Monitoring and Detection of Byproduct Crystallization - METTLER TOLEDO
 
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Monitoring and Detection of Byproduct Crystallization

On Demand Webinar

Reactive Crystallization of Beta-Lactam Antibiotics

Monitoring and Detection of Byproduct Crystallization
Monitoring and Detection of Byproduct Crystallization

In-situ monitoring of solid-phase composition during crystallization is often accomplished by Raman spectroscopy, but not all compounds in a system of interest are strongly Raman active. Researchers at Georgia Tech developed an image-based analysis to detect a second undesired solid phase with EasyViewer - before other PAT tools detect the appearance of the solid.  Matthew McDonald describes the system, which involves the reactive crystallization of beta-lactam antibiotics, wherein a byproduct of the enzyme-catalyzed reaction can crystallize within the antibiotic slurry.

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Matthew A. McDonald - Georgia Institute of Technology
35 Minutes
English
Matthew McDonald - Georgia Tech
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