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Home Hệ Phản ứng Hóa học Tự động Scale‑up Suite

Scale‑up Suite

Chemical Process Modeling Software for Scientists and Engineers

Scale-up Suite™ is a leading supplier of process development software for the global pharmaceutical and chemical industries. Our software provides models for all common unit operations, from reaction kinetics to product isolation, and across both lab and plant scales. This enables rapid development, optimal processes, and robust scale-up.

Scale-up Suite, including Dynochem®, Reaction Lab™, and Dynochem Biologics Lab™, offers a comprehensive software package for everyday calculations and process simulations. It includes extensive material property information, user-friendly applications for everyday tasks, ready-to-use template models, and a flexible platform for customizing dynamic systems. Backed by our outstanding user support and training, Scale-up Suite empowers companies to gain deep process knowledge and achieve successful manufacturing of their products.

See how Scale-up Suite can benefit your company. Contact us today!

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scale-up suite software
See how Scale-up Suite can benefit your company. Contact us today!
reaction lab software thumbnail

Intelligently Design Reactions

Optimize reactions faster, using fewer experiments

  • Use mechanistic models to predict conditions that maximize yield and minimize impurities in synthetic organic processes
  • Quickly transform routinely collected process, PAT, and offline analytical data into kinetic models that enable greater reaction understanding with limited time and materials
  • Extract full value from data to provide critical guidance and speed development work
  • Gain insight into reaction mechanisms for deep reaction understanding that can be leveraged for optimal processing 
  • Build confidence in scale-up using data-driven, prediction-based methodologies
  • Develop higher-performing, greener chemistry to contribute to sustainability goals

Learn more about Reaction Lab.

dynochem scale-up

Right First Time Scale-Up

Predict the performance of every unit operation before each campaign to ensure success on scale-up from lab to plant.

  • Predict mixing effects on reactions and crystallizations at different scales and vessel types
  • Simplify and accelerate tech transfer and increase collaboration with manufacturing partners
  • Design safe processes by predicting key parameters such as time to maximum rate (TMR) and maximum temperature of synthesis reaction (MTSR)
  • Develop dynamic models for common chemical unit operations, such as reactions, solvent exchange distillation, extractions, filtrations, and drying, to gain process knowledge and enable effective scale-up and tech transfers
  • Access an extensive database of material properties for common solvents and chemicals
  • Quickly perform routine calculations through easy-to-use applications such as chemical equilibrium, mixing and heat transfer, process fit, and solubility prediction
  • Extensive library of ready-to-use simulation tools developed by industry experts, readily available to all users

Learn more about Dynochem.

bioprocess scale-up

Bioprocess Modeling at Any Scale

Enable process characterization across typical upstream and downstream unit operations

  • Mixing calculation tools help scale from lab reactors such as Ambr® 15, shake flasks, vials, and rocked/wave bags to stirred tank reactors
  • Ensure adequate mixing without excessive shear in operations ranging from media development/prep to UF/DF, avoiding batch failures and yield loss
  • Develop bioreactor models to support the prediction of glucose and DO levels, pH, and titer at each scale, leveraging mixing tools to ensure uniform spatial distribution
  • Downstream capabilities include models for disk-stack centrifugation, depth filtration, chromatography, virus inactivation, conjugation, tangential flow filtration (TFF), and diafiltration, including the design of mixing set-ups
  • Fill/finish tools leverage predictions of lyophilization (primary and secondary drying) in vials, including prevention of meltback/collapse, and ensure adequate mixing of excipients

Learn more about Dynochem Biologics.

Case Studies from Industry

Data-Driven Reaction Models in Late-Stage Pharmaceutical Process Development
How Reaction Lab Can Compensate for a Weaker Background in Reaction Kinetics
PAT and Model-Based Approach to Accelerate Biopharma Process Development
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Sustainable Development with Scale-up Suite

METTLER TOLEDO is committed to not only maintaining carbon neutrality for our operations but also to establishing science-based targets to drive an absolute reduction of greenhouse gas emissions across our operations and supply chain. Scale-up Suite enables you to design processes that use less raw materials, generate less waste, and require less energy for a more efficient, high-performing process.

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GreenMT framework

Is Scale-up Systems the same company as METTLER TOLEDO?

As of Friday, October 1st, 2021 Scale-up Systems has become part of the METTLER TOLEDO Group. Our organization will join the METTLER TOLEDO AutoChem business that is serving many of the same customers in the pharmaceutical industry. We are excited about the opportunities this important step in our company history presents.

The combination of our widely used Scale-up Suite™ process development and scale-up software with METTLER TOLEDO's market-leading products and services for biological and chemical process development creates the most comprehensive offerings for these important applications in the pharmaceutical and chemical industry.

We are committed to continuing to deliver the excellent products and customer support that our customers have come to expect from Scale-up Systems and look forward to adding the global strengths of METTLER TOLEDO.

What is process scale-up and tech transfer?

Process scale-up generally refers to increasing the production capacity by operating a chemical process in larger equipment. For example, transferring a process from the lab scale to a pilot plant or from a pilot plant to a full-scale manufacturing plant. Transferring a process across scales will often impact the physical rates in the synthesis, such as mixing, heat transfer, and mass transfer. Understanding the impact of these rates on a process is critical to designing the process to operate efficiently and robustly while producing quality products at new scales.

Transferring a process into new equipment or sites is generally referred to as a technology transfer (tech transfer) and may involve scale-up, scale-down, or scale-neutral transitions. Our process modeling software in the Scale-up Suite provides an easy-to-use and comprehensive platform for making calculations and performing simulations that can account for the physical rates, ensuring a right first time scale-up and successful tech transfer.

What is the scale-up process?

As a chemical process is developed, more material must be produced to eventually achieve commercial production demands. Often, a chemical process is scaled up several times, over orders of magnitude, from small lab bench scale to medium pilot plant facilities to large full-scale manufacturing plants.

New pharmaceuticals frequently require several scale-ups due to the increasing demands of pre-clinical studies and clinical trials before regulatory approval of the manufacturing process. Achieving quality material at expected yields when transferring a process (right first time) is important to accelerate the development of new processes and the pace of products reaching the market. Our process modeling software in the Scale-up Suite enables you to achieve these goals and accelerate process development while dealing with increasingly complex processes.