DSC of Human Stratum Corneum

The passage of drugs through the skin barrier, the human stratum corneum (HSC), is often too slow for local, regional or systemic therapeutical purposes. One way to accelerate the penetration would be through the ointment excipients (vehicle) or through additional penetration accelerator in the HSC. This article shows that DSC measurement of isolated HSC is an effective method to detect specific interactions of vehicles or added penetration accelerators with components of HSC and to investigate the mechanism involved. The comparison of the effectiveness of different substances as penetration accelerators is possible.

^{DSC of human stratum corneum | Thermal Analysis Application No. UC 96 | Application published in METTLER TOLEDO Thermal Analysis UserCom 9}