Crystallization Optimization and Scale-Up Best Practices - METTLER TOLEDO

Crystallization Optimization and Scale-Up Best Practices

Optimization and scale-up of crystallization and precipitation to produce a product that consistently meets purity, yield, form and particle size specifications can be one of the biggest challenges of process development.  The use of Process Analytical Technology (PAT) tools for real-time monitoring of the crystal distribution and population (using FBRM® and PVM®) and the supersaturation driving force (with ReactIR™) have simplified the understanding, optimization and control of crystallization.  The integration of PAT tools with synthesis workstations ensures the precise monitoring and control of critical process variables and a more accurate determination of the acceptable and optimal design space for the crystallization step.

Crystallization White Papers

Popular Crystallization On-Demand Webinars

Thank you for visiting We have tried to optimize your experience while on the site, but we noticed that you are using an older version of a web browser. We would like to let you know that some features on the site may not be available or may not work as nicely as they would on a newer browser version. If you would like to take full advantage of the site, please update your web browser to help improve your experience while browsing