The webinar focuses on a semi-quantitative method for the optimization and scale-up of hydrodynamically limited anti-solvent crystallization process. This protocol combines in situ Process Analytical Technologies (PAT) with Computational Fluid Dynamics (CFD) to facilitate the production of a knowledge based scale-up strategy for this mixing limited crystallization process. A "scale-up toolbox" is used to optimize bench scale crystallizations to produce efficient, repeatable crystallizations.
Certain attributes of turbulent mixing have been identified to impact key crystallization characteristics, including:
Group CEO & Co-Founder, APC & VLE Therapeutics
Mark Barrett received his Ph.D. in Chemical Engineering from University College Dublin (UCD). His thesis work focused on crystallization development and scale-up. Prior to co-founding APC in 2011, Mark worked for Solid State Pharmaceutical Cluster (SSPC) and Schering Plough.