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As a reaction is scaled from lab to plant, scalability problems may suddenly emerge for various reasons. The causes of thermal incidents are often attributed to:
Incidents can be avoided by determining the relevant data at laboratory scale. Laboratory work is performed under process-like conditions using reaction calorimeters, so that the results can be directly applied to larger-scale operations.
Reaction calorimetry provides a high level of process understanding, so that the necessary procedures can be performed routinely, robustly and to the required standard of quality.
Understand the Risks - Safe Chemical Processes at Scale
When developing manufacturing processes, information about the process, the toxicity and stability of raw materials, intermediates and final product is important. Scientists use this data to establish the ideal reaction procedure and to gain an indepth understanding of the process itself. The Guide to Process Safety discusses the key challenges to consider when designing a safe.
We support and service your measurement equipment through its entire life-cycle, from installation to preventive maintenance and calibration to equipment repair.
Reaction calorimetry measures the heat released from a chemical reaction or physical process under process-like conditions and provides the fundamentals of the thermochemistry and kinetics of a reaction.
Calorimetric information is crucial when determining how chemical reactions can be transferred safely from lab to plant. Along with the chemical development workflow, reaction calorimetry provides the information needed for each of the individual steps and is subsequently converted into information to evaluate the risk, scalability and criticality of a process. Reaction calorimetry helps to identify issues related to heat and mass transfer or mixing, and allows the determination of the correct temperature, stirring or dosing profile online. Reaction calorimetry also uncovers unexpected behavior and makes other scalability issues visible and quantifiable.
Calorimetry heat flow screening in a 100ml reaction vessel provides information not found in temperature measurements alone. Data from an exothermic oxidation reaction indicates that reactor temperature (Tr) measurements are not accurate indicators of reaction heat. The reactor temperature minus the jacket temperature (Tr-Tj) underestimates energy release and associated safety consequences. The reaction heat profile (Qr) from heat flow calorimetry tracks the quantitative heat release and is the best indication of future problems even before scaling to a 1 liter.