Automatic Sampling

Gain Accurate and Reliable Reaction Information With Unattended, Representative Sampling

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Some Reactions are Difficult to Sample

Without Affecting Reaction Progression

Reliably taking representative samples of oxygen or moisture-sensitive reactions and reactions at elevated pressure or sub-ambient temperatures is virtually impossible. Highly toxic reactions present additional challenges. The unique patented EasySampler probe enables the capture and immediate quenching of reactions to provide a sample representative of a reaction at the time of sampling.

EasySampler 1210

Sample and Quench at Reaction Conditions

How Does it Work?

EasySampler is immersed into a reaction, where it remains for the duration of the experiment. The sample pocket moves out and is filled with a sample. As the pocket withdraws, the sample is quenched immediately, at reaction conditions. The sample is then diluted to a user-specified concentration and ready for offline analysis.

See the Method of Sampling

Representative & Reproducible Samples

From Heterogeneous & Multiphase Reactions

Sampling reactions with precision is challenging. Sampling is especially difficult for heterogeneous and multiphase reactions. EasySampler samples from the same point in the reactor, into a pocket of fixed volume and includes solids. Solids dissolution begins immediately, with the quench and dilution steps, delivering dissolved samples to gain representative, reproducible and accurate analytical data.

Automated and Unattended 24/7

Never Miss a Sample Again

Sampling toxic or long reactions, or reactions for Design of Experiments (DoE) studies, can be impractical and cumbersome, leading to blind spots in data. This often requires repeat experiments. EasySampler samples the same way every time and can be programmed for continuous sampling operations 24/7 to provide data sets for complete reaction understanding, improving productivity.

Sample Preparation

For HPLC-Ready Concentrations

After quenching, the liquid handling system dilutes the sample to a user-specified concentration and transfers the sample to a vial, making it ready for offline analysis. These steps can be used for derivatization, decreasing sample preparation time and eliminating human error.

Sample Toxic and Hazardous Reactions and Chemistry

Eliminate User Safety Concerns

Related to Toxic and Hazardous Chemistries

EasySampler fully automates the sampling process, eliminating manual handling of liquids. This reduces risks and improves operator safety, especially with:

Highly Toxic Chemistry
Dangerous Reactions at Elevated Temperatures
Other Hazardous Reaction Conditions

Faster & Improved Chemical Development

With Integrated Reactor Systems & EasySampler

Plug-and-play integration of EasyMax Advanced, OptiMax and RX-10 with EasySampler enables faster chemical development. Automated reactors control reaction parameters while running experiments 24 hours a day. Adding EasySampler provides representative samples throughout the course of the reaction and high quality HPLC data for accurate and complete reaction profiles. iControl software controls the reactor system and EasySampler, and reports all experimental data in one file. With these integrated tools, scientists can quickly understand, innovate, and make informed decisions so that reactions can be optimized in less time.

EasySampler Connectivity Kit

Common EasySampler Automated Sampling Applications

Common EasySampler applications include:

Impurity Profiling	Air-Sensitive Reactions
Conversion	Moisture-Sensitive Reactions
Reaction Kinetics	Reactions at Sub-Ambient Temperatures
By-Product Formation	Reactions at Elevated Pressure
Yield	Hazardous and Toxic Reactions
DoE Studies	Homogeneous Reactions

Pfizer Evaluates Automated Sampling

Pfizer eliminated sampling challenges with an automated and robust inline method of taking representative samples from reactions, even under difficult conditions, for improved impurity profiling.

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eSupport for Users

Visit EasySampler eSupport for videos, manuals, application information and more.

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Products and Specs

EasySampler 1210

Material No.: 30083901

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Documentation

Documents for Unattended, Representative Sampling of Chemical Reactions

Datasheets

EasySampler

Unattended, representative automated sampling for a wide range of chemical reactions

Catalog

EasySampler Product Catalog

Eliminate chemical reaction sampling challenges by using an automated and robust method of taking representative samples

Product Documentation

EasySampler Quick Start Guide

This Quick Start Guide provides step-by-step instructions to set-up EasySampler for unattended automated sampling.

EasySampler Connectivity Kit Quick Start Guide

This Quick Start Guide provides step-by-step instructions to connect EasySampler to EasyMax, OptiMax, or RX-10 using the EasySampler Connectivity Kit.

EasySampler Operating Instructions

Operating instructions for EasySampler 1210.

Applications

Impurity Profiling of Chemical Reactions

Knowledge of impurity kinetics and mechanism of formation is important in determining reaction end-point in chemical and process development studies....

Chemical Reaction Kinetics Studies

In situ chemical reaction kinetics studies provide an improved understanding of reaction mechanism and pathway by providing concentration dependences...

Services

Services for Unattended, Representative Sampling of Chemical Reactions

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We support and service your measurement equipment through its entire life-cycle, from installation to preventive maintenance and calibration to equipment repair.

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Support

Support for EasySampler

Support Documentation

EasySampler Operating Instructions

Operating instructions for EasySampler 1210.

EasySampler Quick Start Guide

This Quick Start Guide provides step-by-step instructions to set-up EasySampler for unattended automated sampling.

EasySampler Connectivity Kit Quick Start Guide

This Quick Start Guide provides step-by-step instructions to connect EasySampler to EasyMax, OptiMax, or RX-10 using the EasySampler Connectivity Kit.

EasySampler Product Catalog

Eliminate chemical reaction sampling challenges by using an automated and robust method of taking representative samples

EasySampler FAQs

Frequently Asked Questions (FAQs) for EasySampler

EasySampler Tips and Tricks

Tips and tricks for EasySampler, including set-up, probe introduction, data management and sampling for different types of reactions.

Support Videos

Video: Change a Sleeve on the EasySampler Original Probe

Video: Change Tubing in the Original EasySampler Probe Conduit

Video: Change the Solvent Tubing

Video: Replace the Needle

Video: Change a Vial Rack

Video: Update EasySampler Firmware

Video: Replacing the EasySampler Probe Head Tubing

Video: Change a Sleeve on the New Style EasySampler Probe

Applications

Impurity Profiling of Chemical Reactions

Knowledge of impurity kinetics and mechanism of formation is important in determining reaction end-point in chemical and process development studies....

Pfizer Evaluates Automated Sampling For Improved Impurity Profiling

In Pfizer's synthetic chemistry and process development labs, an automated and robust line method is used to take representative samples from reaction...

Avoid Hydrogenation By-Products

This white paper discusses the root cause of by-product formation in a hydrogenation reaction. and how to avoid by-products during hydrogenation.

Impurity Profiling of Air-Sensitive Organometallic Reactions

New automated sampling techniques eliminate sampling challenges with an inline method of taking representative samples from reactions where manual sam...