Development of a Semi-Continuous Manufacturing Process
On Demand Webinar

Development of a Semi-Continuous Manufacturing Process

On Demand Webinar

Enabled by Process Analytical Technology (PAT)

Development of a Semi-Continuous Manufacturing Process
Development of a Semi-Continuous Manufacturing Process

Continuous processing provides an alternative path to approach process development. Particularly for hazardous syntheses, operating in flow offers significant advantages over the conventional batch mindset of the pharmaceutical industry. Ethyl diazoacetate, a commonly used cyclopropanating reagent, is a great example due to the exothermicity of its synthesis as well as the reactivity and explosivity concerns associated with its storage and transportation.

In this webinar, Ronald Carrasquillo of Bristol Myers Squibb discusses the development of a flow process to safely synthesize ethyl diazoacetate, as well as consume it in a downstream fed-batch reaction, to minimize its handling. The start-to-end process encompasses:

  • A diazotization in flow
  • Aqueous extractions and phase separations
  • Inline degassing
  • Fed-batch cyclopropanation

The use and selection of PAT tools was crucial to the progress of process development and the learnings derived from their application with regards to monitoring and process control and will be a focus of discussion.

Join the hundreds of researchers who have already viewed this presentation.

Ronald Carrasquillo - Bristol Myers Squibb
23 Minutes
English

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