Real-Time Microscopy for Crystals, Particles, Droplets | ParticleView
Real-Time Microscopy

Real-Time Microscopy for Crystals, Particles and Droplets

ParticleView with PVM Technology

 

Solve Difficult Particle Problems Using Image-Based Evidence

Common real-time microscopy applications include:

  • Control Crystal Size and Shape Distribution
  • Using Solubility and Me...

Common real-time microscopy applications include:


Since acquiring Lasentec in 2001, METTLER TOLEDO has continued to advance the development of ParticleTrack with FBRM and ParticleView with PVM technologies. With thousands of installations worldwide from the R&D laboratory to the manufacturing plant, our probe-based technologies are acknowledged as the gold standard for measuring and visualizing the rate and degree of change in particle and droplet systems as they naturally exist in process.


 

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Products and Specs

Particle Vision and Measurement (PVM) Models

 
Products and Specs
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Probe Wetted Material
Probe Window Material
Probe Wetted Temperature Range
Probe Wetted Pressure Range
Certifications
Material No.: 14000031
See details
Probe Wetted MaterialC22 alloy
Probe Window MaterialSapphire
Probe Wetted Temperature Range-80°C to 120°C (purged); 10°C to 120°C (standard)
Probe Wetted Pressure Range0 barg to 10 barg (standard); up to 100 barg (custom)
CertificationsIEC/UL/CSA 61010-1; EN 61326-1; Class 1 Laser Device compliant with 21CFR1040.10, 21CFR1040.11 and IEC 60825; Probe back end rated for IP65 and 4X
For Use InLaboratory: EasyMax, OptiMax or Larger
SoftwareiC PVM
Imaging SystemFront Lasers: Backscattered images; Back Lasers: Transmission images with use of optional clamp-on reflector
IlluminationInternal light source; Front Lasers: 4; Back Lasers: 4
Probe Window SealsTM (standard, no o-rings)
Probe Diameter19 mm [0.75 in]
Probe Wetted Length400 mm [15.75 in]
Conduit Length2 m [6.6 ft]
Field of View1300 μm x 890 μm
Optical Resolution> 2 μm
Image Resolution1500 x 1024 pixels
Weight (probe, interface unit and cables)1.45 kg [3.20 lb]
Air RequirementsAlways use clean, dry instrument quality air or Nitrogen; Low flow purge (optional, use to avoid condensation), 1.4 barg [20 psig], 0.5 SLPM [0.02 SCFM]
Power RequirementsPowered USB extender; 100-240V (auto-switching), 50/60Hz, 0.3A
Comparison

Documentation

Documentation for Probe-Based Real Time Microscopy

Datasheets

ParticleView V19 With PVM Technology
Visualize particles and particle mechanisms in real time to study particle size and shape
iC PVM Software
View particles in real time to study particle size, shape and concentration with iC PVM

White Papers

7 Crystallization Mechanisms
This guide describes seven hidden mechanisms that can influence your crystallization process and outlines strategies to control them.
Crystallization in Process Chemistry
This white paper discusses how to apply simple PAT tools to crystallization in process chemistry.
How to Optimize a Crystallization Step Using Simple Image Analysis
By quickly identifying unnecessary hold times and determining how cooling rate influences crystal growth and nucleation, the cycle time for an interme...
Particle Size Analysis for Process Optimization
This white paper introduces some of the most common particle size analysis approaches and how they can be deployed for the effective delivery of high...

