Enhance Process Development in Flow Leveraging Inline DRE and Automation
On Demand Webinar

Enhance Process Development in Flow Leveraging Inline DRE and Automation

On Demand Webinar

Address the Resource Burden in Flow Chemistry

Enhance Process Development in Flow Leveraging Inline DRE and Automation
Enhance Process Development in Flow Leveraging Inline DRE and Automation

Advancements in continuous processing technologies in parallel with the expansion of complex organic reactions enabled by flow chemistry have led to the increasing use of flow reactions throughout the pharmaceutical industry. However, reaction development in flow is typically plagued by inefficiencies associated with collecting data under steady-state conditions and data-rich experimentation options for characterizing flow reactions remain sparse. In the early stages of drug development, this challenged is compounded by limited availability of key raw materials and short development timelines.

Automated transient/dynamic reaction experiments provide a viable process development intensification option to lessen the resource burden and inefficiencies surrounding flow reaction process development. Moreover, appropriate coupling of this technique with inline Process Analytical Technologies enables the generation of rich datasets during extended, unattended experiments, such as stability studies or integrated reaction self-optimization. In this presentation, Brian Wyvratt discusses examples of how Merck leverages automated flow systems to improve knowledge capture while limiting resource burdens.


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Brian M. Wyvratt - Merck & Co., Inc.
27 Minutes
English

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