Estimate Stoessel Classification for Reaction Hazards

On-demand webinar sharing methodology to effectively estimate the Stoessel criticality class of any process by just using a small-scale experiment.

The Stoessel criticality class is well-known among the Process Safety community to systematically assess the thermal risks associated to the scale up of chemical processes. Such a classification can be obtained after the full characterization of the chemical process by calorimetric techniques (e.g. RC1 and DSC), unfortunately, this usually requires dedicated experiments at the Process Safety lab and involves lengthy calibrations to characterize the thermal behavior of the system (i.e. heat capacity and heat transfer). Therefore, having a simplified methodology would avoid compromising the agility required at early stages of a research project.

In this webinar we will share a methodology to effectively estimate the Stoessel classification of any process by just using a small-scale experiment, recorded in an automated synthesis reactor, in combination with the previous calorimetric characterization of the typical solvents used in pharmaceutical development.

Key learning objectives:

  • Reaction calorimetry
  • Process safety
  • Stoessel classification

About the Presenter

Dr. Albert Colomer

Dr. Albert Colomer

Head of Process Safety, UCB Pharma S.A.

Dr. Albert Colomer obtained his degree in chemical engineering as well as a PhD in process chemistry in Barcelona, furthermore, he recently completed a Master of Science in pharmaceutical development from KU Leuven. He worked for almost 8 years as a specialist in process safety for AkzoNobel in The Netherlands, where he focused on different aspects of product safety by the thorough characterization of flammability as well explosivity properties; additionally, he facilitated multiple HazOp studies on organic peroxides and metal alkyl production units located worldwide. In 2019 he joined UCB Pharma in Belgium as their Head of Process Safety, where he is accountable for the assessment all safety aspects associated to the scale-up of any chemical process related to development of small molecules; this includes the characterization of reaction hazards as well as product thermostability.