The compact, high-performance ReactRaman Raman Spectrometer, coupled with iC Raman 7 and trusted service and support, provides critical insight – even for the most challenging reactions. ReactRaman is ideal for:
One Click Analytics (only available in iC Raman 7) means that whether you are an expert, or new to Raman Spectrometers, data collection and analysis is fast and accurate.
Small Footprint, Big Performance
ReactRaman Raman Spectrometer combines best-in-class performance with a flexible and portable design; delivering outstanding results wherever it’s needed - on the bench, in the fume hood, or in the lab next door.
One Click Analytics
Designed specifically for time-resolved reaction analysis, iC Raman software combines a peak picking algorithm with functional group intelligence to drastically reduce analysis time. Users combine knowledge of their chemistry with an automated data analysis workflow to ensure correct interpretation for every experiment.
In Situ Probes Optimized for Quality Answers
Raman spectrometer probe- and flow-based sampling technologies are optimized for crystallization and polymorph chemistry investigation. Fit-for-purpose materials of construction make data collection straightforward in acidic and corrosive environments across a wide range of temperatures and pressures.
Additional Understanding for Your Reaction Analysis
Raman spectrometers provide complimentary, but different, information to FTIR. While FTIR gives users functional group information, Raman provides backbone and structural information. When combined with FTIR, the user can obtain key information regardless of the sample physical state, giving its user a full picture of their reaction.
Reaction Analysis Expertise
As a company, METTLER TOLEDO has over 30 years of dedicated reaction analysis experience. This is our focus and our passion. For our Raman spectrometer, this is revealed in the details. Our probes and instrumentation have been optimized for detection. Our software was configured to guide the users through collection and analysis steps for results confidence. Our trusted service and support teams ensure success for the scientist.
Comprehensive Reaction Understanding
with ReactRaman Raman Spectrometer
In order to understand chemical reactions, chemists use Raman Spectrometers to address the following:
When does the reaction start? When does the reaction stop?
What polymorph is being produced?
What are the reaction kinetics, mechanism, or crystallization process?
Did it react as expected? Did any by products form, and why?
What happens if reaction temperature, dosing rates, or mixing rates change?
Traditionally, to obtain reaction information, samples are taken for offline analysis using HPLC. For chemistries in which sample removal results in the loss of key information, or are toxic or otherwise hazardous, this procedure is not straightforward. Furthermore, chemists must be present to take the sample and then wait for the results before reaction analysis can begin.
With inline Raman Spectrometers, continuous monitoring allows users to trend components over time for a 'molecular video' of the reaction - making it easy to answer critical questions for reaction and process optimization.
Polymorph Detection in Carbamazepine
ReactRaman Raman Spectrometer in Action
Reveal Reaction Mechanisms In this example, ReactRaman Raman Spectrometer follows the conversion of Carbamazepine anhydrate to the dihydrate form while showing the full conversion time
Provide Insight Into Distinguishing Polymorphs At times, polymorphs can not be identified visibly. ReactRaman provides molecular information to help the user understand more from their crystallization processes
Track Reaction Progress for Better Yield & Purity Determination of optimal reaction or crystallization endpoint
Measure Form Stability Conversion of polymorphs can be monitored providing insight into stability of products
Quickly Determine Kinetics First order reaction kinetics in one experiment
Raman Spectrometer Applications
ReactRaman in Industry
ReactRaman Spectrometer works in a wide range of chemistries in which the molecule is Raman active, the chemistry is in solution, multiphasic or solids, and the concentration is higher than ~0.1 %.
Below is a selection of publications featuring raman spectrometers.
Shihao Zhang, Ling Zhou, Wenchao Yang, Chuang Xie, Zhao Wang, Baohong Hou, Hongxun Hao, Lina Zhou, Ying Bao, Qiuxiang Yin; An Investigation into the Morphology Evolution of Ethyl Vanillin with the Presence of a Polymer Additive Cryst. Growth Des. 2020
Jiayu Dai, Lihong Jia, Wenchao Yang, Dan Zhu, Chuang Xie, Ying Bao, Ling Zhou, Qiuxiang Yin Solid Forms Selection of Spironolactone Ternary Phase Diagram and Nucleation Process Ind. Eng. Chem. Res 2020,59,3,1350-1361
An Integrated Approach
for Comprehensive Understanding & Control
ReactRaman Raman Spectrometer is part of an integrated family of products, which includes:
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