Measuring Polymerization Reactions | Polymer Chemistry

Polymerization Reactions

Comprehensive Understanding of Kinetics to Develop Synthetic Polymer Chemistry


What Are Polymerization Reactions?
Polymerization Reaction Understanding
ABC Triblock Copolymer Case Study
ReactIR Ready
Kinetics of Tetrahydrofuran Polymerization Reaction

Reactors for Polymerization Reactions

Applicazioni

Applications Related to Polymerization Reactions

Chemical Reaction Kinetics Studies
Study Chemical Reaction Rates and Measure Kinetics Inline

In situ chemical reaction kinetics studies provide an improved understanding of reaction mechanism and pathway by providing concentration dependences of reacting components in real-time. Continuous data over the course of a reaction allows for the calculation of rate laws with fewer experiments due to the comprehensive nature of the data.  Reaction Progression Kinetics Analysis (RPKA) uses in situ data under synthetically relevant concentrations and captures information throughout the whole experiment ensuring that the complete reaction behavior can be accurately described.

Chemical Process Development & Scale-Up
Design Robust and Sustainable Chemical Processes For Faster Transfer To Pilot Plant and Production

Design Robust and Sustainable Chemical Processes For Faster Transfer To Pilot Plant and Production

Heat Transfer and Process Scale-up
How Heat Transport in Agitated Vessels Affects Process Scale-up

Scaling-up a chemical process from lab to manufacturing gives useful results only with accurate heat transfer coefficients. Measuring the jacket and reactor temperature (during the release of a well-defined amount of heat) allows researchers to accurately compute the thermal resistance which is used to model the heat transfer and make critical predictions for reactors at larger scale. Reaction calorimetry is essential to determine parameters that impact the heat transfer and the heat transfer coefficients to develop models to maximize the bandwidth of a manufacturing plant. 

Trasferimento di massa e velocità di reazione
Miscelazione in un reattore chimico ed effetto sulla chemiocinetica e lo scale-up

La miscelazione consiste nel ridurre o eliminare l'eterogeneità delle fasi, che possono essere miscibili o immiscibili. Per effettuare lo scale-up e ottimizzare i processi, è necessario quantificare l'effetto della miscelazione sulla velocità di reazione. Esperimenti automatizzati e controllati, effettuati in parallelo in un sistema di reattori da laboratorio, consentono di stabilire una correlazione tra i diversi valori di trasferimento di massa, in modo da regolare rapidamente l'area di interfaccia gas/liquido e il volume del reattore. Si ottengono così le condizioni desiderate necessarie per lo scale-up o lo scale-down di un processo.

Chimica a flusso continuo
Ridurre la durata del ciclo e migliorare la sicurezza, la qualità e il rendimento

La chimica a flusso consente di realizzare fasi esotermiche di sintesi altrimenti impossibili con i reattori discontinui. Inoltre, i miglioramenti nella progettazione dei reattori continui moltiplicano le possibilità di reazione, cosa che risulta limitata nei reattori discontinui. Ciò si traduce spesso in una migliore qualità del prodotto e in un rendimento più elevato.  Associata alla Process Analytical Technology (PAT), la chimica a flusso consente di eseguire rapidamente analisi, ottimizzazione e scale-up delle reazioni chimiche.

Chemical Process Safety
Determine the Safety of Chemical Processes Prior to Scale-up

How can I be sure that my chemical process is safe? It is critical to understand the risks inherent in moving a chemical process to a larger scale before manufacturing begins. The use of reaction calorimetry is an essential part of process development studies, providing detailed information about the rate of heat production. This allows researchers to optimize the temperature and dosing profiles to maximize process safety at all times, and reduce to a minimum the risks involved.

Process Analytical Technology (PAT)
PAT is Changing Chemical Process Development, Scale-up, and Manufacturing

Process Analytical Technology (PAT) is changing the way R&D, scale-up, and manufacturing are performed. PAT transforms productivity, improves safety, and provides measurements for rapid troubleshooting. Process Analytical Technology (PAT) applications range from monitoring chemical reactions, crystallization, formulations, and bioprocessing.

Control Residual Isocyanate
Process Analytical Technology for Continuous Measurement of NCO

Isocyanates are critical building blocks for high performance polyurethane-based polymers that make up coatings, foams, adhesives, elastomers, and insulation. Concerns over exposure to residual isocyanates led to new limits for residual isocyanates in new products. Traditional analytical methods for measuring the residual isocyanate (NCO) concentration using offline sampling and analysis raise concerns. In situ monitoring with process analytical technology addresses these challenges and enables manufacturers and formulators to ensure that product quality specifications, personnel safety, and environmental regulations are met.

Chemical Reaction Kinetics Studies

In situ chemical reaction kinetics studies provide an improved understanding of reaction mechanism and pathway by providing concentration dependences of reacting components in real-time. Continuous data over the course of a reaction allows for the calculation of rate laws with fewer experiments due to the comprehensive nature of the data.  Reaction Progression Kinetics Analysis (RPKA) uses in situ data under synthetically relevant concentrations and captures information throughout the whole experiment ensuring that the complete reaction behavior can be accurately described.

