White Paper

Metal Catalyzed Transformations Using In Situ Spectroscopy

White Paper

Organic Chemistry Advances With Chemical Reaction Monitoring

The white paper -  Metal Catalyzed Transformations Using In Situ Spectroscopy - reviews recent advances in organic chemistry, including how:

  • In situ spectroscopy provides valuable, complementary information that enables researchers to determine the mechanism and pathway of a number of different types of chemical reactions
  • Information collected using in situ spectroscopy is of a complementary nature to other structural data - such as nuclear magnetic resonance (NMR) spectroscopy
  • Combining in situ spectroscopy data and kinetics software provides a powerful methodology to study the kinetics of a chemical reaction using fewer experiments than more traditional approaches

Today pharmaceutical and fine chemical companies face major challenges posed by globalization, regulations and shortened product lifecycle. The research and development of optimized chemical synthesis is key to ensure a robust and economic process that can be scaled-up.

Researchers are required to accurately determine the start and endpoints of reactions as well as fully understand, characterize and optimize chemical reactions. This, combined with the need to complete larger numbers of investigations, with less resource and in shorter times, is leading researchers to look for more innovative ways to gain this information.

In situ spectroscopy, when used either on its own or in conjunction with other techniques, is capable of providing important clues that lead researchers to understand the kinetics, pathway and mechanisms of chemical reactions.