Applications

Crystallization and Precipitation
Optimization and scale-up of crystallization and precipitation to produce a product that consistently meets purity, yield, form and particle size spec...
Optimization and Scale-up of Batch Crystallization
A well-designed batch crystallization process is one that can be scaled successfully to production scale - giving the desired crystal size distributio...
Solubility and Metastable Zone Width (mzw) Determination
Solubility curves are commonly used to illustrate the relationship between solubility, temperature, and solvent type. By plotting temperature vs. solu...
Crystal Nucleation and Growth
Scientists and engineers gain control of crystallization processes by carefully adjusting the level of supersaturation during the process. Supersatur...
Measure Crystal Size Distribution
In-process probe-based technologies are applied to track particle size and shape changes at full concentration with no dilution or extraction necessar...
Crystallization Seeding Protocol
Seeding is one of the most critical steps in optimizing crystallization behavior. When designing a seeding strategy, parameters such as: seed size, se...
Anti-Solvent Addition on Supersaturation
In an antisolvent crystallization, the solvent addition rate, addition location and mixing impact local supersaturation in a vessel or pipeline. Scien...
Temperature Effects Crystallization Size and Shape
Crystallization kinetics are characterized in terms of two dominant processes, nucleation kinetics and growth kinetics, occurring during crystallizati...
Process Analytical Technology (PAT)
Process Analytical Technology (PAT) is changing the way R&D, scale-up, and manufacturing are performed. PAT transforms productivity, improves safety,...
Flow Assurance in Oil and Gas Production
Flow assurance deals with a cost-effective approach to produce and transport fluids from the reservoir to a processing facility. Flow assurance challe...

Related Products and Solutions

METTLER TOLEDO Lasentec FBRM
Probe-based instrument inserted directly into a process to study how particle size and count change over time with Focused Beam Reflectance Measuremen...
chemical synthesis reactors
Chemical synthesis reactors increase productivity in the lab
FTIR Spectroscopy with In Situ Reaction Monitoring
Fourier Transform Infrared (FTIR) Spectroscopy For Real-Time Monitoring Of Chemical Reactions

Software

iC PVM particle characterization software
Acquire and share process knowledge by viewing particles in real time to understand particle size, shape and concentration with iC PVM Software.
iC Data Center
Capture, Prepare, Share Experimental Data

Citations

Crystallization and Precipitation Citation List
Crystallization and precipitation citation list and publications

On-Demand Webinars

Traditional Offline Microscopy
This presentation discusses how to use real time microscopy for particles, crystals and droplets to develop high quality processes in less time and at...
Crystallization Image Analysis
This presentation describes the role of image analysis in crystallization monitoring.
Liquid-Liquid Phase Separation
This presentation describes a strategy employed to design and develop robust, scalable crystallization processes that avoids Liquid-Liquid Phase Separ...
Agglomeration & Crystallization Using Particle Measurement
This presentation details how using data from in situ particle vision and measurement tools can be used to determine particle size and shape trends re...

V19 Hardware Support

Positioning a ParticleTrack or ParticleView Probe
ParticleTrack probes use Focused Beam Reflectance Measurement (FBRM) technology to track the rate and degree of change to particles and particle struc...
Using the Purge Controller for ParticleTrack G400 or ParticleView V19
The Purge Controller is an optional accessory that can be purchased for use with ParticleTrack G400 and ParticleView V19. Purging is required where...
ParticleView V19 Hardware Manual
This manual covers specific safety and quality information relating to the ParticleView V19 with PVM (Particle Vision Measurement) technology. The P...
ParticleView V19 Safety Manual
This safety manual supplements the ParticleView V19 with PVM Technology Hardware Manual.
ParticleTrack & ParticleView Onsite Training
Training and familiarization with ParticleTrack with FBRM technology and ParticleView with PVM technology will ensure that all users can walk up to in...

Software Support

iC PVM Software Quick Start Guide
This guide introduces a new user to the iC PVM software graphical user interface (GUI) and describes several choices for getting started. Create and r...
iC PVM Software User Install Guide
iC PVM installation is wizard-guided. This guide includes detailed installation steps along with implementation information for the iC PVM administra...
ParticleTrack & ParticleView Onsite Training
Training and familiarization with ParticleTrack with FBRM technology and ParticleView with PVM technology will ensure that all users can walk up to in...
iC PVM particle characterization software
Acquire and share process knowledge by viewing particles in real time to understand particle size, shape and concentration with iC PVM Software.

Services

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