Flow Chemistry in Industry-Related Publications
Below is a selection of continuous flow chemistry publications.
Kobayashi, Shū. "Flow “fine” synthesis: high yielding and selective organic synthesis by flow methods." Chemistry–An Asian Journal (2015).
Published by the Synthetic Organic Chemistry Laboratory at the University of Tokyo, this paper focuses the flow "fine" synthesis concept. The advantages of continuous flow methods over batch methods as well as the challenges presented by flow methods are described.
Sans, Victor, and Leroy Cronin. "Towards dial-a-molecule by integrating continuous flow, analytics and self-optimisation." Chemical Society Reviews 45.8 (2016): 2032-2043.
This paper focuses on the use and benefits of continuous flow platforms for synthetic chemistry in both industry and academic research, which highlighting significant contributions in this area.
Mallia, Carl J., and Ian R. Baxendale. "The use of gases in flow synthesis." Organic Process Research & Development 20.2 (2015): 327-360.
Published by the Department of Chemistry at the University of Durham, this paper describes the benefits of using flow chemistry for improved safety and increased efficiency in research. An overview of approaches to introduces gases into flow reactors along with different gaseous reactions already transferred into flow are discussed.
Ley, Steven V., et al. "Organic synthesis: march of the machines." Angewandte Chemie International Edition 54.11 (2015): 3449-3464.
Published by the Ley Research Group at the University of Cambridge Department of Chemistry, this paper describes how organic synthesis methods are changing and how these are helping to address challenges chemists face in research labs.
Baxendale, Ian R. "A short multistep flow synthesis of a potential spirocyclic fragrance component." Chemical Engineering & Technology 38.10 (2015): 1713-1716.
This paper describes how researchers are leveraging flow chemistry to aid in their synthesis challenges, which is making scale-up easier and safer.
Hafner, Andreas, and Steven V. Ley. "Generation of reactive ketenes under flow conditions through zincmediated dehalogenation." Synlett 26.11 (2015): 1470-1474.
This paper describes the generation of highly reactive monoalkyl and phenyl ketenes by using dehalogenation under flow conditions.
Puglisi, Alessandra, et al. "Organocatalysis chemistry in flow." Current Organocatalysis 2.2 (2015): 79- 101.
Recently, organocatalysis has become effective for performing stereoselective reactions in continuo. Stereoselective catalytic flow processes could be used in manufacturing of APIs and chiral intermediates. The paper discusses recent examples of continuous flow processes using organic molecules as catalysts. The paper highlights the potential of combining steroselective processes with solid-supported catalysis in catalytic reactors as well as with photoredox catalysis.
Mueller, Simon TR, et al. "Safe handling of diazo reagents through inline analytics and flow chemistry." Chimica Oggi-Chemistry Today 33 (2015): 5.
Through the use of flow chemistry in multistep processes, dangerous but useful diazo reagents can be accessed for large scale applications. The generation, isolation and use of diazo compounds can be performed continuously, so no large quantities of highly energetic material are accumulated.
Hu, Te, Ian R. Baxendale, and Marcus Baumann. "Exploring flow procedures for diazonium formation." Molecules 21.7 (2016): 918.
This paper describes how to use flow chemistry to for increased safety and continuous manufacturing to determine optimum condititions for the formation of diazonium compounds.
Atodiresei, Iuliana, Carlos Vila, and Magnus Rueping. "Asymmetric organocatalysis in continuous flow: Opportunities for impacting industrial catalysis." ACS Catalysis 5.3 (2015): 1972-1985.
This paper highlights advantages of organocatalytic transformations performed using continuous flow chemistry and which reactions have been successful. Batch and flow applications are compared.
Müller, Simon TR, et al. "Rapid generation and safe use of carbenes enabled by a novel flow protocol with in-line IR spectroscopy." Chemistry–A European Journal 21.19 (2015): 7016-7020.
This paper describes a new continuous process for formation and use of donor/acceptor-substituted carbenes. The safety profile of diazo group transfer on methyl phenylacetate was determined including kinetic studies in batch and flow.