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Domov AutoChem Analizatorji velikosti delcev ParticleTrack with FBRM Technology

ParticleTrack with FBRM Technology

Real-Time Particle Size and Count Analysis

ParticleTrack™ with FBRM® (Focused Beam Reflectance Measurement) technology is inserted directly into processes to measure particle count and size in real time at full process concentrations. Scientists can continuously monitor droplets, particles, and particle structure, as experimental conditions vary, providing the confirmation required to deliver consistent particles with the required attributes. The probe-based ParticleTrack instrument utilizes FBRM technology, the industry standard for in-situ process measurements.

Measure and Count Particles In-Situ and in Real Time

ParticleTrack G400

ParticleTrack G400

For Laboratory Environments

Track changing particle size and count in real time at full process concentrations, providing scientists with the evidence required to deliver consistent particles.

particletrack fbrm g600 instrument on white background

ParticleTrack G600/G600 Ex

For Pilot Plants and Production

Install in reactors or pipelines using standard flanges, dip pipes, and ball valves across a wide range of temperatures and pressures. Rated to ATEX and Class I, Div 1 standards.

Focused Beam Reflectance Measurement (FBRM)

ParticleTrack particle size analyzers utilize FBRM, the industry-standard measurement technique used for in-process particle measurement. The precise and sensitive chord length distributions (CLD) are highly responsive to changes in size, shape, or count. Real-time analysis allows researchers to observe how process changes impact particles directly.

Accelerate Particle Process Development

Other particle characterization techniques rely on offline sample collection and manual preparation which introduces time delays and sampling errors, complicating process development.

By inserting a ParticleTrack probe directly into a reactor or process stream, scientists can continuously monitor particle size and count trends in-situ, providing immediate process understanding. Equipped with this knowledge, scientists can confidently improve processes faster.

accelerate process development

Link Process to Particle Performance

Product quality and downstream processing performance are directly impacted by the parameters used to produce crystals, particles, and droplets. ParticleTrack allows scientists to directly link these parameters to particle mechanisms. By understanding the impact of process parameters have on particle mechanisms, such as nucleation, growth, agglomeration, breakage, and shape change, scientists can avoid process risks and produce better particles, faster. 

By characterizing the effect of process parameters during development, scale-up, and production, scientists deliver high-quality particle products to the market faster and at a lower total cost using evidence-based methods. 

link process to particle performance

Data Analysis Made Easy

iC FBRM™ software enables seamless integration for process development in the lab, plant, and production scales. iC FBRM reduces data analysis time with distribution comparisons to highlight regions of change and data relationships with linked views. Data summary reports of the experiment are generated with a single click. 

data analysis made easy

Produce Fit-For-Purpose Particles at Any Scale

Optimal process parameters are unique to every process involving crystals, particles, or droplets. With ParticleTrack, scientists, researchers, and engineers can effectively characterize particle systems and design the process parameters to consistently deliver particles with the desired size and count at scale.

The ATEX-certified ParticleTrack G600EX allows for direct real-time comparison with lab results, providing scientists and engineers with the ability to monitor and optimize production processes to consistently deliver high-quality products.

fbrm lab to plant
particletrack fbrm g400 system

ParticleTrack G400

For the R&D Lab
  • Compact design for portability and minimal laboratory footprint
  • Interchangeable probes for use across a wide range of laboratory scales (10 mL to 2 L)
  • Seamless integration with OptiMax and EasyMax synthesis workstations for optimized experimental setup
  • iC FBRM software for fast and intuitive particle data analysis

particletrack fbrm g600

ParticleTrack G600/G600 Ex

For Pilot and Production

  • Flexible mounting options including common flanges, dip pipes, and ball valves enable the installation of probes in reactors or pipelines
  • Operates over a wide temperature and pressure range
  • Safe to use in hazardous locations, including ATEX and Class I, Division 1 environments

particle engineeriong workstation

The Ultimate Particle Engineering Workstation

ParticleTrack and iC FBRM™ software seamlessly integrate into EasyMax and iControl™ for easy experimental design. When experiments combine particle size analysis with Raman spectroscopy and FTIR spectroscopy, scientists can confidently overlay data in the iC Software to get answers and accelerate the development of particle systems.

  • EasyViewer – A plug-and-play inline microscope provides high-resolution images immediate process understanding and particle measurements based on intuitive image analysis
  • ReactRaman – A compact, high-performance Raman spectrometer provides critical insight for even the most challenging reactions, including crystallization processes, polymorphism detection, and multiphasic reactions
  • ReactIR – A user-friendly in-situ FTIR spectrometer enables scientists to measure reaction trends and profiles in real time, providing highly specific information about supersaturation, reaction kinetics, mechanisms, and pathways

Understand precisely how process parameters impact concentration, size, shape, and structure to make better decisions, eliminate process risks and solve problems — faster.

