Importance of Mixing

Compare Lab Scale Mixing with Full Scale Process Vessel Performance

This webinar discusses the importance of mixing and compares lab mixing and large scale mixing. The presentation features excerpts from two short courses given by Reinaldo Machado entitled Fundamentals of Scale-up and iControl Mixing Guidelines.

Process objectives are critical for successful manufacturing of a product. If the mixing scale-up fails the required yield, quality, or physical properties of the product and the costs of manufacturing may be significantly increased. Failure to provide the necessary mixing may result in severe manufacturing problems on scale-up, ranging from costly corrections in the plant to complete failure of a process. The costs associated with these problems are far greater than the cost of adequately evaluating and solving the mixing issues during process development. Conversely, the economic potential of improved mixing performance is substantial. Therefore, at the heart of any scale-up chemical process, there has to be a fundamental understanding of how the mixing processes in a lab reactor compares to the mixing performance of a full scale process vessel which is targeted to receive the lab developed process.

About the Presenter

Reinaldo Machado

Reinaldo Machado

rm2technologies LLC

Reinaldo (Ray) Machado is president of rm2 technologies LLC, a company focused on teaching the application of mixing technology. He is also employed by Air Products and Chemicals, Inc. where he serves as a senior consultant specializing in gas-liquid reaction engineering. He has managed a number of technical development and applications teams and has experience in applied reactor engineering, scale-up of chemical reaction processes, mass transfer, heat transfer, and reaction calorimetry. Ray received a Ph.D. in chemical engineering from the University of Wisconsin, Madison. He has served as a part-time instructor at Lehigh University and currently teaches industrial courses on the fundamentals of scale-up. He holds 17 patents, has collaborated on 17 publications.