Thermal analysis of pharmaceuticals
Thermal Analysis is often used to investigate pharmaceutical substances. Polymorphism, pseudo-polymorphism, phase diagrams, stability, and purity determination can all be measured by thermal analysis.
Thermal Analysis Techniques
The four main techniques of thermal analysis, DSC, TGA, TMA, and DMA are ideal for characterizing such substances. The chief advantage is that properties can be measured as a function of the temperature or time over a wide temperature range, from –150 to 1600 °C.
In this webinar, we will show how thermal analysis is used to investigate pharmaceutical substances. We will present some typical examples measured by DSC, TGA, TMA or DMA.
Thu Apr 29 2021 14:00 +0000 [ English ]
Important Effects and Properties Measured by Thermal Analysis
- The most important effects that can be analyzed by DSC are the melting point, melting range and melting behavior.
- DSC is also used to determine the heat of fusion, purity, polymorphism, the glass transition, and oxidation stability.
- The main applications of TGA are evaporation, desorption and vaporization behavior, thermal stability, decomposition kinetics, and the analysis of composition.
- TOA or thermo-optical analysis is used to study the melting point, melting range and polymorphism using visual observation and video recording.
- MP indicates the automatic detection of the melting point or melting range.
- TMA is normally used to study the expansion or shrinkage of materials and the glass transition.
- DMA is the most sensitive method for characterizing the glass transition of materials.