowout On / Off
E4 XLS, XLS+ pipette: Advanced Mode
In Advanced Mode, you can:
- Mix automatically
- Track your work with the cycle counter
- Dispense different volumes sequentially
- Turn Blowout On or Off
Sections in this video:
- Adjust aspirate & dispense speeds
- Use and save fixed volumes
- Dispense stored volumes sequentially
- Mix
- Turn Blowout On or Off
- Use the cycle counter