Digital Sensor Integration
Connect ISM pH and Optical DO Sensors to Bioreactors
Integrate Sensors into Reactors and Controllers
Transmitters, junction boxes, and adaptors connect digital ISM pH/ORP, dissolved oxygen, and carbon dioxide sensors to biocontrollers, both in digital and analog controllers.
Convenient Process Calibration
Replacing a biocontroller is costly, especially in regulated production. These integration tools let an analog biocontroller accept digital ISM pH and optical dissolved oxygen sensors instead.
Calibrate Away From the Process
Plug and Measure allows ISM sensors to be pre-calibrated in a convenient location. The calibration data is stored in the sensor, so a pre-calibrated sensor can be installed and used straightaway.
Access ISM Diagnostics Without a Full Transmitter
Bluetooth-enabled integration tools make ISM diagnostics such as the Dynamic Lifetime Indicator and the Adaptive Calibration Timer available on ISM Core software directly at the measurement point.
Record Calibration Data for Compliance
Calibration performed at the reactor is stored in the sensor and can be transferred to ISM Core software for asset management and record keeping in regulated production.
Compact Sensor-Mount Transmitters
M100 SM transmitters mount directly on the sensor and deliver the measurement signal to the biocontroller, eliminating the need for a panel- or wall-mounted transmitter.
Useful Related Links
Intelligent Sensor Management - ISM
Intelligent Sensor Management, ISM™ is a digital technology for process analytics. Measurements from ISM sensors are highly reliable and help you maintain process consistency. Data and ISM's advanced sensor diagnostics can be easily transferred to wherever needed and support true predictive maintenance planning. Learn more now.
ISM Core Software
Connect your ISM sensors to software to calibrate them to the accuracy of lab conditions, assess their state with real-time diagnostics and record their operating history.
Intelligent Transmitter Series Brochure
This brochure provides an overview of METTLER TOLEDO’s Intelligent Transmitter Series, featuring solutions designed to meet the demands of a wide range of process and water industry applications. The brochure also highlights transmitter compatibility with both conventional analog sensors and digital sensors equipped with Intelligent Sensor Management (ISM™) technology, making it easier to integrate advanced analytical measurements into existing systems.
White Paper: pH Measurement in Bioprocesses
This white paper presents tips that can help you stay in control of your pH measurements in bioprocesses by minimizing errors and achieving higher process reliability. It provides a list of recommended METTLER TOLEDO pH sensors.
pH Sensor Calibration Guide
pH systems with Intelligent Sensor Management (ISM) drastically minimize the maintenance and workload, meaning far less time spent at measurement points. Find out everything you need to know about getting the most from your pH sensors in our new guide.
Webinar: Dissolved Oxygen in Biopharma
Dissolved oxygen levels in an aerobic fermentation or cell culture broth is one of the critical key variables in upstream biomanufacturing. In this webinar, we will explore how DO control strategies can be utilized for maximizing product titers and yields.
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FAQs
What is digital sensor integration?
Digital sensor integration is the connection of digital analytical sensors to a bioreactor, biocontroller, or control system. For METTLER TOLEDO ISM sensors this is done with sensor-mount transmitters, junction boxes, and adaptors, which convert the digital sensor signal into the input the controller expects and give access to ISM diagnostics.
Can I connect an ISM sensor to a bioreactor built for analog sensors?
Yes. A J-Box BTLE converts the digital ISM signal into an analog input that an existing biocontroller can accept. This allows an analog reactor to be upgraded to digital ISM pH sensors or to optical dissolved oxygen sensors without replacing the reactor or the control system.
What is a sensor-mount transmitter?
A sensor-mount transmitter is a compact transmitter that mounts directly on the sensor rather than in a panel or on a wall. Available in 1-wire and RS-485 versions, the M100 SM passes the measurement signal to the biocontroller, helping minimize installation footprint and reduce cabling at the reactor.
Do I need a transmitter to see ISM diagnostics?
No. Integration tools with Bluetooth allow ISM diagnostics, such as the Dynamic Lifetime Indicator and the Adaptive Calibration Timer, to be read on ISM Core software without a full transmitter. Process calibrations can also be performed this way, and the calibration data is stored in the sensor and can later be transferred to ISM Core software.
Which measurements can be integrated with these accessories?
Digital sensor integration accessories support ISM pH/ORP sensors, optical and amperometric dissolved oxygen sensors, and dissolved carbon dioxide sensors. The accessory you need depends on the sensor connection type, either 1-wire or RS-485.
What is the benefit of digital sensors in process development?
In process development, measurement points are set up and reconfigured frequently. Digital integration tools make it easy to move sensors between reactors, and because calibration data is stored in the sensor, a calibrated sensor can be connected and used immediately. ISM diagnostics also record how each sensor has been used across runs. Sensor calibrations can be performed conveniently in the field.