Achieve consistent primary nucleation and avoid secondary nucleation events.
Enhance growth over nucleation to increase crystal size.
3. Oiling Out
Determine the phase diagram and avoid conditions where oiling out occurs.
Avoid agglomeration through solvent selection and parameter control.
Avoid unwanted breakage and addition and control desired wet-milling.
Optimize seeding protocol to deliver desired particle properties.
7. Polymorph Transformation
Navigate the phase diagram to produce the desired form.