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What are the United States Pharmacopeia (USP) requirements for USP reference substances?

USP specifies that the measured melting range must

a) Lie within the specified minimum and maximum temperatures (e.g. 81–83 °C for vanillin), and
b) Not be broader than the specified admissible values (e.g. 1.5 °C for vanillin).

So, the permitted measured melting range for vanillin could be 81.0–82.5, 81.3–82.8 °C etc.

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