By quantifying tablet disintegration, ParticleTrack with FBRM technology provides valuable insight for formulation development. The ability to monitor tablet and granule disintegration behavior allows for an understanding of the underlying mechanisms of product performance. All of these dynamic events can be monitored in-situ with ParticleTrack. Measurement for optimization in real time – ParticleTrack is a precise and sensitive technology which tracks changes to particle dimension, particle shape, and particle count. Over a wide detection range from 0.5 µm to 2000 µm, measurements are acquired in real time, while particles are forming and can still be modified, enabling process optimization and control. With ParticleTrack, no sampling or sample preparation is required – even in highly concentrated (70 % and higher) and opaque suspensions.
"We find ParticleTrack can elucidate the kinetics and mechanisms of tablet, granule, and particle disagglomeration in dosage forms, and is a more sensitive physical characterization method than compendial USP dissolution" Mark Menning - Nucleo Life Sciences
"ParticleTrack technology, where applied appropriately, can facilitate improved optimization of drug product formulation and process parameters, bridging of in vitro to human bioavailability performance, and elucidate complex physical stability changes" Sean Dalziel - Cleo Life Sciences