Automated Reactors & In-Situ Analysis for Chemical Process Development
Automated synthesis reactors and controlled laboratory reactors replace traditional round bottom flasks or jacketed lab reactors. This allows che...
Automated synthesis reactors and controlled laboratory reactors replace traditional round bottom flasks or jacketed lab reactors. This allows chemical synthesis researchers to explore new reaction conditions and develop innovative chemistry. Engineers apply an advanced version of these automated laboratory reactor (ALR) systems to measure real time reaction calorimetry, heat of reaction, and thermodynamic data for process safety understanding and control.
Unattended, fully automated sampling of chemical reactions, including slurries, enable chemists and engineers to gain samples throughout the reaction, providing valuable information. With the unique patented sampling probe, EasySampler quenches the sample at the point of sampling and at reaction conditions, proving a truly representative sample for accurate analytical data.
In-situ reaction analysis with Attenuated Total Reflection (ATR) - Fourier Transform Infrared (FTIR) spectrometers provide real time monitoring of key reaction species. By following reaction progression, initiation, conversion, intermediate formation and endpoints, these tools optimize process design and quality. Increased process knowledge from inline reaction analysis supports the development of batch or continuous flow chemistry and enables chemical reactions to be scaled-up.
Inline particle size analyzers enable scientists and engineers to track the rate and degree of change to particles, crystals or droplets as they naturally exist in process. By understanding how particles change in real time, engineers can track batch to batch consistency, detect endpoints and optimize downstream throughput and product quality.
Our inline PAT technologies are probe-based instruments that track critical process parameters and quality attributes for Quality by Design (QbD) requirements. Lab PAT instruments help design a quality process. Plant PAT tools enable monitoring and control of a process.
Integrated software enables researchers to combine all technology in a simple and powerful platform, which captures data, visualizes and interprets experiments, prepares and report results, and compares batches or experiments.
In-situ FTIR spectrometers enable scientists to gain insight into their reactions and processes in a wide range of applications. Optimize reaction variables with inline FTIR instru...
Chemical reactor sampling equipment takes reliable analytical samples inline, quenches in situ, and dilutes for reproducible analytical samples from almost any chemical reaction.
Scale-up Suite™ is the world’s leading drug substance process development and scale-up software for scientists and engineers working in the pharmaceutical industry.
Applications
Crystallization, Organic Synthesis, Process Development, Safety, PAT Applications
Chemical synthesis occurs when two or more molecules are combined to form a product molecule that possesses specific properties. There are numerous examples of chemical synthesis t...
By understanding crystallization processes and choosing the right parameters, it is possible to consistently produce crystals of the correct size, shape and purity while minimizing...
Chemical Process Development and Scale-Up guides the development of a commercially important molecule from synthesis in the lab to large scale manufacture of a quality product.
Chemical process safety focuses on preventing incidents and accidents during manufacturing of chemicals and pharmaceuticals on a large scale. It refers to unintentional release of...
Process Analytical Technology (PAT) is a system for designing, analyzing and controlling manufacturing with the goal of ensuring final product quality.
Solid and liquid formulations are influenced by particle and droplet size. Particles and droplets affect the bioavailility, stability, and manufacturability of formulations includ...
Parallel Synthesis accelerates the discovery of potential drug candidates and screen for optimal process conditions as the molecule proceeds through development phases. Instead of...
Continuous flow chemistry opens options with exothermic synthetic steps that are not possible in batch reactors, and new developments in flow reactor design provide alternatives fo...
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