Heat Transfer and Process Scale-up

Heat Transfer and Process Scale-up

How Heat Transport in Agitated Vessels Affects Process Scale-up

Reaction Calorimetry

Applications

Applications Related to Heat Transfer and Scale-up

Mass Transfer and Reaction Rate
Mixing in a Chemical Reactor and the Effect on Reaction Kinetics and Scale-up

Mixing is the reduction or elimination of inhomogeneity of phases that are either miscible or immiscible. Process scale-up and optimization require that the impact of mixing on the reaction rate be quantified. Automated, controlled experiments can be run in parallel in a laboratory reactor system to establish a mass transfer correlation, and provide a means to quickly adjust the gas/ liquid interface area and reactor volume. This achieves the desired conditions required for the scale-up or scale-down of a process.

Chemical Synthesis
Screen and Optimize Catalysis, Hydrogenation, Polymer Synthesis and Other Reactive Chemical Syntheses

Chemists working in chemical synthesis discover and develop innovative chemical reactions and processes.

Crystallization and Precipitation
Optimize Crystal Size, Yield and Purity

Optimization and scale-up of crystallization and precipitation to produce a product that consistently meets purity, yield, form and particle size specifications can be one of the biggest challenges of process development.

Chemical Reaction Kinetics Studies
Study Chemical Reaction Rates and Measure Kinetics Inline

In situ chemical reaction kinetics studies provide an improved understanding of reaction mechanism and pathway by providing concentration dependences of reacting components in real-time. Continuous data over the course of a reaction allows for the calculation of rate laws with fewer experiments due to the comprehensive nature of the data.  Reaction Progression Kinetics Analysis (RPKA) uses in situ data under synthetically relevant concentrations and captures information throughout the whole experiment ensuring that the complete reaction behavior can be accurately described.

Chemical Process Safety
Determine the Safety of Chemical Processes Prior to Scale-up

How can I be sure that my chemical process is safe? It is critical to understand the risks inherent in moving a chemical process to a larger scale before manufacturing begins. The use of reaction calorimetry is an essential part of process development studies, providing detailed information about the rate of heat production. This allows researchers to optimize the temperature and dosing profiles to maximize process safety at all times, and reduce to a minimum the risks involved.

Mass Transfer and Reaction Rate

Mixing is the reduction or elimination of inhomogeneity of phases that are either miscible or immiscible. Process scale-up and optimization require that the impact of mixing on the reaction rate be quantified. Automated, controlled experiments can be run in parallel in a laboratory reactor system to establish a mass transfer correlation, and provide a means to quickly adjust the gas/ liquid interface area and reactor volume. This achieves the desired conditions required for the scale-up or scale-down of a process.

Chemical Synthesis

Chemists working in chemical synthesis discover and develop innovative chemical reactions and processes.

Crystallization and Precipitation

Optimization and scale-up of crystallization and precipitation to produce a product that consistently meets purity, yield, form and particle size specifications can be one of the biggest challenges of process development.

Chemical Reaction Kinetics Studies

In situ chemical reaction kinetics studies provide an improved understanding of reaction mechanism and pathway by providing concentration dependences of reacting components in real-time. Continuous data over the course of a reaction allows for the calculation of rate laws with fewer experiments due to the comprehensive nature of the data.  Reaction Progression Kinetics Analysis (RPKA) uses in situ data under synthetically relevant concentrations and captures information throughout the whole experiment ensuring that the complete reaction behavior can be accurately described.

Chemical Process Safety

How can I be sure that my chemical process is safe? It is critical to understand the risks inherent in moving a chemical process to a larger scale before manufacturing begins. The use of reaction calorimetry is an essential part of process development studies, providing detailed information about the rate of heat production. This allows researchers to optimize the temperature and dosing profiles to maximize process safety at all times, and reduce to a minimum the risks involved.

Publications

Publications on Heat Transfer and Scale-up

Application Notes

Heat Transport in Agitated Vessels
This application note describes how reaction calorimetry provides accurate measurement of the thermal resistances and the heat evolved from reactions...

Webinars

Reaction Calorimetry in the Chemical Industry
This webinar focuses on applications and the importance of mixing and reaction calorimetry in the chemical process industry. A series of industrial ca...

Related Products

Technology related to Heat Transfer and Scale-up

 
 
 
 
 
 
 
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