Crystallization Process Design

Crystallization Process Design

New Technologies for Crystallization Process Design

PAT for Emulsions

PAT For Emulsion Characterization

Utilizing Process Analytical Technology (PAT) to Optimize Emulsions

Crystallization Process pdf

Effective Crystallization Process Development

A Guide to Crystallization and Precipitation

crystal size distribution ppt

Advanced Strategies to Control Crystal Size Distribution

Advanced Techniques to Optimize Crystal Size Distribution During Process Development and Manufacturing

Crystallization in Process Chemistry

Crystallization in Process Chemistry

Applying Simple PAT Tools

What is the difference between the ParticleTrack G400 and G600 models?

In short, the G400 and G600 models were designed with different process environments in mind. The ParticleTrack G400 is best suited for laboratory applications while the G600 model is best for pilot plant and plant operations. 

Unsure of which model is best for your application? Contact us today!

What is FBRM? How does it work?

FBRM™ (Focused Beam Reflectance Measurement) is a measurement technique used for in-process particle measurement. The precise and sensitive chord length distributions (CLD) are highly responsive to changes in size, shape, or count. 

The probe is placed at an angle straight into process streams to allow particles to flow freely across the probe window where the measurement takes place. Through a system of optics, a laser beam is sent down the probe tube and narrowly focused on the sapphire window. The optics rotate at a constant rate (usually 2 m/s), which causes the beam spot to sweep through particles quickly as they pass by the window.

Individual particles or particle structures will backscatter the laser light to the detector when the concentrated beam travels through the particle system. These separate backscattered light pulses are identified, counted, and the distance across each particle is determined by multiplying the duration of each pulse by the scan speed.

The chord length, a crucial indicator of the particle's relationship to particle size, is used to determine this distance. Thousands of particles are typically counted and measured per second, enabling the real-time reporting of an accurate and very sensitive chord length distribution.

The chord length distribution charts the evolution of particle size and counts from the start to the finish of a procedure. It is possible to chart the evolution of statistics from each chord length distribution, such as counts in the fine and coarse size classes.

ParticleTrack FBRM in Peer-Reviewed Publications

  1. McTague, H., & Rasmuson, K. C. (2021). Nucleation in the Theophylline/Glutaric Acid Cocrystal System. Crystal Growth & Design, 21(7), 3967–3980. doi.org/10.1021/acs.cgd.1c00296
  2. Sirota, E., Kwok, T., Varsolona, R. J., Whittaker, A., Andreani, T., Quirie, S., Margelefsky, E., & Lamberto, D. J. (2021). Crystallization Process Development for the Final Step of the Biocatalytic Synthesis of Islatravir: Comprehensive Crystal Engineering for a Low-Dose Drug. Organic Process Research & Development, 25(2), 308–317. doi.org/10.1021/acs.oprd.0c00520
  3. Smith, J. P., Obligacion, J. V., Dance, Z. E. X., Lomont, J. P., Ralbovsky, N. M., Bu, X., & Mann, B. F. (2021). Investigation of Lithium Acetyl Phosphate Synthesis Using Process Analytical Technology. Organic Process Research & Development, 25(6), 1402–1413. doi.org/10.1021/acs.oprd.1c00091
  4. Kavanagh, O., Hogan, F., Murphy, C., Croker, D., & Walker, G. (2020). Formulating a Stable Mannitol Infusion while Maintaining Hyperosmolarity. Pharmaceutics, 12(2), 187. doi.org/10.3390/pharmaceutics12020187
  5. Kutluay, S., Ceyhan, A. A., ŞAhin, M., & İZgi, M. S. (2020). Utilization of In Situ FBRM and PVM Probes to Analyze the Influences of Monopropylene Glycol and Oleic Acid as Novel Additives on the Properties of Boric Acid Crystals. Industrial & Engineering Chemistry Research, 59(19), 9198–9206. doi.org/10.1021/acs.iecr.0c00551
  6. Tanaka, K., & Takiyama, H. (2019). Effect of Oiling-Out during Crystallization on Purification of an Intermediate Compound. Organic Process Research & Development, 23(9), 2001–2008. doi.org/10.1021/acs.oprd.9b00256
  7. Yang, H., Kim, J., & Kim, K. (2019). Study on the Crystallization Rates of β‐ and ϵ‐form HNIW in in‐situ Raman Spectroscopy and FBRM. Propellants, Explosives, Pyrotechnics, 45(3), 422– 430. doi.org/10.1002/prep.201900194
  8. Maloney, M. T., Jones, B. P., Olivier, M. A., Magano, J., Wang, K., Ide, N. D., Palm, A. S., Bill, D. R., Leeman, K. R., Sutherland, K., Draper, J., Daly, A. M., Keane, J., Lynch, D., O’Brien, M., & Tuohy, J. (2016). Palbociclib Commercial Manufacturing Process Development. Part II: Regioselective Heck Coupling with Polymorph Control for Processability. Organic Process Research & Development, 20(7), 1203–1216. doi.org/10.1021/acs.oprd.6b00069
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