Sistema de muestreo automatizado ▶ Muestreo sin supervisión

¿Por qué automatizar el muestreo de las reacciones químicas?

EasySampler, esencial para la experimentación con abundancia de datos

Muestreo automatizado en publicaciones de revistas recientes

El muestreo automatizado continuo con el modelo EasySampler facilita los estudios de perfiles de reacción e impurezas. Una lista de publicaciones de revistas revisadas por pares se centra en las emocionantes y novedosas aplicaciones de EasySampler por parte de investigadores tanto del mundo académico como de la industria para apoyar la experimentación rica en datos para avanzar en su investigación.

  • Lomont, J. P., Ralbovsky, N. M., Guza, C., Saha-Shah, A., Burzynski, J., Konietzko, J., Wang, S.-C., McHugh, P. M., Mangion, I., & Smith, J. P. (2022). Process monitoring of polysaccharide deketalization for vaccine bioconjugation development using in situ analytical methodology. Journal of Pharmaceutical and Biomedical Analysis209, 114533. https://doi.org/10.1016/j.jpba.2021.114533
  • Ashworth, I. W., Frodsham, L., Moore, P., & Ronson, T. O. (2021). Evidence of Rate Limiting Proton Transfer in an SNAr Aminolysis in Acetonitrile under Syntheticall...
Mostrar más

El muestreo automatizado continuo con el modelo EasySampler facilita los estudios de perfiles de reacción e impurezas. Una lista de publicaciones de revistas revisadas por pares se centra en las emocionantes y novedosas aplicaciones de EasySampler por parte de investigadores tanto del mundo académico como de la industria para apoyar la experimentación rica en datos para avanzar en su investigación.

