자동 샘플링 시스템 | 무인 샘플링

화학 반응에 대해 자동 샘플링이 필요한 이유는 무엇인가요?

EasySampler – 데이터가 풍부한 실험에 매우 중요

pfizer automated sampling

Pfizer Evaluates Automated Sampling for Improved Impurity Profiling

Unattended, Representative Sampling of a Wide Range of Chemical Reactions

EasySampler Tips and Tricks

EasySampler Tips and Tricks

Tips and tricks for automated sampling, including set-up, probe introduction, data management and sampling for different types of reactions.

pfizer autosampling

Sampling of Chemical Reactions at Pfizer

Automated Chemical Reaction Sampling

The Modern Synthesis Lab

The Modern Synthesis Lab

A New Workplace for Chemists

Endpoint Detection of a Hydrogenation

Endpoint Detection of a Hydrogenation

Sampling Reactions at Elevated Pressure

최근 학술지 간행물에서의 자동 샘플링

EasySampler를 사용하는 지속적인 자동 샘플링은 반응 및 불순물 프로파일링 연구를 뒷받침합니다. 전문가 대상 학술지에 실린 간행물 목록은 학계 및 업계 양측의 연구자들이 EasySampler를 새롭고 흥미로운 방식으로 적용하는 것에 초점을 맞춘 것으로, 데이터가 풍부한 실험을 뒷받침하여 이들의 연구를 발전시키기 위함입니다.

  • Lomont, J. P., Ralbovsky, N. M., Guza, C., Saha-Shah, A., Burzynski, J., Konietzko, J., Wang, S.-C., McHugh, P. M., Mangion, I., & Smith, J. P. (2022). Process monitoring of polysaccharide deketalization for vaccine bioconjugation development using in situ analytical methodology. Journal of Pharmaceutical and Biomedical Analysis209, 114533. https://doi.org/10.1016/j.jpba.2021.114533
  • Ashworth, I. W., Frodsham, L., Moore, P., & Ronson, T. O. (2021). Evidence of Rate Limiting Proton Transfer in an SNAr Aminolysis in Acetonitrile under Synthetically Relevant Conditions. The Journal of Organic Chemistry. https://doi.org/10.1021/acs.joc.1c01768
  • Pollack, S. R., & Dion, A. (2021). Metal-Free Stereoselective Synthesis of (E)- and (Z)-N-Monosubstituted β-Ami...
더보기

EasySampler를 사용하는 지속적인 자동 샘플링은 반응 및 불순물 프로파일링 연구를 뒷받침합니다. 전문가 대상 학술지에 실린 간행물 목록은 학계 및 업계 양측의 연구자들이 EasySampler를 새롭고 흥미로운 방식으로 적용하는 것에 초점을 맞춘 것으로, 데이터가 풍부한 실험을 뒷받침하여 이들의 연구를 발전시키기 위함입니다.

