Online LC-MS to Investigate Mechanisms of Impurity Formation
What Happens at the End of Your Reactions
Programöversikt
- How DirectInject-LC can be used to monitor the formation of impurities throughout chemical reactions in order to maximize yield and purity.
- How data dense LC-MS data enables the understanding of complex catalytic systems.
- How combining PAT tools with DirectInject-LC can be used to understand difficult to study electrochemistry processes.
This presentation highlights how DirectInject-LC is a powerful tool for studying various types of reactions. From small molecule synthetic reactions to complex bioconjugations, understanding reactions through data-dense, species-specific quantitative analysis can help scientists optimize manufacturing processes. Maximizing yield and purity is a primary focus. Two examples clearly demonstrate the unique value of DirectInject-LC in understanding Buchwald-Hartwig amination and electrochemical reactions. In both examples, LC-MS identification and monitoring provides a direct handle to minimize impurities in the final product by elucidating the mechanisms of impurity formation.
Designed for analytical chemists working in R&D settings (pharmaceutical and chemical industries) and synthetic organic chemists interested in reaction mechanism (industry and academic).
About the Presenter
Kenji Kurita
Synthetic Molecule Pharmaceutical Sciences, Genentech
Kenji Kurita leads a small group of Analytical Chemists at Genentech called the Process Analytical Group. Their role is to support process chemistry by performing routine measurements to help study their reactions. The team has a laser focus on purity and yield to maximize their impact on cost of goods.
