Implementation of Continuous Crystallization to Circumvent Metastable Liquid-Liquid Separation - METTLER TOLEDO
 
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On Demand Webinar

Implementation of Continuous Crystallization to Circumvent Metastable Liquid-Liquid Separation

On Demand Webinar

High concentrations of an organic solute may lead to metastable liquid-liquid separations due to solvent-solute interactions, even in otherwise miscible solvent systems. The formation of such non-ideal phases is undesirable in crystallization operations. Potential side effects of this phenomenon are uncontrolled nucleation and growth, inadequate impurity purge, solvent entrainment in the product, and morphological inconsistencies in the solids. Despite the inherent challenges that arise due to the formation of non-ideal phases, they have become increasingly common in pharmaceutical process development due to the current shift in the industry towards higher-complexity molecular structures. The growing prevalence of these complex systems prompted the implementation of novel development tools that can assist process engineers in creating robust crystallization procedures.

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Carlos Pons Siepermann - Bristol-Myers Squibb
26 Minutes
English
Carlos Pons Siepermann - Bristol-Myers Squibb
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