  • Lomont, J. P., Ralbovsky, N. M., Guza, C., Saha-Shah, A., Burzynski, J., Konietzko, J., Wang, S.-C., McHugh, P. M., Mangion, I., & Smith, J. P. (2022). Process monitoring of polysaccharide deketalization for vaccine bioconjugation development using in situ analytical methodology. Journal of Pharmaceutical and Biomedical Analysis209, 114533. https://doi.org/10.1016/j.jpba.2021.114533
  • Ashworth, I. W., Frodsham, L., Moore, P., & Ronson, T. O. (2021). Evidence of Rate Limiting Proton Transfer in an SNAr Aminolysis in Acetonitrile under Synthetically Relevant Conditions. The Journal of Organic Chemistry. https://doi.org/10.1021/acs.joc.1c01768
  • Pollack, S. R., & Dion, A. (2021). Metal-Free Stereoselective Synthesis of (E)- and (Z)-N-Monosubstituted β-Aminoacrylates via Condensation Reactions of Carbamates. The Journal of Organic Chemistry86(17), 11748–11762. https://doi.org/10.1021/acs.joc.1c01212
  • Zhao, X., Webb, N. J., Muehlfeld, M. P., Stottlemyer, A. L., & Russell, M. W. (2021). Application of a Semiautomated Crystallizer to Study Oiling-Out and Agglomeration Events—A Case Study in Industrial Crystallization Optimization. Organic Process Research & Development25(3), 564–575. https://doi.org/10.1021/acs.oprd.0c00494
  • Jurica, J. A., & McMullen, J. P. (2021). Automation Technologies to Enable Data-Rich Experimentation: Beyond Design of Experiments for Process Modeling in Late-Stage Process Development. Organic Process Research & Development25(2), 282–291. https://doi.org/10.1021/acs.oprd.0c00496
  • Malig, T. C., Yunker, L. P. E., Steiner, S., & Hein, J. E. (2020). Online High-Performance Liquid Chromatography Analysis of Buchwald–Hartwig Aminations from within an Inert Environment. ACS Catalysis10(22), 13236–13244. https://doi.org/10.1021/acscatal.0c03530
  • Malig, T. C., Tan, Y., Wisniewski, S. R., Higman, C. S., Carrasquillo-Flores, R., Ortiz, A., Purdum, G. E., Kolotuchin, S., & Hein, J. E. (2020). Development of a telescoped synthesis of 4-(1H)-cyanoimidazole core accelerated by orthogonal reaction monitoring. Reaction Chemistry & Engineering5(8), 1421–1428. https://doi.org/10.1039/d0re00234h
  • Wang, K., Han, L., Mustakis, J., Li, B., Magano, J., Damon, D. B., Dion, A., Maloney, M. T., Post, R., & Li, R. (2019). Kinetic and Data-Driven Reaction Analysis for Pharmaceutical Process Development. Industrial & Engineering Chemistry Research59(6), 2409–2421. https://doi.org/10.1021/acs.iecr.9b03578
  • Beutner, G. L., Coombs, J. R., Green, R. A., Inankur, B., Lin, D., Qiu, J., Roberts, F., Simmons, E. M., & Wisniewski, S. R. (2019). Palladium-Catalyzed Amidation and Amination of (Hetero)aryl Chlorides under Homogeneous Conditions Enabled by a Soluble DBU/NaTFA Dual-Base System. Organic Process Research & Development23(8), 1529–1537. https://doi.org/10.1021/acs.oprd.9b00196
  • Huffman, M. A., Fryszkowska, A., Alvizo, O., Borra-Garske, M., Campos, K. R., Canada, K. A., Devine, P. N., Duan, D., Forstater, J. H., Grosser, S. T., Halsey, H. M., Hughes, G. J., Jo, J., Joyce, L. A., Kolev, J. N., Liang, J., Maloney, K. M., Mann, B. F., Marshall, N. M., & McLaughlin, M. (2019). Design of an in vitro biocatalytic cascade for the manufacture of islatravir. Science366(6470), 1255–1259. https://doi.org/10.1126/science.aay8484
  • Mennen, S. M., Alhambra, C., Allen, C. L., Barberis, M., Berritt, S., Brandt, T. A., Campbell, A. D., Castañón, J., Cherney, A. H., Christensen, M., Damon, D. B., Eugenio de Diego, J., García-Cerrada, S., García-Losada, P., Haro, R., Janey, J., Leitch, D. C., Li, L., Liu, F., Lobben, P. C., MacMillan, D. W. C., Magano, J., McInturff, E., Monfette, S., Post, R. J., Schultz, D., Sitter, B., Stevens, J. M., Strambeanu, I. I., Twilton, J., Wang, K., & Zajac, M. A. (2019). The Evolution of High-Throughput Experimentation in Pharmaceutical Development and Perspectives on the Future. Organic Process Research & Development23(6), 1213–1242. https://doi.org/10.1021/acs.oprd.9b00140
  • Carter, H. L., Connor, A. W., Hart, R., McCabe, J., McIntyre, A. C., McMillan, A. E., Monks, N. R., Mullen, A. K., Ronson, T. O., Steven, A., Tomasi, S., & Yates, S. D. (2019). Rapid route design of AZD7594. Reaction Chemistry & Engineering4(9), 1658–1673. https://doi.org/10.1039/c9re00118b
  • Zawatzky, K., Grosser, S., & Welch, C. J. (2017). Facile kinetic profiling of chemical reactions using MISER chromatographic analysis. Tetrahedron73(33), 5048–5053. https://doi.org/10.1016/j.tet.2017.05.048
  • Gurung, S. R., Mitchell, C., Huang, J., Jonas, M., Strawser, J. D., Daia, E., Hardy, A., O’Brien, E., Hicks, F., & Papageorgiou, C. D. (2016). Development and Scale-up of an Efficient Miyaura Borylation Process Using Tetrahydroxydiboron. Organic Process Research & Development21(1), 65–74. https://doi.org/10.1021/acs.oprd.6b00345
  • Rougeot, C., Situ, H., Cao, B. H., Vlachos, V., & Hein, J. E. (2017). Automated reaction progress monitoring of heterogeneous reactions: crystallization-induced stereoselectivity in amine-catalyzed aldol reactions. Reaction Chemistry & Engineering2(2), 226–231. https://doi.org/10.1039/c6re00211k
  • Duan, S., Place, D., Perfect, H. H., Ide, N. D., Maloney, M., Sutherland, K., Price Wiglesworth, K. E., Wang, K., Olivier, M., Kong, F., Leeman, K., Blunt, J., Draper, J., McAuliffe, M., O’Sullivan, M., & Lynch, D. (2016). Palbociclib Commercial Manufacturing Process Development. Part I: Control of Regioselectivity in a Grignard-Mediated SNAr Coupling. Organic Process Research & Development, 20(7), 1191–1202. https://doi.org/10.1021/acs.oprd.6b00070
  • Malig, T. C., Koenig, J. D. B., Situ, H., Chehal, N. K., Hultin, P. G., & Hein, J. E. (2017). Real-time HPLC-MS reaction progress monitoring using an automated analytical platform. Reaction Chemistry & Engineering, 2(3), 309–314. https://doi.org/10.1039/c7re00026j
  • Nykaza, T. V., Ramirez, A., Harrison, T. S., Luzung, M. R., & Radosevich, A. T. (2018). Biphilic Organophosphorus-Catalyzed Intramolecular Csp2–H Amination: Evidence for a Nitrenoid in Catalytic Cadogan Cyclizations. Journal of the American Chemical Society, 140(8), 3103–3113. https://doi.org/10.1021/jacs.7b13803
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