Gravimetric Sample Preparation

Sample preparation is an important part of an analytical workflow. However, it usually consists of tedious and time-consuming manual operations. Unfortunately, labor-intensive manual processing also constitutes a high risk of error or variability, which can lead to out-of-specification (OOS) or out-of-tolerance (OOT) results (test results which fall outside of specification or tolerance acceptance criteria). Variability in sample preparation influences the accuracy of the final results of the analysis, so it is crucial to identify and eliminate any potential sources of errors before they can have an impact on downstream results.

An article published some years ago in LC/GC magazine investigated two aspects of an analytical laboratory workflow: firstly, what proportion of an analysts' time is spent on the different steps in an analytical workflow and secondly, what are the main sources of OOS errors. The results from this survey indicated that more than half (61%) of an analysts' time is spent on sample processing, and almost half (49%) of the OOS errors can be attributed to either sample processing or operator error.

So, modernizing the manual sample preparation steps of an analytical workflow – by implementing automated gravimetric sample preparation, for example – has the potential to address 50% of the issues in the workflow. This offers significant potential to improve the speed and minimize the OOS errors in the process.

This white paper describes the benefits of gravimetric sample preparation – an innovative new method for preparing samples and standards. It provides insights on how the sample preparation process can be simplified and how sample sizes can be reduced, including a direct comparison with the traditional volumetric method. Steps with a high potential for error or variability are discussed. Implementing automated gravimetric sample preparation and using Good Weighing Practice™ can significantly help to reduce data variability and OOS results. Read the white paper to understand the benefits of gravimetric sample preparation.

White Papers