Biotech and Hygienic Processes

Pharmaceutical waters are a multi-functional resource, crossing all disciplines in the pharmaceutical industry. Water is used as a raw material, solvent, ingredient, reagent, and cleaning agent, and is produced in a variety of “pure” forms. The wide variety of pharmaceutical waters and water systems means their production is becoming an increasingly specialized process that requires highly dependable instrumentation. For continuous assurance of water quality, on-line measurement of TOC, ORP and conductivity is essential.

Media is used in biopharmaceutical operations to promote bacteria growth. Growth conditions are heavily dependent on pH, and by properly adjusting pH in the media, cost savings can be achieved through decreased acid/alkaline dosage during inoculum and production fermentations.

Separation processes are critical steps in the production of biological products, as they directly affect product consistency and yield. Separating the cells is generally carried out by centrifugation or filtration. Controlling separation by turbidity based on loading, leads to greater efficiency and productivity from the filtration process.

Chromatography plays an important role in the purification of pharmaceutical products derived from biotechnology processes. It isolates and purifies the product of interest. Maintaining precise pH and conductivity levels is critical in liquid chromatography.