Drying Oven Method vs. Halogen Moisture Analyzer
White Paper

Drying Oven Method vs. Halogen Moisture Analyzer

White Paper

A Practical Guide to Compare Methods in industries

Drying Oven Method vs. Halogen Moisture Analyzer
Drying Oven Method vs. Halogen Moisture Analyzer

Drying Oven vs. Halogen Moisture Analyzer guide will be of interest to anyone involved in moisture analysis applications in pharmaceutical, chemical, food or other industries, as moisture content affects the quality, shelf-life and usability of a wide array of end products.

This white paper explains and provides practical guidance of how halogen moisture analysis can replace the loss on drying (LOD) using a drying oven method, in order to speed up and simplify the analysis.

In the field of moisture determination using loss on drying techniques, a common question is:

"Can the drying oven method be replaced by fast halogen moisture analysis?"

The simple answer is yes, as long as the results obtained by the two methods are comparable. This means that it is necessary to show evidence that the results are equivalent within specific tolerances, which is not such a straightforward question to answer.

This white paper guides the analyst through this process. It explains the key decision criteria surrounding the choice of method and provides practical guidance on how to demonstrate that the two different methods (drying oven and halogen moisture analyzer) deliver comparable results.

In addition, two alternative and acceptable comparison approaches are outlined in this paper: the first approach is based on specific process requirements (tolerances), and the second approach is based on statistical analysis of the data obtained.

 Drying OvenHalogen Moisture Analyzer
PrincipleThermogravimetryThermogravimetry
Measuring methodHeating of sample by convection. Sample isdried in the oven for a defined period of timeat constant temperature. Mass is determinedbefore and after drying. The moisture contentpercentage is determined from the difference inweight before and after drying.Heating of sample through absorption of IRradiation from a halogen radiator.Continual determination of mass during dryingprocess. The moisture content percentage isdetermined from the difference in weight before andafter drying.
Advantages• Often reference procedure (for historicalreasons this procedure often forms part oflegislation)
• Several samples can be determined at thesame time
• Large sample volumes possible
• Quick measurement (typically 5 – 15 min.)
• Simple handling, no calculations• Compact instrument. No balance ordessicator required
• Suitable for at-line use
Disadvantages• Very long determination period (hours)
• Substances other than water may evaporate
• Prone to errors because of the high level ofhandling and calculations involved
• Unsuitable for at-line use - requires analyticalbalance and dessicator
• Substances other than water may evaporate



 
 
 
 
 
 
 
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