EasyViewer as an In-Line Camera in Bioreactors
Observe Bioreactor Cultures in Real-Time
Tổng quan chương trình
- The sampling effect (off-line samples not being representative) highlights the importance of in-line PAT
- The in-line camera can be used to optimize multiple upstream process steps such as trypsinization and viral culture duration
- Parameters can be extracted from the images to extrapolate cell concentration and viability of the cell culture in real-time
Vivian Ma, Ph.D. of Sanofi presents, EasyViewer as an in-line camera in bioreactors, describing the use of EasyViewer particle analyzer probe as an in-line camera to observe bioreactor cell cultures in real-time. It exemplifies the sampling effect by demonstrating the difference between what is happening in the bioreactor compared to what was observed from off-line samples. Vivian then presents case studies of how EasyViewer can be used to optimize different process steps including trypsinization and viral culture harvest. This presentation also discusses the potential of using the EasyViewer probe to track various cell culture parameters (such as cell concentration and viability) in real-time. This inline PAT approach enables automated, closed-loop control to improve product quality, yield, and process consistency.
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Target audience
Upstream scientist and operators who perform bioreactor cultures.
About the Presenter
Yu-Heng (Vivian) Ma, Ph.D.
Scientist, Sanofi
Vivian is a scientist at Sanofi specializing in vaccine drug substance development. She has a Ph.D. in biomedical engineering from University of Toronto and has expertise in upstream cell culture and downstream purification processes.
