Determination of the Nicotine Content in E-Liquids
A non-aqueous acid-base titration with potentiometric indication
The application describes a method to determine the nicotine content in E-liquids by a non-aqueous acid-base titration with potentiometric indication.
Electronic cigarettes are handheld devices that simulate the feeling of smoking. The so-called E-liquid is vaporized by an electronically heated coil and the vapors are inhaled by the user. The liquid usually consists of propylene glycol, glycerol, flavors and nicotine.
Nicotine is a basic alkaloid that is naturally present in the tobacco plant. It is a psychoactive substance with both stimulant and relaxant effects and therefore an important component of E-liquids. Commercially available E-liquids have nicotine concentrations from 3 to 18 mg/mL.
HClO4 + CH3COOH ⇌ CH3COOH2+ + ClO4- (titrant)
CH3COOH2+ + nicotine ⇌ CH3COOH + nicotineH+
The Application Includes:
- Sample Preparation and Procedures
- Instruments and Accessories
- Method in Detail
- Results and Remarks
And method files ( .lmt and .xml) for direct import and implementation on the instrument.
Nicotine Content in E-Liquids by Potentiometric Titration