Chemical Process Development & Scale-Up

Design Robust and Sustainable Chemical Processes For Faster Transfer To Pilot Plant and Production

Heat Transfer and Process Scale-up

Scaling-up a chemical process from lab to manufacturing gives useful results only with accurate heat transfer coefficients. Measuring the jacket and reactor temperature (during the release of a well-defined amount of heat) allows researchers to accurately compute the thermal resistance which is used to model the heat transfer and make critical predictions for reactors at larger scale. Reaction calorimetry is essential to determine parameters that impact the heat transfer and the heat transfer coefficients to develop models to maximize the bandwidth of a manufacturing plant. 

Trasferimento di massa e velocità di reazione

La miscelazione consiste nel ridurre o eliminare l'eterogeneità delle fasi, che possono essere miscibili o immiscibili. Per effettuare lo scale-up e ottimizzare i processi, è necessario quantificare l'effetto della miscelazione sulla velocità di reazione. Esperimenti automatizzati e controllati, effettuati in parallelo in un sistema di reattori da laboratorio, consentono di stabilire una correlazione tra i diversi valori di trasferimento di massa, in modo da regolare rapidamente l'area di interfaccia gas/liquido e il volume del reattore. Si ottengono così le condizioni desiderate necessarie per lo scale-up o lo scale-down di un processo.

Chimica a flusso continuo

La chimica a flusso consente di realizzare fasi esotermiche di sintesi altrimenti impossibili con i reattori discontinui. Inoltre, i miglioramenti nella progettazione dei reattori continui moltiplicano le possibilità di reazione, cosa che risulta limitata nei reattori discontinui. Ciò si traduce spesso in una migliore qualità del prodotto e in un rendimento più elevato.  Associata alla Process Analytical Technology (PAT), la chimica a flusso consente di eseguire rapidamente analisi, ottimizzazione e scale-up delle reazioni chimiche.

Chemical Process Safety

How can I be sure that my chemical process is safe? It is critical to understand the risks inherent in moving a chemical process to a larger scale before manufacturing begins. The use of reaction calorimetry is an essential part of process development studies, providing detailed information about the rate of heat production. This allows researchers to optimize the temperature and dosing profiles to maximize process safety at all times, and reduce to a minimum the risks involved.

Process Analytical Technology (PAT)

Process Analytical Technology (PAT) is changing the way R&D, scale-up, and manufacturing are performed. PAT transforms productivity, improves safety, and provides measurements for rapid troubleshooting. Process Analytical Technology (PAT) applications range from monitoring chemical reactions, crystallization, formulations, and bioprocessing.

Control Residual Isocyanate

Isocyanates are critical building blocks for high performance polyurethane-based polymers that make up coatings, foams, adhesives, elastomers, and insulation. Concerns over exposure to residual isocyanates led to new limits for residual isocyanates in new products. Traditional analytical methods for measuring the residual isocyanate (NCO) concentration using offline sampling and analysis raise concerns. In situ monitoring with process analytical technology addresses these challenges and enables manufacturers and formulators to ensure that product quality specifications, personnel safety, and environmental regulations are met.

Pubblicazioni

Publications Related to Polymerization Reactions

On-Demand Webinars

Professor Robson Storey - University of Southern Mississippi
Real-time in situ mid-infrared monitoring of polymerization reactions involving isobutylene and styrene is the focus of this presentation. Professor R...
Polymerization Process Monitoring
This presentation discusses polymerization process monitoring and how the value of real-time in situ Fourier Transform Infrared (FTIR) spectroscopy co...
Emulsions and Polymerization
In the chemical industry, the polymerization and final particle distribution are affected by the initial emulsion droplet size of the monomer. This we...
Calorimetria di reazione nell'industria chimica
Questo seminario on-line si incentra sulle applicazioni e sull'importanza della miscelazione e della calorimetria di reazione nel settore della chimic...

Value Content

Minimizzare i residui di isocianato nel poliuretano
Gli isocianati influenzano le prestazioni dei polimeri nel poliuretano utilizzato in rivestimenti, schiume, adesivi, ecc. Il monitoraggio in linea gra...
Mechanistic Insights to Reactions
Two recently published chemical reaction kinetics studies examples are introduced from researchers at Bristol-Myers Squibb, Scripps, and University of...
Scambio termico in recipienti agitati
Nel settore farmaceutico e chimico i processi in batch e semi-batch sono i più comuni in produzione, scale-up e sviluppo. Lo scale-up di un processo...
Monitoraggio delle reazioni chimiche in situ
“Come fare di più in poco tempo?” è un argomento costante nei laboratori di sviluppo chimici visto che i ricercatori devono consegnare i prodotti chim...
Analisi dimensionale delle particelle per l'ottimizzazione dei processi
In questo libro bianco vengono presentati alcuni approcci relativi alla caratterizzazione in linea delle particelle e viene spiegato come tali approcc...
Progettazione efficace degli esperimenti
La progettazione degli esperimenti (Design of Experiments, DoE) fornisce un'alternativa all'esame individuale di ciascun parametro delle reazioni offr...

Prodotti correlati

Products for Measuring Polymerization Reactions

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