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Quantifying Dissolution & Disintegration
Quantifying tablet disintegration profiles in situ and in real time enables scientists to reliably understand the breakage and dispersion mechanisms that govern Active Pharmaceutical Ingredient (API) release rates. This essential process knowledge can support the prediction of in vivo drug release profiles during formulation development, and can help identify the root cause of inconsistencies during release testing.
The resulting mechanistic information complements traditional offline dissolution testing methods, and can support the development and release of bioavailable, stable, and manufacturable dosage forms.
ParticleTrack with FBRM technology continuously monitors changes in particle size and count as capsules an tablets disintegrate and dissolve. The resulting mechanistic information complements traditional offline dissolution testing methods and can support the development and release of bioavailable, stable and manufacturable dosage forms.
ParticleTrack applications include:
Choose Optimized Process Parameters
Emulsion droplet size and stability are critical parameters to consider during the development of a topical or micro-encapsulated product. Characterizing droplet size effectively allows scientists to solve process bottlenecks and improve product quality. Traditionally, scientists have relied on offline particle size analyzers to perform emulsion and suspension characterization. Offline analysis typically requires sample preparation and sample dilution prior to analysis which, in the case of emulsions, can significantly change the droplet size in an emulsion sample within the time required for preparation and analysis.
The emergence of Process Analytical Technologies (PAT) allows scientists and engineers to track the rate and degree of change in droplet systems as they naturally exists in process without the need for sampling or sample preparation: