Multi-Scale PAT for Small Molecule Development
Zachary Dance describes how Merck's small molecule R&D group leverages Process Analytical Technology (PAT) to collect data often considered inaccessible. Data-Rich Experimentation (DRE) is one of the primary strategic areas of focus within Merck Research Laboratories, Process Research and Development. The objective is to significantly enhance the ability to generate and analyze data with the efficiency and productivity needed to achieve efficient drug invention, development, and commercialization. One of the key components of the DRE strategy is enabling widespread use of Process Analytical Technology (PAT).
Dr. Dance presents the current state of Merck Research Laboratories’ small molecule PAT toolset. He discusses the integration of modern instrumentation from lab to pilot scale, and includes select examples where PAT was utilized to enhance process understanding.
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