Development of a Transfer Hydrogenation Controlled by Nitrogen Flow
Case Study
On Demand Webinar

Development of a Transfer Hydrogenation Controlled by Nitrogen Flow

Case Study
On Demand Webinar

en Route to Belzutifan

development of a transfer hydrogenation controlled by nitrogen flow
development of a transfer hydrogenation controlled by nitrogen flow

In this presentation, we review the development of Belzutifan. Although the chemistry may present as an ordinary transfer hydrogenation, what makes this case special is how we have applied concepts of simple reaction engineering to control the process with an unusual overhead nitrogen sparge. 

Despite very aggressive timelines, this team combined expertise in chemistry, engineering, modeling and process safety to unlock a somewhat delicate but superior synthesis.

Kevin Stone | Merck
25 minutes
English