  • Lomont, J. P., Ralbovsky, N. M., Guza, C., Saha-Shah, A., Burzynski, J., Konietzko, J., Wang, S.-C., McHugh, P. M., Mangion, I., & Smith, J. P. (2022). Process monitoring of polysaccharide deketalization for vaccine bioconjugation development using in situ analytical methodology. Journal of Pharmaceutical and Biomedical Analysis209, 114533. https://doi.org/10.1016/j.jpba.2021.114533
  • Ashworth, I. W., Frodsham, L., Moore, P., & Ronson, T. O. (2021). Evidence of Rate Limiting Proton Transfer in an SNAr Aminolysis in Acetonitrile under Synthetically Relevant Conditions. The Journal of Organic Chemistry. https://doi.org/10.1021/acs.joc.1c01768
  • Pollack, S. R., & Dion, A. (2021). Metal-Free Stereoselective Synthesis of (E)- and (Z)-N-Monosubstituted β-Aminoacrylates via Condensation Reactions of Carbamates. The Journal of Organic Chemistry86(17), 11748–11762. https://doi.org/10.1021/acs.joc.1c01212
  • Zhao, X., Webb, N. J., Muehlfeld, M. P., Stottlemyer, A. L., & Russell, M. W. (2021). Application of a Semiautomated Crystallizer to Study Oiling-Out and Agglomeration Events—A Case Study in Industrial Crystallization Optimization. Organic Process Research & Development25(3), 564–575. https://doi.org/10.1021/acs.oprd.0c00494
  • Jurica, J. A., & McMullen, J. P. (2021). Automation Technologies to Enable Data-Rich Experimentation: Beyond Design of Experiments for Process Modeling in Late-Stage Process Development. Organic Process Research & Development25(2), 282–291. https://doi.org/10.1021/acs.oprd.0c00496
  • Malig, T. C., Yunker, L. P. E., Steiner, S., & Hein, J. E. (2020). Online High-Performance Liquid Chromatography Analysis of Buchwald–Hartwig Aminations from within an Inert Environment. ACS Catalysis10(22), 13236–13244. https://doi.org/10.1021/acscatal.0c03530
  • Malig, T. C., Tan, Y., Wisniewski, S. R., Higman, C. S., Carrasquillo-Flores, R., Ortiz, A., Purdum, G. E., Kolotuchin, S., & Hein, J. E. (2020). Development of a telescoped synthesis of 4-(1H)-cyanoimidazole core accelerated by orthogonal reaction monitoring. Reaction Chemistry & Engineering5(8), 1421–1428. https://doi.org/10.1039/d0re00234h
  • Wang, K., Han, L., Mustakis, J., Li, B., Magano, J., Damon, D. B., Dion, A., Maloney, M. T., Post, R., & Li, R. (2019). Kinetic and Data-Driven Reaction Analysis for Pharmaceutical Process Development. Industrial & Engineering Chemistry Research59(6), 2409–2421. https://doi.org/10.1021/acs.iecr.9b03578
  • Beutner, G. L., Coombs, J. R., Green, R. A., Inankur, B., Lin, D., Qiu, J., Roberts, F., Simmons, E. M., & Wisniewski, S. R. (2019). Palladium-Catalyzed Amidation and Amination of (Hetero)aryl Chlorides under Homogeneous Conditions Enabled by a Soluble DBU/NaTFA Dual-Base System. Organic Process Research & Development23(8), 1529–1537. https://doi.org/10.1021/acs.oprd.9b00196
  • Huffman, M. A., Fryszkowska, A., Alvizo, O., Borra-Garske, M., Campos, K. R., Canada, K. A., Devine, P. N., Duan, D., Forstater, J. H., Grosser, S. T., Halsey, H. M., Hughes, G. J., Jo, J., Joyce, L. A., Kolev, J. N., Liang, J., Maloney, K. M., Mann, B. F., Marshall, N. M., & McLaughlin, M. (2019). Design of an in vitro biocatalytic cascade for the manufacture of islatravir. Science366(6470), 1255–1259. https://doi.org/10.1126/science.aay8484
  • Mennen, S. M., Alhambra, C., Allen, C. L., Barberis, M., Berritt, S., Brandt, T. A., Campbell, A. D., Castañón, J., Cherney, A. H., Christensen, M., Damon, D. B., Eugenio de Diego, J., García-Cerrada, S., García-Losada, P., Haro, R., Janey, J., Leitch, D. C., Li, L., Liu, F., Lobben, P. C., MacMillan, D. W. C., Magano, J., McInturff, E., Monfette, S., Post, R. J., Schultz, D., Sitter, B., Stevens, J. M., Strambeanu, I. I., Twilton, J., Wang, K., & Zajac, M. A. (2019). The Evolution of High-Throughput Experimentation in Pharmaceutical Development and Perspectives on the Future. Organic Process Research & Development23(6), 1213–1242. https://doi.org/10.1021/acs.oprd.9b00140
  • Carter, H. L., Connor, A. W., Hart, R., McCabe, J., McIntyre, A. C., McMillan, A. E., Monks, N. R., Mullen, A. K., Ronson, T. O., Steven, A., Tomasi, S., & Yates, S. D. (2019). Rapid route design of AZD7594. Reaction Chemistry & Engineering4(9), 1658–1673. https://doi.org/10.1039/c9re00118b
  • Zawatzky, K., Grosser, S., & Welch, C. J. (2017). Facile kinetic profiling of chemical reactions using MISER chromatographic analysis. Tetrahedron73(33), 5048–5053. https://doi.org/10.1016/j.tet.2017.05.048
  • Gurung, S. R., Mitchell, C., Huang, J., Jonas, M., Strawser, J. D., Daia, E., Hardy, A., O’Brien, E., Hicks, F., & Papageorgiou, C. D. (2016). Development and Scale-up of an Efficient Miyaura Borylation Process Using Tetrahydroxydiboron. Organic Process Research & Development21(1), 65–74. https://doi.org/10.1021/acs.oprd.6b00345
  • Rougeot, C., Situ, H., Cao, B. H., Vlachos, V., & Hein, J. E. (2017). Automated reaction progress monitoring of heterogeneous reactions: crystallization-induced stereoselectivity in amine-catalyzed aldol reactions. Reaction Chemistry & Engineering2(2), 226–231. https://doi.org/10.1039/c6re00211k
  • Duan, S., Place, D., Perfect, H. H., Ide, N. D., Maloney, M., Sutherland, K., Price Wiglesworth, K. E., Wang, K., Olivier, M., Kong, F., Leeman, K., Blunt, J., Draper, J., McAuliffe, M., O’Sullivan, M., & Lynch, D. (2016). Palbociclib Commercial Manufacturing Process Development. Part I: Control of Regioselectivity in a Grignard-Mediated SNAr Coupling. Organic Process Research & Development, 20(7), 1191–1202. https://doi.org/10.1021/acs.oprd.6b00070
  • Malig, T. C., Koenig, J. D. B., Situ, H., Chehal, N. K., Hultin, P. G., & Hein, J. E. (2017). Real-time HPLC-MS reaction progress monitoring using an automated analytical platform. Reaction Chemistry & Engineering, 2(3), 309–314. https://doi.org/10.1039/c7re00026j
  • Nykaza, T. V., Ramirez, A., Harrison, T. S., Luzung, M. R., & Radosevich, A. T. (2018). Biphilic Organophosphorus-Catalyzed Intramolecular Csp2–H Amination: Evidence for a Nitrenoid in Catalytic Cadogan Cyclizations. Journal of the American Chemical Society, 140(8), 3103–3113. https://doi.org/10.1021/jacs.7b13803
Mostrar menos